Devices for Low-Resource Health Care

Richards‐Kortum, Rebecca; Odén, Maria

doi:10.1126/science.1243473

Cited by 44 publications

(41 citation statements)

References 12 publications

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“…Currently, in high-resource settings, new technologies are almost always incorporated as an addition to the standard of care; so, even though they may improve care, it is often at a higher cost (54). Low-resource settings face the necessity of defining a new standard of care, one where new technologies can be developed to provide the high-quality care for great value (55). Similar to the rapid expansion of cell phone networks in developing countries, which leapfrogged land lines, new technology—or health care models based on systems engineering principles—may leapfrog traditional medical exams, tools, and visits (56).…”

Section: Changing the Health Care Infrastructurementioning

confidence: 99%

Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

Boppart

Richards‐Kortum

2014

Sci. Transl. Med.

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Leveraging advances in consumer electronics and wireless telecommunications, low-cost, portable optical imaging devices have the potential to improve screening and detection of disease at the point of care in primary health care settings in both low- and high-resource countries. Similarly, real-time optical imaging technologies can improve diagnosis and treatment at the point of procedure by circumventing the need for biopsy and analysis by expert pathologists, who are scarce in developing countries. Although many optical imaging technologies have been translated from bench to bedside, industry support is needed to commercialize and broadly disseminate these from the patient level to the population level to transform the standard of care. This review provides an overview of promising optical imaging technologies, the infrastructure needed to integrate them into widespread clinical use, and the challenges that must be addressed to harness the potential of these technologies to improve health care systems around the world.

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Section: Changing the Health Care Infrastructurementioning

confidence: 99%

Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

Boppart

Richards‐Kortum

2014

Sci. Transl. Med.

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“…The steps involved in this transition, from design to adoption to wide‐scale introduction, should be evidence‐based. The evidence generation process must provide the information needed to guide product development with the aim of addressing an unmet need, to ensure timely regulatory approval and market development, and to increase the likelihood of patient and provider acceptance and uptake …”

Section: Introductionmentioning

confidence: 99%

From design to adoption: generating evidence for new technology designed to address leading global health needs

Merialdi

Armbrust

Ayres-de-Campos

et al. 2017

BJOG

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“…Furthermore, some prostatectomy patients suffer impairment of cavernous nerves, resulting in erectile dysfunction [4][5][6][7]. Based on the need for in vivo cancer diagnosis at sub-cellular resolution for robotic surgery, a miniaturized, multimodal, nonlinear, endo-microscopy probe has been developed to identify malignant prostate tissue and tumor margin by resolving differences in cellular and subcellular structures among tissue types, without the need for optical labels or contrast agents [8,9]. Epithelial cells, including prostate tumor cells, are rich in CH 2 bonds due to abundant lipid content.…”

Section: Introductionmentioning

confidence: 99%

Multimodal nonlinear endo-microscopy probe design for high resolution, label-free intraoperative imaging

McCormick³

et al. 2015

Biomed. Opt. Express

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We present a portable, multimodal, nonlinear endo-microscopy probe designed for intraoperative oncological imaging. Application of a four-wave mixing noise suppression scheme using dual wavelength wave plates (DWW) and a polarization-maintaining fiber improves tissue signal collection efficiency, allowing for miniaturization. The probe, with a small 14 mm transversal diameter, includes a customized miniaturized two-axis MEMS (micro-electromechanical system) raster scanning mirror and microoptics with an illumination laser delivered by a polarization-maintaining fiber. The probe can potentially be integrated into the arms of a surgical robot, such as da Vinci robotic surgery system, due to its minimal cross sectional area. It has the ability to incorporate multiple imaging modalities including CARS (coherent anti-Stokes Raman scattering), SHG (second harmonic generation), and TPEF (two-photon excited fluorescence) in order to allow the surgeon to locate tumor cells within the context of normal stromal tissue. The resolution of the endo-microscope is experimentally determined to be 0.78 µm, a high level of accuracy for such a compact probe setup. The expected resolution of the as-built multimodal, nonlinear, endo-microscopy probe is 1 µm based on the calculation tolerance allocation using Monte-Carlo simulation. The reported probe is intended for use in laparoscopic or radical prostatectomy, including detection of tumor margins and avoidance of nerve impairment during surgery. "Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy," Biomed. Opt. Express 2(4), 915-926 (2011). 44. X. Xu, J. Cheng, M. J. Thrall, Z. Liu, X. Wang, and S. T. C. Wong, "Multimodal non-linear optical imaging for label-free differentiation of lung cancerous lesions from normal and desmoplastic tissues," Biomed. Opt. Express 4(12), 2855-2868 (2013).

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Devices for Low-Resource Health Care

Abstract: Devices designed for low-resource settings can improve access to life-saving health care around the world.

Cited by 44 publications

References 12 publications

Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

From design to adoption: generating evidence for new technology designed to address leading global health needs

Multimodal nonlinear endo-microscopy probe design for high resolution, label-free intraoperative imaging

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