Dexamethasone induces different wheel running activity than corticosterone through vasopressin release from the suprachiasmatic nucleus

Isobe, Yoshiaki; Torii, Takako; Kawaguchi, Tatsuro; Nishino, Hitoo

doi:10.1016/j.brainres.2004.09.021

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…: +86 551 2922342; fax: +86 551 5120742. of AVP or AVP mRNA in the SCN [7,8]. While corticosterone and dexamethasone had different effects on circadian locomotor activity, AVP mRNA in the SCN was decreased both by corticosterone and dexamethasone [9]. At the molecular level, glucocorticoid was reported to down-regulate the AVP mRNA transcription at the promoter region in glucocorticoidresponsible elements (GRE) of the AVP gene [10,11].…”

Section: Introductionmentioning

confidence: 97%

Glucocorticoids suppress vasopressin gene expression in human suprachiasmatic nucleus

Liu

Unmehopa

Zhou

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Introductionmentioning

confidence: 97%

Glucocorticoids suppress vasopressin gene expression in human suprachiasmatic nucleus

Liu

Unmehopa

Zhou

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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“…Centrally administered AVP decreased body temperature (Winslow & Insel 1993). The AVP containing neuron is one of the output paths from the SCN (Buijs et al 1993;Kalsbeek et al 1998;Isobe et al 2004b). From the standpoint of thermoregulation, an analysis of the AVP coding mRNA profile is important.…”

Section: Introductionmentioning

confidence: 99%

“…The AVP mRNA decrease at 9 h after maternal deprivation might not directly reflect the thermal effect, but correspond to the time of dusk. AVP and AVP mRNA responses in the SCN to photic and non-photic stimulation are closely related to circadian rhythms (Isobe & Nishino 2004a;Isobe et al 2004b). A future study has been planned to provide evidence that the maternal environmental condition affects the development of the pup circadian rhythm of Per2 mRNA and provide further information on AVP peptide functions.…”

mentioning

confidence: 94%

“…Our data shows that the Per2 and g-enolase mRNA levels might be influenced by the metabolic stage. Moreover, the Per2 level is higher during the light period when the body temperature is low, reflecting circadian oscillation (Isobe & Nishino 2004b). In conclusion, a mild temperature drop increases Per2 mRNA, which indicates that the CCG might be influenced by dam separation.…”

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confidence: 97%

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Thermoregulatory responses in rat pups during the nursing period: effects of separation from the dam on Per2, Bmal1, LDH and Arg-vasopressin mRNAs in the suprachiasmatic nucleus

Isobe

Kawaguchi²,

Tauchi³

2005

Biological Rhythm Research

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Thermoregulatory responses of rat pups with or separated from the dam were examined in relation to clock-controlled genes in the suprachiasmatic nucleus (SCN). During the nursing period, the decreased incidence of maternal contact with the pups was correlated inversely with the rising body temperature of the dam under the dark period. We determined the levels of Per2, Bmal1 and AVP mRNAs using RT-PCR in the SCN of pups after separation from the dam, which induces hypothermia. The Per2 changes were coordinated with the body temperature decrease after separation from the dam. In adult rats, the body temperature drop induced by pentobarbital administration was larger during the light than in the darkness. The alpha-and g-enolase, LDHa and LDHb mRNA, which are coupled with the metabolic state, were measured simultaneously with the clock related gene mRNAs, following hypothermia in pups on postnatal day 6. After dam separation, the Per2 and Bmal1 levels in pups increased after 1 h during the dark period, while AVP decreased after 9 h during the light period. The results indicate that the nursing dam influences Per2, Bmal1 and AVP mRNA transcriptions in the pup SCN through hypothermia (non-photic stimulation) induced by separation from the dam.

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“…Glucocorticoids inhibit AVP expression in the human SCN [36], as well as the rat and human PVN [37,38]. Although these studies did not examine glucocorticoid effects on AVP expression in the rat SCN, glucocorticoids inhibit AVP release both in vitro and in vivo [39]. In contrast, glucocorticoid effects appear to be negligible for VIP mRNA.…”

Section: Discussionmentioning

confidence: 97%

Changes in vasoactive intestinal peptide and arginine vasopressin expression in the suprachiasmatic nucleus of the rat brain following footshock stress

McGivern

2007

Neuroscience Letters

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The neuropeptides, arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are synthesized by neurons of the suprachiasmatic nucleus (SCN) of the hypothalamus and are important regulators of SCN function. Previous studies have demonstrated that acute exposure to stressors can disrupt circadian activity rhythms, suggesting the possibility of stress-related alterations in the expression of these neuropeptides within SCN neurons. In this study, we examined the effect of intermittent footshock stress on AVP mRNA and heterogeneous nuclear RNA (hnRNA) and VIP mRNA expression in neurons of the SCN. Young adult male Sprague/Dawley rats were subjected to 15 seconds of scrambled intermittent footshock (0.50 mA pulses, 1 pulse/second, 300 msec) every 5 minutes for 30 minutes. Animals were sacrificed 75 or 135 min after the onset of stress and brains examined for AVP mRNA and hnRNA, and VIP mRNA using in situ hybridization. Footshock stress increased AVP hnRNA levels at the 75 min timepoint whereas AVP mRNA was elevated at both the 75 and 135 min. timepoints. In contrast, footshock stress decreased the number of cells expressing VIP mRNA in the SCN without changing hybridization level per cell. These data indicate that the disruptive effect of stress on activity rhythms correlate with alterations in the expression of regulatory peptides within the SCN.

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Dexamethasone induces different wheel running activity than corticosterone through vasopressin release from the suprachiasmatic nucleus

Cited by 8 publications

References 29 publications

Glucocorticoids suppress vasopressin gene expression in human suprachiasmatic nucleus

Glucocorticoids suppress vasopressin gene expression in human suprachiasmatic nucleus

Thermoregulatory responses in rat pups during the nursing period: effects of separation from the dam on Per2, Bmal1, LDH and Arg-vasopressin mRNAs in the suprachiasmatic nucleus

Changes in vasoactive intestinal peptide and arginine vasopressin expression in the suprachiasmatic nucleus of the rat brain following footshock stress

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