Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy?

Abstract

Sun (2020) Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid-polymer hybrid nanoparticles, which performed better for local anesthetic therapy?,

Combination Therapy of Metastatic Castration-Recurrent Prostate Cancer: Hyaluronic Acid Decorated, Cabazitaxel-Prodrug and Orlistat Co-Loaded Nano-System

“… 48 Yan et al developed a negatively charged, docetaxel and curcumin co-loaded nanoparticles (−38 mV) for prostate cancer therapy. 49 They argued that the negative surface charge of NPs can reduce the systematic toxicity and were important for efficient cancer therapy. Lu and colleagues also concluded that the negatively charged HA added negative charge to the NPs and obtained a more negatively charged NPs for the delivery to lung cancer cells.…”

Acute myocardial infarction therapy: in vitro and in vivo evaluation of atrial natriuretic peptide and triphenylphosphonium dual ligands modified, baicalin-loaded nanoparticulate system

“…Lipid materials were reported as biocompatible and less toxic, which were introduced to reduce the cytotoxicity of the drug delivery systems (Li et al., 2020 ). Zheng et al.…”

Advances in the use of local anesthetic extended-release systems in pain management

“…Li M et al. prepared transactivated transcriptional activator-modified, levobupivacaine and dexmedetomidine codelivered LPN, which showed significant improvements in skin penetration, analgesic duration, and analgesic efficacy (Li M et al., 2020 ). In another experiment, ropivacaine lipid-polymer hybrid nanoparticles (RPV-LPNs), which were formed by wrapping ropivacaine (RPV) with poly-ε-caprolactone (PCL) as the polymer core and poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the lipid shell were significantly more effective than free ropivacaine anesthesia, with a rapid response within minutes, a long duration, and high penetration (Li A et al., 2019 ).…”