Dexamethasone-induced perineal irritation in head injury

Klygis, Linas M.

doi:10.1016/0735-6757(92)90230-u

Cited by 17 publications

(4 citation statements)

References 6 publications

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“…This, results were in accordance to the studies published by Baharav et al and Klygis. 35,36 Thus it was inferred through current study findings that coadministration of lignocaine and dexamethasone in combination significantly reduced the pain induced during propofol induced anesthesia, in comparison to…”

Section: Discussionmentioning

confidence: 62%

A comparative study of intravenous lignocaine, dexamethasone and combination of lignocaine-dexamethasone in attenuating propofol induced pain

Kuriakose

Krishnakumar

2022

Int J Res Med Sci

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Background: General anesthesia is preferred during surgeries to reduce the pain stimuli in patients and to increase the precision of surgical procedure. Propofol is amongst the most widely used general anesthetic agent with limitation of induced pain during administration. Current study was conducted to compare the effect of intravenous pre-administration of various drugs in attenuating propofol induced pain. Methods: A comparative observational study was conducted on patients of either sex and aged between 18-60 years. Patients were divided in three groups, who received intravenous lignocaine, dexamethasone and combination of lignocaine-dexamethasone respectively to attenuate propofol induced pain. Different variables like HR, SBP, DBP, MAP, RR SpO2 and any adverse events were monitored in all the patients. Results: The 46.66% and 53.33% patients who received lignocaine and dexamethasone alone perceived propofol induced mild to moderate pain; while only 23.33% patients who received lignocaine and dexamethasone in combination perceived mild propofol induced pain. The propofol induced pain event was persistent in only 2 out of 30 patients after a time lapse of 30 seconds for the group receiving lignocaine and dexamethasone in combination. Whereas, the pain event was present even after time lapse of 30 seconds in 08 and 07 out of 30 patients of groups receiving lignocaine and dexamethasone alone.Conclusions: Pre-administration of lignocaine and dexamethasone in combination attenuated the propofol induced pain more significantly in comparison to single administration of mentioned drugs. No significant adverse events except perianal irritation were observed in some patients who received combination of lignocaine and dexamethasone intravenously.

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Section: Discussionmentioning

confidence: 62%

A comparative study of intravenous lignocaine, dexamethasone and combination of lignocaine-dexamethasone in attenuating propofol induced pain

Kuriakose

Krishnakumar

2022

Int J Res Med Sci

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“…21 Dexamethasone-induced perineal pruritus is commonly observed during induction of anesthesia. 22 Singh et al 23 performed a small prospective study in which 60 patients experienced pruritus in many patients after administration of intravenous dexamethasone sodium phosphate, he also observed perineal itching or excruciating pain in patients receiving dexamethasone is more common in female patients with incidence more than 55%. The findings of present study shows, in lignocaine group 5 (10%) out of the 50 patients had perineal pruritus, whereas 22 (44%) out of the 50 patients had perineal pruritus in placebo Mild perineal pruritus was lower number of patients in lignocaine group when compared with placebo group (3 versus 13; P<0.05).…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Lignocaine in Attenuating Dexamethasone Induced Perineal Pruritus During Induction of Anesthesia

Hossain¹,

Rahman²,

Rashid³

et al. 2019

KYAMC j.

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Background: Intravenous dexamethasone may produce perineal pruritus in some patients when administered as premedicant before induction of anesthesia. Objectives of study: This randomized, double-blind study was done to evaluate the efficacy of pretreatment of lignocaine on the incidence and severity of dexamethasone-induced perineal pruritus. Materials and methods: 100 patients were enrolled in this study and allocated randomly into two equal groups. Then, patients received intravenous medications in the following sequence before induction of anesthesia: in group I, injection lignocaine 1mg/kg diluted in 5 ml normal saline and in group II, 5 ml normal saline (placebo group), then one minute later, intravenous dexamethasone sodium phosphate 10 mg was given in all groups in 3 seconds and was observed the patient's response about perineal pruritus. The severity of perineal pruritus was graded based on the visual analog scale (VAS) as none (VAS 0), mild (VAS 1-3), moderate (VAS 4-6), or severe (VAS 7-10), and recorded the incidence and severity of perineal pruritus. Then general anesthesia was induced and continued as usual. Results: In terms of demographic data, the results of this study showed that there was no significant difference between patients in both groups (P>0.05). Overall incidence and severity of perineal pruritus in lignocaine group was significantly less, when compared with placebo group (P<0.05). Conclusion: It can be concluded that pretreatment with 1mg/kg intravenous lignocaine may effectively reduce the incidence and severity of dexamethasone induced perineal pruritus. KYAMC Journal Vol. 9, No.-4, January 2019, Page 144-147

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“…In 1992, Klygis [42] provided an interesting contribution to the topic, reporting perineal irritation in patients after receiving an IV bolus of dexamethasone in an emergency care setting after traumatic brain injury. Interestingly, the side effect was also observed in semi‐conscious patients, ruling out the possibility of a suggestible response.…”

Section: Discussionmentioning

confidence: 99%

Generalized Pruritus as an Unusual Side Effect After Epidural Injection With Dexamethasone

Pimentel

Amadera

2014

PM&R

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A 51-year-old man with lumbar radiculopathy underwent a right L5 transforaminal epidural steroid injection with dexamethasone. One minute after the injection, the patient experienced severe pruritus and burning, which began in the groin and then spread throughout his body. The symptoms resolved completely after 1 minute, and the patient was discharged without any complications. Although there are a small number of publications reporting perineal pruritus after intravenous administration of dexamethasone, to our knowledge there is no report of a generalized reaction to an epidural dexamethasone injection such as the one described here.

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Dexamethasone-induced perineal irritation in head injury

Cited by 17 publications

References 6 publications

A comparative study of intravenous lignocaine, dexamethasone and combination of lignocaine-dexamethasone in attenuating propofol induced pain

A comparative study of intravenous lignocaine, dexamethasone and combination of lignocaine-dexamethasone in attenuating propofol induced pain

Effect of Intravenous Lignocaine in Attenuating Dexamethasone Induced Perineal Pruritus During Induction of Anesthesia

Generalized Pruritus as an Unusual Side Effect After Epidural Injection With Dexamethasone

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