Devil’s Claw (Harpagophytum procumbens): An Anti-Inflammatory Herb with Therapeutic Potential

McGregor, GP; Fiebich, Bernd L.; Wartenberg, Andrea; Brien, Sarah; Lewith, George; Wegener, Tankred

doi:10.1007/s11101-004-2374-8

Cited by 41 publications

(34 citation statements)

References 14 publications

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“…However, H. zeyheri has a lower concentration of the biologically active constituents. It is often included in raw materials and products as an adulterant of H. procumbens, the preferred species of commerce (McGregor et al, 2005). Harpagophytum procumbens is a commercially important plant species for the national income of Namibia for example, where it was an estimated h1.06 million in 2009 (Ridgway and Krugmann, 2011).…”

Section: Introductionmentioning

confidence: 99%

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

Mncwangi

Chen

Vermaak

et al. 2012

Journal of Ethnopharmacology

116

104

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Section: Introductionmentioning

confidence: 99%

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

Mncwangi

Chen

Vermaak

et al. 2012

Journal of Ethnopharmacology

116

104

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“…The pharmacologically active components of H. procumbens are considered to be the iridoid glycosides, other constituents, such as phenylethanoid glycosides and flavonoids are considered to contribute to the pharmacological action [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis and stability of the constituents of Curcuma longa and Harpagophytum procumbens tinctures by HPLC-DAD and HPLC–ESI-MS

Karioti

Fani

Vincieri

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

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“…formulations of H. procumbens have shown good profi les for the inhibition of infl ammatory responses, although intraperitoneal administration provided the best supportive evidence in various in vivo studies (McGregor et al, 2005). However, some negative or non-signifi cant results have also been obtained in in vitro studies that tested varied extracts for their action on leukotrienes and prostaglandins in human or mouse blood.…”

Section: Introductionmentioning

confidence: 99%

Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw)

Ouitas

Heard

2009

Phytotherapy Research

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The current work compared the relative efficacies of six commercial formulations of H. procumbens. Each formulation was assayed for the content of harpagoside (1), harpagide (2), verbascoside (3) and 8-O-p-coumaroyl harpagide (4) and, based on the recommended dosages, the total daily amounts were determined and used to establish anti-/proinflammatory (A/P) factors. The formulations were compared using ex vivo porcine skin for their activities towards COX-2 by Western blotting. The results showed great variation in the amounts of compounds 1-4 within the six formulations examined. The relative proportions of 1-4 also varied widely between the products and this inconsistency was reflected in the A/P factors, which correlated with the COX-2 expression (R(2) = 0.9496). Although the data support the beneficial antiinflammatory effects from the use of some of the brands tested, others would appear potentially to exacerbate inflammation. To conclude, a ratio based upon the amount and relative proportions of anti- and proinflammatory compounds can be used to predict relative antiinflammatory properties. Also, with access to a diversity of ostensibly similar commercial products, the patient may experience varying therapeutic responses. Finally, current pharmacopoeia monographs, which are generally concerned with a minimum harpagoside content, are inadequate for ensuring the quality of products based on H. procumbens.

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Devil’s Claw (Harpagophytum procumbens): An Anti-Inflammatory Herb with Therapeutic Potential

Cited by 41 publications

References 14 publications

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

Analysis and stability of the constituents of Curcuma longa and Harpagophytum procumbens tinctures by HPLC-DAD and HPLC–ESI-MS

Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw)

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