Dexamethazone Prophylaxis before Near Total Thyroidectomy to Reduce Vocal Dysfunction: A Randomized Clinical Trial

The Use of Dexamethasone in Prevention of Symptomatic Hypocalcemia after Total Thyroidectomy

“…Regarding alteration of voice, neither our investigation nor that of Marcello et al found any statistically significant results (4). Nonetheless, following thyroidectomy, Abdel Latif et al and Worni et al results demonstrated an improvement in postoperative voice quality function (13,15). In Shirzad N. study, 68 patients were included and found that the use of steroids pre-operatively was statistically significant in lowering the vis score in day 1, yet no statistical significance after a week (16).…”

Use of Prophylactic Steroids to Prevent Hypocalcemia and Voice Dysfunction in Patients Undergoing Thyroidectomy

“…That study further found that improvement was more evident within 16 hours after surgery. Abdel Latif et al also found that a single dose of dexamethasone during the preoperative period effectively prevented temporary, recurrent laryngeal nerve palsy. Another recently published prospective nonrandomized study compared the outcome of dexamethasone use in 2 groups during intraoperative neural monitoring.…”

“…23,24 There has been minimal discussion of the effect of dexamethasone on post-operative transient hypocalcemia. Results of 2 different RCTs 13,25 showed that dexamethasone, when given in a single preoperative dose, reduces the chance of hypocalcemia. The effectiveness of a single preoperative dexamethasone dose was evident in our study.…”