Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery

García-Couce, Jomarien; Bada-Rivero, Nancy; Hernández, Orestes Darío López; Nogueira, Antonio; Caracciolo, Pablo C.; Abraham, Gustavo Abel; Hernández, José A. Ramón; Péniche, Carlos

doi:10.1155/2019/4204375

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…A controlled release of the drug Dexamethasone from CS was observed once the coating layer of the pH-dependent polymer complex started to dissolve at a higher pH (6.8). It was concluded that the CS nanoparticles coated with PAA-PVP complexes can be used for effective controlled delivery of the drug directly to the colon [44].…”

Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…The nanocomposites of chitosan can hold and protect anticancer drugs quite efficiently and effectively. One study showed the development of chitosan nanoparticles loaded with dexamethasone, followed by coating with a pH-dependent interpolymer complex based on poly(acrylic acid)/ poly(vinyl pyrrolidone) polyblends complexes that were very effective when it comes to directed drug delivery to the colon as these coated particles have significantly large protection in simulated gastric fluid [15]. Chitosan-magnetic nanoparticle (CS-MNP)-based carrier system is another carrier system that has been studied quite extensively for cancer treatments in the last few years.…”

Section: Chitosan-based Nanocomposites In Cancer Treatmentsmentioning

confidence: 99%

Chitosan-Based Drug Conjugated Nanocomposites: Advances and Innovation in Cancer Therapy

Kumar

2023

Regen. Eng. Transl. Med.

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Purpose Cancer is one of the most lethal diseases globally. About ten million people die from cancer every year. Chemotherapy, hormone therapy, immunotherapy, targeted therapy, or radiation therapy are currently the most popular cancer treatments. The fact that these methods frequently result in significant system toxicity and even the recurrence of the sickness means that while they have achieved some encouraging results, they have not been entirely successful. Methods We searched the literature using PubMed, Scopus, and Google Scholar with the keywords "Chitosan; nanocomposites; cancer; targeted drug delivery; and promising delivery tool." The literature search included only articles written in the English language. Results Biopolymer-based cutting-edge drug delivery techniques can deliver the drug directly to the tumor site, allowing for more controlled drug distribution, with a higher level of efficacy, and have caught the attention of scientists studying cancer drug delivery. Mannan, dextran, chitosan, pectin, amylose, hyaluronic acid, and other carbohydrate biopolymer-based delivery systems offer improved bioavailability and biocompatibility. The nanocomposites of chitosan are potential polymer matrices mixed with anticancer medications to generate nanocomplexes as novel formulations. Conclusions The perspective of the article is to provide a glimpse of chitosan-based nanocomposites used in drug delivery and focused on the role of chitosan-based anticancer drug carrier nanocomposites developed recently as a promising tool in cancer therapy. Lay Summary Biopolymer-based nano-drug delivery systems (DDS) deliver drugs to the tumor site in a targeted and controlled manner that makes the drug operative. Nanocomposites of biopolymers have good bioavailability and chitosan-based DDS is very promising because of the various physical and chemical attributes of chitosan. This article draws a convincing purview of chitosan-based nanocomposites used in drug delivery and focused on the role of chitosan-based anticancer drug carrier nanocomposites developed recently as a promising tool in cancer therapy.

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“…Sabra et al [ 6 ] also proposed chitosan-pectinate nanoparticles for the colon-targeted delivery of curcumin, prepared by the ionic gelation method. In addition, dexamethasone-loaded chitosan microparticles prepared by spray drying presented a potential use as a means of colon-specific drug delivery [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery

Siles-Sánchez

Jaime

Villalva

et al. 2022

Foods

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In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems.

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Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery

Cited by 10 publications

References 44 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Chitosan-Based Drug Conjugated Nanocomposites: Advances and Innovation in Cancer Therapy

Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery

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