Dexamethasone-induced adipogenesis in primary marrow stromal cell cultures

Li, Yin; Li, Yuebai; Wang, Yisheng

doi:10.1097/00029330-200604010-00012

Cited by 103 publications

(65 citation statements)

References 26 publications

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“…Previously, researchers have shown that pioglitazone (LeckaCzernik et al, 2002;Sottile et al, 2004) or DEX (Hausman, 2003;Kim et al, 2007;Yin et al, 2006) can induce bone marrow stromal cell adipogenesis, but these studies have some differences from our study. In those researches, an adipogenic medium (with IBMX and insulin) is absolutely needed for pioglitazone or DEX to induce adipogenesis.…”

Section: Discussioncontrasting

confidence: 77%

Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

et al. 2008

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Section: Discussioncontrasting

confidence: 77%

Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

et al. 2008

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“…Similarly, previous studies reported that the glucocorticoids could affect the metabolism of bone marrow stromal cells and induce adipogenesis in these cells, which finally led to nontraumatic ONFH. [1415] Another study indicated that the actual time of onset of osteonecrosis in systemic lupus erythematosus patients was within the 1 st month of high-dose corticosteroid treatment. [16] As for prednisone, Chernetsky et al .…”

Section: Discussionmentioning

confidence: 99%

An epidemiological study of etiology and clinical characteristics in patients with nontraumatic osteonecrosis of the femoral head

et al. 2017

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Background:Osteonecrosis of the femoral head (ONFH) is a common disease with high disability rate. However, a few studies investigate the etiology and clinical characteristics of nontraumatic ONFH patients in China. Therefore, we conducted this cross-sectional study.Materials and Methods:Totally, information of 7268 nontraumatic ONFH patients treated between August 2005 and August 2015 was extracted from the medical records. The extracted information included the age, gender, diagnostic criteria, cause of nontraumatic ONFH, types of steroid use, and types of alcohol.Results:Among these included patients, there were 5126 (70.5%) male patients with average age of 44.5 years and 2142 (29.5%) female patients with average age of 47.6 years (P = 0.54). The number of steroid-, alcohol-, steroid/alcohol-, and idiopathic-induced nontraumatic ONFH men patients was 1684, 2310, 364, and 768, respectively, and nontraumatic ONFH women patients was 1058, 482, 140, and 462, respectively. Meanwhile, we found that both the levels of triglycerides (P = 0.03) and low-density lipoprotein (P = 0.02) were significantly changed in the idiopathic-induced nontraumatic ONFH patients.Conclusion:These results indicated the earlier onset of nontraumatic ONFH in male patients than in female patients, different main etiology for male (alcohol consumption) and female (steroid use) patients, and close relationship between the lipid metabolism and idiopathic-induced nontraumatic ONFH. Our findings could be helpful for researchers to investigate the pathogenesis of ONFH and aid the clinicians in the early prevention and diagnosis of nontraumatic ONFH.

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“…We were also aware that many patients with joint pain are treated by anti-inflammatory steroid medications (intra-articular and oral), and that chronic steroid use can lead to bone porosis and increased risk of fracture. [34][35][36] A secondary aim of this study was to determine whether episodic steroid administration, or other patientspecific parameters (gender, smoking), influences subchondral bone properties and marrow access in MFX holes.…”

Section: Microfracture (Mfx) Is Used To Resurface Focal Outerbridgementioning

confidence: 99%

Characterization of Initial Microfracture Defects in Human Condyles

et al. 2013

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Microfracture (MFX) is a cartilage repair technique that depends on cell migration from marrow-rich trabecular bone cavities into the cartilage lesion. This study tested the hypothesis that MFX awls with distinct geometry generate different hole shapes and variable bone marrow access in condyles with Grade III to IV lesions. Lateral and medial condyles from total knee arthroplasty (N = 24 male and female patients, 66 ± 9 years) were systematically microfractured ex vivo to 2 and 4 mm deep and the bone holes analyzed by micro-computed tomography. Subchondral bone in lesional condyles showed different degrees of sclerosis up to 2 mm deep ("porous," sclerotic, extremely dense). MFX holes ranged from 1.1 to 2.0 mm in diameter, and retained the awl shape with evidence of slight bone elastic rebound and bone compaction lining the holes that were increased by wider awl diameter and deeper MFX. Marrow access was significantly diminished by sclerosis for all three awls, with an average marrow access varying from 70% (nonlesional bone) to 40% (extremely dense bone). This study revealed that subchondral bone sclerosis can reach a critical limit beyond which MFX creates bone compaction and fissures instead of marrow access.

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Dexamethasone-induced adipogenesis in primary marrow stromal cell cultures

Cited by 103 publications

References 26 publications

Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

An epidemiological study of etiology and clinical characteristics in patients with nontraumatic osteonecrosis of the femoral head

Characterization of Initial Microfracture Defects in Human Condyles

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