Dewetting and spreading transitions for active matter on random pinning substrates

Sándor, Cs.; Libál, A.; Reichhardt, C.

doi:10.1063/1.4983344

Cited by 22 publications

(11 citation statements)

References 35 publications

(35 reference statements)

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“…The case 0 < α + β < 1 is analogous to the finding of Chechkin and colleagues [11,14,82,15,72]. On the other hand, the case 1 < α + β < 2 can depict many phases in [76] for certain pinning forces at low disk activity. The probability density (3.3) transition regime in the short-time limiting included in the Cattaneo-type equation is clear in the blue curve, where 0 < α + β < 1.…”

Section: Generalised Cattaneo Equation Of Type Isupporting

confidence: 70%

“…The reader is also referred to generalisations of diffusion, Fokker-Planck, and diffusion-wave equations by introduction of a generalised memory kernel [73,74,75]. However, recent numerical simulations have shown different transitions from superdiffusion to subdiffusion which are not, in all cases, covered by equation (1.7), see e.g., quasiperiodic interacting systems [38] and dewettingspreading-wetting transitions of self-propelled (run-and-tumble) clustered disks in a substrate with randomly placed pinning sites [76].…”

Section: Introductionmentioning

confidence: 99%

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Crossover Dynamics from Superdiffusion to Subdiffusion: Models and Solutions

Awad

Metzler

2020

Fract Calc Appl Anal

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The Cattaneo or telegrapher’s equation describes the crossover from initial ballistic to normal diffusion. Here we study and survey time-fractional generalisations of this equation that are shown to produce the crossover of the mean squared displacement from superdiffusion to subdiffusion. Conditional solutions are derived in terms of Fox H-functions and the δth-order moments as well as the diffusive flux of the different models are derived. Moreover, the concept of the distribution-like is proposed as an alternative to the probability density function.

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Section: Generalised Cattaneo Equation Of Type Isupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Crossover Dynamics from Superdiffusion to Subdiffusion: Models and Solutions

Awad

Metzler

2020

Fract Calc Appl Anal

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“…"Quite generally" one observes accumulation of active particles at a purely repulsive "hard" wall or impenetrable obstacles [2,23]. This has led to numerical searches for surface phase transitions in 2D models of active matter [24][25][26][27]. For a 2D lattice gas, hard walls lead to a completely wet state having θ ¼ 0 [27].…”

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confidence: 99%

Wetting Transition of Active Brownian Particles on a Thin Membrane

Turci

Wilding

2021

Phys. Rev. Lett.

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We study nonequilibrium analogues of surface phase transitions in a minimal model of active particles in contact with a purely repulsive potential barrier that mimics a thin porous membrane. Under conditions of bulk motility-induced phase separation, the interaction strength ε w of the barrier controls the affinity of the dense phase for the barrier region. We uncover clear signatures of a wetting phase transition as ε w is varied. In common with its equilibrium counterpart, the character of this transition depends on the system dimensionality: a continuous transition with large density fluctuations and gas bubbles is uncovered in 2D while 3D systems exhibit a sharp transition absent of large correlations.

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“…Even in case of S<0, the film does not dewet immediately when located in a metastable state, e.g., when temperature is below Preprints (www.preprints.org) | NOT PEER-REVIEWED | Active matter wetting transition. Sándor et al (2017) showed that, in the presence of random pinning substrates, sterically interacting self-propelled disks exhibit transitions among different states. In particular, we are in front of an Preprints (www.preprints.org) | NOT PEER-REVIEWED |…”

mentioning

confidence: 99%

“…example of active matter wetting transition: starting from a phase of separated cluster state, the disks can spread out and homogeneously cover the substrate. This transition is regulated by disk density, substrate strength, cluster size (which dips at the wetting-dewetting transition) and fraction of sixfold coordinated particles (which drops when dewetting occurs) (Sándor et al, 2017).…”

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confidence: 99%

Towards Dewetting Monoclonal Antibodies for Therapeutical Purposes

Tozzi¹

2019

Preprint

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Dewetting transition -a concept borrowed from fluid mechanics -is a physiological process which takes place inside the hydrophobic pores of ion channels. This transient phenomenon causes a metastable state which forbids water molecules to cross the microscopic receptors' cavities. This leads to a decrease of conductance, a closure of the hole and, subsequently, severe impairment of cellular performance. We suggest that artificially-provoked dewetting transition in ion channels' hydrophobic pores could stand for a molecular candidate to erase detrimental organisms, such as viruses, bacteria and cancer cells. We describe a novel type of high-affinity monoclonal antibody, which: a) targets specific trans-membrane receptor structures of harmful or redundant cells; b) is equipped with lipophilic and/or hydrophobic fragments that prevent physiological water flows inside ion channels. Therefore, we achieve an artificial dewetting transition inside receptors' cavities which causes transmembrane ionic flows discontinuity, channel blockage and subsequent damage of morbid cells. As an example, we describe dewetting monoclonal antibodies targeting the M2 channel of the Influenza A virus: they might prevent water to enter the pores, thus leading to virion impairment.In fluid mechanics, dewetting is a process occurring at solid-liquid or liquid-liquid interfaces. Dewetting stands for the rupture of the thin, liquid continuous film on the substrate's surface, leading to formation of irregular patterns of droplets. The opposite process is called spreading. Four stages can be recognized as dewetting proceeds (Sharmaa, 1996): (a) film rupture; (b) hole expansion and coalescence to form a polygonal "cellular" pattern. The dry patches augment when the material is gathered in the rim surrounding the growing hole; (c) disintegration of polymer ridges into spherical drops, due to Rayleigh instability. The droplets' size and spacing may vary over several orders of magnitude, since dewetting process starts from randomly formed holes inside the film. A two-tier surface exhibits a two-stage wetting transition: first impalement at microscale texture, then at nanoscale; (d) fingering instability of hole rims during their expansion (Sharmaa, 1996). This process, borrowed by physics, has been recently extended to describe also microscopic biological phenomena. In particular, dewetting transitions may occur inside the hydrophobic pores of cellular ion channels. In the narrowest, more hydrophobic parts of receptors' holes, a metastable state of dewetting transition forbids water molecules to get inside the cavities, leading to decrease in conductance, channel closure and impairment of cellular activities. We show how this peculiar process can be artificially produced to alter the physiological activity of noxious pathogens, such as viruses, bacteria and tumoral cells. In particular, we suggest the manufacture of monoclonal antibodies (against cellular receptors) equipped with lipophilic/hydrophobic caps. In the sequel, we will term these antibod...

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Dewetting and spreading transitions for active matter on random pinning substrates

Cited by 22 publications

References 35 publications

Crossover Dynamics from Superdiffusion to Subdiffusion: Models and Solutions

Crossover Dynamics from Superdiffusion to Subdiffusion: Models and Solutions

Wetting Transition of Active Brownian Particles on a Thin Membrane

Towards Dewetting Monoclonal Antibodies for Therapeutical Purposes

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