Device modified trabeculectomy for glaucoma

Wang, Xue; Wang, Ruidi; Coleman, Anne L.

doi:10.1002/14651858.cd010472

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…These findings were similar to those of Martone et al [33] In patients with uncontrolled IOP by topical medical agents and with progressive visual field impairment, trabeculectomy represents the gold standard of surgical therapy. Different studies demonstrated that trabeculectomy lowers IOP efficiently, allowing better control of mean 24-h pressure, but it widely modifies ocular surface anatomy, causing a persistent clinical or subclinical inflammatory process [9,30]. In line with the literature [34] our experience demonstrates that eyes that underwent trabeculectomy were characterized by the presence of well-documented ocular surface chronic inflammation as showed in Fig.…”

Section: Discussionsupporting

confidence: 75%

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In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy

et al. 2020

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Purpose: Assessing the quality of the ocular surface by in vivo scanning laser confocal microscopy (IVCM) in primary open angle glaucoma (POAG) patients treated by Xen 45 Gel Stent, medical therapy and trabeculectomy. Methods: Retrospective, single-center, single-masked, comparative study including 60 eyes of 30 patients (mean age 61.16 ± 10 years) affected by POAG. Eyes were divided into 3 groups: Group 1 eyes underwent the Xen 45 Gel Stent procedure, Group 2 eyes were under medical therapy, Group 3 eyes were surgically treated by trabeculectomy. All patients underwent HRT II IVCM analysis of cornea, limbus, conjunctiva, sub-tenionian space and sclera. Results: The Xen 45 Gel stent, if properly positioned in the sub-conjunctival space preserves goblet cells and limits ocular surface inflammation. Regular corneal epithelial cells with micro-cysts, and normo-reflective sub-epithelial nerve plexus are documented by IVCM. In sub Tenon's implants an alternative lamellar intra-scleral filtration is detectable. Combined surgical procedures show a noticeable number of inflammatory cells with rare micro-cysts. Post-trabeculectomy inflammatory reaction is more evident than Xen 45 Gel Stent associated surgical procedures, but less than medical therapy where a conspicuous presence of Langerhans cells, peri-neural infiltrates, marked loss of goblet cells and fibrosis is visible. Conclusion: Ocular surface inflammation was more notable in topical therapy than after trabeculectomy, which itself causes more inflammation than XEN Gel stents.

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Section: Discussionsupporting

confidence: 75%

“…Generally, when medical treatment does not succeed in stabilizing the progression of the disease and visual field loss, or it is not tolerated for hypersensitive reactions, surgery becomes the only alternative [8]. Trabeculectomy remains the gold standard and the most commonly practiced one [9].…”

Section: Introductionmentioning

confidence: 99%

In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy

et al. 2020

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“…Medications and laser or incisional surgeries are conventional methods for reducing IOP. Trabeculectomy is the most common incisional surgical procedure, commonly performed in patients with medically uncontrolled glaucoma [ 4 , 5 ]. However, postoperative fibrosis that most commonly occurs at the episclera leading to bleb failure months or years after filtering glaucoma surgery has limited the success rate of the treatment [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Shen

Cai

et al. 2020

Journal of Ophthalmology

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Purpose. To determine the effectiveness and safety of trabeculectomy along with amniotic membrane transplantation (AMT) for glaucoma. Methods. This systematic review was performed using RevMan 5.3. We searched PubMed, EMBASE, and the Cochrane Library and included studies published until September 2019. The treatment group included patients with AMT and trabeculectomy (group A), and the control group had only trabeculectomy (group B). We only included randomized controlled trials. The outcomes were intraocular pressure (IOP), complete success rate, number of antiglaucoma medications, and complications. Results. Five studies, including 174 eyes (87 eyes in the AMT group and 87 eyes in the control group), were eligible in this review. The parameters had no significant difference in heterogeneity between the AMT and control groups preoperatively. In the AMT group, the mean IOP was significantly lower at 3 and 12 months after operation (P < 0.0001 and P = 0.02, respectively), while the number of complete successes in the AMT group was significantly higher at 6 and 12 months (P = 0.02 and P = 0.003, respectively) compared with the control group. Complications, including a flat anterior chamber and hyphema, appeared to be decreased in the AMT group compared to the control group (P = 0.02 and P = 0.02, respectively). No differences were observed in the number of antiglaucoma medications, hypotony, encapsulated bleb, or choroidal detachment. Conclusion. Compared with only trabeculectomy, it is more efficient and safer to add AMT to trabeculectomy during glaucoma filtering surgery.

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“…The treatment for glaucoma involves medical management eye drops (Sung et al, ), trabeculectomy or microsurgery (Wang, Khan, & Coleman, ), laser surgery (Mermoud et al, ; Zafar, Sharif, & Yasmin, ) and drainage implants. Figure depicts the different types of glaucoma treatments.…”

Section: Glaucoma Detection Methodsmentioning

confidence: 99%

Fundus image classification methods for the detection of glaucoma: A review

Saba

Bokhari

Sharif

et al. 2018

Microscopy Res & Technique

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Glaucoma is a neurodegenerative illness and is considered as a standout amongst the most widely recognized reasons for visual impairment. Nerve's degeneration is an irretrievable procedure, so the diagnosis of the illness at an early stage is an absolute requirement to stay away from lasting loss of vision. Glaucoma effected mainly because of increased intraocular pressure, if it is not distinguished and looked early, it can result in visual impairment. There are not generally evident side effects of glaucoma; thus, patients attempt to get treatment just when the seriousness of malady is advanced altogether. Determination of glaucoma often comprises of review of the basic crumbling of the nerve in conjunction with the examination of visual function capacity. This article shows the persistent illustration of glaucoma, its side effects, and the potential people inclined to this malady. The essence of this article is on different classification methods being utilized and proposed by various scientists for the identification of glaucoma. This article audits a few division and segmentation methodologies that are exceptionally useful for recognizable proof, identification, and diagnosis of glaucoma. The research related to the findings and the treatment is likewise evaluated in this article.

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Device modified trabeculectomy for glaucoma

Cited by 11 publications

References 42 publications

In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy

In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Fundus image classification methods for the detection of glaucoma: A review

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