“…As reported, PDE4 (cAMP-specific) features prominently in the central nervous system, and among the 11 PDE family members. PDE4B, belonging to PDE4, is crucial in regulating neuroinflammation, and PDE4B inhibitors have neuroprotective effects [42][43][44]. Reportedly, miR-124-3p represses the activity of mTOR signaling by repressing PDE4B expression, and is crucial on neuronal inflammation caused by brain injury [45].…”