Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions

Hayward, Ryan C.; Utada, Andrew S.; Dan, Nily; Weitz, David A.

doi:10.1021/la060094b

Cited by 157 publications

(196 citation statements)

References 35 publications

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“…[71] Recent developments in microfluidics have enabled the directed self-assembly of monodisperse vesicles from water/oil/ water (w 1 /o/w 2 ) double emulsions. [72][73][74] Surprisingly many 'homopolymers' can also undergo self-assembly into stable vesicles if they posses sufficient A. Blanazs, S. P. Armes, A. J. Ryan Table 1.…”

Section: Block Copolymer Vesiclesmentioning

confidence: 99%

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Blanazs

Armes

Ryan

2009

Macromol. Rapid Commun.

1,392

1,370

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The ability of amphiphilic block copolymers to self‐assemble in selective solvents has been widely studied in academia and utilized for various commercial products. The self‐assembled polymer vesicle is at the forefront of this nanotechnological revolution with seemingly endless possible uses, ranging from biomedical to nanometer‐scale enzymatic reactors. This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.magnified image

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Section: Block Copolymer Vesiclesmentioning

confidence: 99%

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Blanazs

Armes

Ryan

2009

Macromol. Rapid Commun.

1,392

1,370

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“…The aim of this research [17][18][19] was to produce aqueous solutions of monodisperse vesicles from block copolymers in water-oil-water double emulsions by evaporating the oil.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic droplets in amphiphilic bilayers: a coarse-grained mean-field theory study

Greenall

Marques

2012

Soft Matter

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Hydrophobic molecules such as oils and certain drugs can be encapsulated between the two leaflets of an amphiphilic bilayer in both lipid and polymer systems. We investigate the case where the hydrophobic molecules are incompatible with the amphiphile tails and so form droplets. Using a coarse-grained mean-field model (self-consistent field theory, or SCFT), we find that droplets of a wide range of sizes have the same characteristic lens shape, and explain this result in terms of simple capillarity arguments, consistent with the measured variations of surface concentrations of amphiphile in the bilayer and in the monolayers that cover the droplet. We study the effect of the strength χ BO of the repulsion between the hydrophobic liquid and the amphiphile tails on the droplet shape, and find a gradual flattening of the droplet as χ BO is reduced. The droplet remains at least metastable even at very low values of χ BO . This is in contrast to the behavior as the length of the hydrophobic molecules is varied. Specifically, if these molecules are at least as long as the amphiphile tails, increasing their length further is found to have little effect on the droplet shape, while reducing their length below this value quickly causes the droplet to become unstable.

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“…The simple structures that satisfy this requirement are diblock copolymers and phospholipids that have hydrophilic and hydrophobic groups. Before the double emulsion drops form vesicles, the solvents in the middle phase need to be removed, for instance, through solvent evaporation [63][64][65]. Nevertheless, the double emulsion drops should maintain their stability during the solvent removal step.…”

Section: Microfluidic Approaches For Fabrication Of Vesiclesmentioning

confidence: 99%

Microfluidic Fabrication of Vesicles

Shum

Thiele

Kim

2013

Advances in Transport Phenomena

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Vesicles are compartments enclosed by a thin membrane, which is made up of amphiphilic molecules arranged into ordered layers. Vesicle-like structures are Nature's choice for encapsulating important biochemical species that enable living processes, and are increasingly important as artificial structures for the encapsulation and release of drugs, biomolecules and other active ingredients for biomedical, pharmaceutical, food and consumer industries. Advances in microfluidic technologies have provided a new set of tools for unraveling the science behind formation of vesicles and fabricating novel vesicles. While traditional approaches for fabricating vesicles rely on self-assembly of amphiphiles, the precise control of flow afforded in microfluidic devices enables directed assembly of the amphiphiles. Thus, techniques such as hydrodynamic flow focusing, controlled emulsion-templating and pulsatile jetting offer unprecedented degree of control over vesicle structures. This creates new opportunities to engineer the structures of vesicles and tailor them for specific applications. In this review, we introduce current understanding behind different kinds of vesicles, survey conventional and microfluidic techniques for their formation, discuss new approaches of encapsulation and release of active ingredients in microfluidic vesicles, and point to future research and development in the area.

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Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions

Cited by 157 publications

References 35 publications

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Hydrophobic droplets in amphiphilic bilayers: a coarse-grained mean-field theory study

Microfluidic Fabrication of Vesicles

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