2020
DOI: 10.1177/0300060520913423
|View full text |Cite
|
Sign up to set email alerts
|

Dexmedetomidine as an adjuvant for single spinal anesthesia in patients undergoing cesarean section: a system review and meta-analysis

Abstract: Objective Previous studies reported the effect of dexmedetomidine on intrathecal anesthesia. In this review, we explored the impact of dexmedetomidine as an adjunct for lumbar anesthesia in patients undergoing cesarean section. Methods Two authors searched eligible random controlled trials in electronic databases, including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, the Chinese BioMedical database, Chinese Scientific Journal Database, and the Wanfang database. Re… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
12
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 17 publications
(14 citation statements)
references
References 44 publications
(76 reference statements)
1
12
0
Order By: Relevance
“…DEX has been reported to be safe to use intrathecally. Previously published meta-analysis and reviews have shown that intrathecal infusions of DEX can shorten the onset time of spinal anesthesic as well as enhance and prolong their sensory and motor effects, and increasing the time to the need for pain rescue after spinal anesthesia [ 11 , 12 ]. Khosravi et al demonstrated that intrathecal DEX produced better outcomes in terms of analgesia, sedation, and hemodynamic parameters compared to intravenous DEX [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…DEX has been reported to be safe to use intrathecally. Previously published meta-analysis and reviews have shown that intrathecal infusions of DEX can shorten the onset time of spinal anesthesic as well as enhance and prolong their sensory and motor effects, and increasing the time to the need for pain rescue after spinal anesthesia [ 11 , 12 ]. Khosravi et al demonstrated that intrathecal DEX produced better outcomes in terms of analgesia, sedation, and hemodynamic parameters compared to intravenous DEX [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…The use of intrathecal dexmedetomidine during cesarean section can shorten the onset time of spinal anesthesia and enhance the effect of local anesthetic. It has no significant impact on neonates and there were no other adverse events [ 7 ]. Although postural regulation and fluid expansion can alleviate hypotension after spinal anesthesia, the incidence of maternal hypotension is still high.…”
Section: Discussionmentioning
confidence: 99%
“…The primary outcome was defined as the additional dose of NE and the secondary outcome was defined as other indicators of puerperaes and neonates, including the incidence of maternal hypotension. General condition of parturient: age, gestational age, body mass index, volume of bleeding and fluid replacement; intervention dose of norepinephrine and atropine; incidence of maternal hypotension and adverse reactions (reactive hypertension, chest tightness, nausea, shivering, oxytocin reaction); neonatal 1-minute and 5-minute Apgar score [ 7 ] and umbilical cord drive, venous blood gas value. Apgar score: 0–3 is severe asphyxia, 4–7 is mild asphyxia, and 8–10 is no asphyxia.…”
Section: Methodsmentioning
confidence: 99%
“…Like clonidine, when administered as a neuraxial adjuvant it reduces the required local anesthetic dose and prolongs and potentiates post-operative analgesia [ 161 ]. The sensory and motor block doubles when intrathecal dexmedetomidine is used [ 162 ]. Intravenously administered dexmedetomidine also prolongs the anesthetic effect of intrathecal local anesthetics [ 155 , 156 , 163 ].…”
Section: Neuraxial Drugs In Clinical Usementioning
confidence: 99%