Dexamethasone's Effect in the Retrocochlear Auditory Centers of a Noise‐Induced Hearing Loss Mouse Model

Chen, Leon; Dean, Clare; Gandolfi, Michele M.; Nahm, Edmund A.; Mattiace, Linda A.; Kim, Ana H.

doi:10.1177/0194599814545771

Cited by 12 publications

(8 citation statements)

References 26 publications

(80 reference statements)

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“…44 The dexamethasone could attenuate noise-induced HL by reducing outer hair cell death and other glucocorticoid receptor-mediated effects in the cochlea. 45 Our analysis has several limitations. First, because of the limited data for participant characteristics and study designs, meta-regression analysis was not possible.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Ding

2020

Ann Pharmacother

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Background: The best way to administer steroids for sudden sensorineural hearing loss (SSHL) is still unclear. The present study was aimed at estimating the efficacy of steroids by intratympanic, systemic, and combined therapy (CT) routes. Methods: A systematic literature search was performed from 1950 to October 2019 for randomized controlled trials comparing the use of intratympanic, systemic, and combined steroid therapy for SSHL. The outcomes of recovery rate and pure tone average (PTA) improvement were assessed by random-effects and fixed-effects meta-analysis. Results: A total of 20 articles identified from 7 countries were eligible for analysis. Although no significant difference in recovery rate was observed between intratympanic steroid therapy (IST) and systemic steroid therapy (SST), IST did demonstrate better hearing improvement, as evidenced by a higher PTA than SST. Compared with SST, CT comprising IST and SST had significant recovery rate improvement. Patients treated with CT had a significantly higher PTA than those treated with SST. Through subgroup analysis based on the equivalent dose of prednisone, it was shown that CT led to a significantly higher PTA than SST only in the high-dose CT versus high-dose SST groups and moderate-dose CT versus high-dose SST groups. Conclusion: Moderate and high dose of CT could accelerate hearing improvement in SSHL.

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Section: Discussionmentioning

confidence: 99%

“…44 The dexamethasone could attenuate noise-induced HL by reducing outer hair cell death and other glucocorticoid receptor–mediated effects in the cochlea. 45…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Ding

2020

Ann Pharmacother

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“…IT DEX administration causes a dose-dependent preservation of retrocochlear auditory neurons in an NIHL mouse model. 22 Glucocorticoids can be used as a primary initial treatment or as a salvage therapy for SSNHL, but the clinical therapeutic outcomes of IT steroid treatments are associated with the application timing, dosage, and administration protocol. 23,24 Regardless, the key factor is delivery of a sufficient DEX concentration to the perilymph.…”

Section: Discussionmentioning

confidence: 99%

“…Heinrich et al showed that a pretreatment with DEX could prevent noise‐induced glucocorticoid receptor degradation in the lateral wall of the cochlea, implying that DEX plays a role in receptor protein turnover and restoration. However, animal studies using IT DEX treatment for NIHL have shown inconsistent results, possibly reflecting differences in the degree of acoustic trauma sustained in each animal model, the applied dose, and the duration of the DEX administration.…”

Section: Discussionmentioning

confidence: 99%

Middle‐ear dexamethasone delivery via ultrasound microbubbles attenuates noise‐induced hearing loss

et al. 2018

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Objectives/Hypothesis In this study, we expanded our previous investigation by testing the efficiency of trans–round window membrane dexamethasone (DEX) delivery mediated by ultrasound (US)‐aided microbubbles (MBs) and its preventive effects regarding noise exposure in animal models. Study Design Live animal model. Methods Forty‐two pigmented male guinea pigs were divided into the following three groups: an US‐MBs (USM) group, in which the tympanic bulla was filled with DEX and MBs and exposed to US; a round window soaking (RWS) group, without the US irradiation; and a control group. The above‐mentioned manipulations were performed 2 hours prior to white noise exposure. The cochlear damage, including auditory threshold shifts, hair cell loss, and expression of cochlear HMGB1, was evaluated. Results The enhanced DEX delivery efficiency of the USM group was approximately 2.4× to 11.2× greater than that of the RWS group. After the noise exposure, the RWS group showed significant cochlear protection compared with the control group, and more significant and dominant protective effects were demonstrated in the USM group. Conclusions The application of US‐MBs provides a safe and more effective approach than spontaneous diffusion, which is commonly used in clinical practice; thus, this technique holds potential for future inner‐ear drug delivery. Level of Evidence NALaryngoscope, 129:1907–1914, 2019

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“…DXM'nin işitme kayıplarında koruyucu ve tedavi edici etkileri daha önceki çalışmalarda gösterilmiştir. 12,13 Bunun yanı sıra farklı maddelerin; N-asetilsistein, koenzim Q, E vitamini, C vitamini, A vitamini, magnezyum, idebenon, çörek otu yağı gibi antioksidanların akustik travma üzerine etkileri ile ilgili farklı çalışmalar mevcuttur. [14][15][16][17] Üzümün (Vitis vinifera) tıbbi ve besinsel değeri binlerce yıldır bilinmektedir.…”

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Effect of Grape Seed Oil and Dexamethasone on Acoustic Trauma in Rats

Görüş¹,

Erbek²,

Çulhaoğlu³

et al. 2018

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Dexamethasone's Effect in the Retrocochlear Auditory Centers of a Noise‐Induced Hearing Loss Mouse Model

Abstract: Our NIHL mouse model demonstrated dose-dependent Dex pretreatment otoprotection against NIHL with preservation of retrocochlear auditory neurons.

Cited by 12 publications

References 26 publications

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Middle‐ear dexamethasone delivery via ultrasound microbubbles attenuates noise‐induced hearing loss

Effect of Grape Seed Oil and Dexamethasone on Acoustic Trauma in Rats

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