Dexamethasone Suppression Test May Predict More Severe/Violent Suicidal Behavior

Alacreu‐Crespo, Adrián; Olié, Émilie; Guillaume, Sébastien; Girod, Chloé; Cazals, A.; Chaudieu, Isabelle; Courtet, Philippe

doi:10.3389/fpsyt.2020.00097

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…Au niveau biologique, ces phénomènes ont été associés à une augmentation de l'activité de l'axe hypothalamo-hypophyso-surrénalien [26] et du niveau d'inflammation périphérique [27]. Ces deux caractéristiques sont positivement associées au risque suicidaire [28][29][30] et induisent des modifications structurelles cérébrales pouvant affecter la régulation des émotions et les cognitions sociales [31].…”

Section: Distanciation Déconnexion Sociale Et Suicideunclassified

Épidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives

et al. 2020

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Section: Distanciation Déconnexion Sociale Et Suicideunclassified

Épidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives

et al. 2020

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“…Moreover, decreased cortisol secretion may precede a suicidal act [ 88 ]. The dexamethasone suppression profile may help to predict the most lethal suicidal acts during a 2-year follow-up [ 89 ]. Finally, patients at risk of suicide may show higher susceptibility to HPA dysregulation following SARS-CoV-2 infection because the virus targets the ACE-2 and the ACE/ACE-2 balance that is associated with HPA dysregulation in depressed individuals [ 40 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

How Does COVID-19 Affect the Neurobiology of Suicide?

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Olié

et al. 2021

Curr Psychiatry Rep

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Purpose of Review The aim of this review was to analyze COVID-19 effect on the biological features of suicidal vulnerability and its interaction with suicide-related biological pathways. We carried out a narrative review of international publications on the interactions of COVID-19 with the biological bases of suicide. Recent Findings We hypothesize that SARS-CoV-2 interacts with multiple biological processes that underlie suicidal behavior, such as the renin-angiotensin system, nicotinic receptors, and central and systemic inflammation. Social distancing measures may also worsen subjective or objective social disconnection, thus increasing the risk of suicide. Interestingly, the drugs used to prevent suicide could be promising options to counteract brain damage caused by this coronavirus. Summary SARS-CoV-2 interacts with multiple biological pathways involved in suicide and opens a new window for understanding the suicidal process. The development of suicide prevention treatments in the context of a pandemic may benefit from knowledge on these interactions.

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“…The failure of HPA axis feedback is a marker of serious mental disorders such as attempted suicide in individuals with major depression. 4 LEO was able to lower cortisol levels in K4 compared to other groups.…”

Section: Discussionmentioning

confidence: 70%

“…Failure to suppress plasma cortisol concentrations after dexamethasone administration suggests impaired HPA axis feedback regulation. 4 This principle is used to create a depression model rat using corticosteroid injection.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of lavender essential oils on depression and multi-organ stress

et al. 2022

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Introduction: Lavender essential oils (LEO) have been known to have relaxing effects, improve mood, and treat anxiety, but the effect on multiple organ stress concurrently is unknown. This multiorgan stress is related to depression can be caused by chronic psychological stress due to excessive cortisol levels and can lead to organ damage. This study analyzed LEO in preventing depression and multiorgan failure using intraperitoneal injection of corticosteroids in animal-model. Methods: Rats (Rattus norvegicus) Wistar strain, male, aged 7-8 weeks were involved in this study. Depression in animal-model is defined by immobilization using tail suspension test and anhedonia using sucrose preference test. LEO 5% was diluted in virgin coconut oils as vehicle. Serum cortisol was analyzed using enzyme-linked immunosorbent assay (ELISA). Organs were extracted and processed using hematoxylin eosin staining. Results: The results of this study indicate that LEO was able to prevent damage to the glial cells, myocardiac cells, and gastrointestinal mast cells infiltration, but not to the hepatocytes and renal cells damage. LEO also induced behavioral activation as improvement of depression, but anhedonia was still remained. Conclusion: The effect of LEO is to prevent the increase in blood cortisol levels, thus reduce the reactivity of depressed individuals to stress, although the individual still has anhedonia as a residual symptoms

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Dexamethasone Suppression Test May Predict More Severe/Violent Suicidal Behavior

Abstract: These findings might help to characterize the biological features of nearest suicide phenotypes.

Cited by 13 publications

References 48 publications

Épidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives

Épidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives

How Does COVID-19 Affect the Neurobiology of Suicide?

Protective effect of lavender essential oils on depression and multi-organ stress

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