Device-guided slow breathing alters postprandial oxidative stress in young adult males: A randomized sham-controlled crossover trial

Hunter, Stacy D.; Bernardi, Luciano; McAllister, Matthew J.; John, Dinesh; Rahimi, Mitra; Lopez, Micqauella R.

doi:10.1016/j.numecd.2022.10.002

Cited by 1 publication

(1 citation statement)

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“…Aliquots of blood samples were withdrawn at every 30 min interval while urine samples were collected at beginning (0 min) and 360 min after mixed meal challenge (i.e., HC, HP, and HF) from both subgroups. We hypothesized that the mixed meal challenges is predictive of diabetic complications (Panel 1) via the deep phenotyping of oxidative stress in urine and erythrocytes samples (Panel 2) 44 , 52 , 61 , 73 – 84 . B Pathways from the onset of diabetes mellitus towards the development of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

Nutritional load in post-prandial oxidative stress and the pathogeneses of diabetes mellitus

He,

Liu,

Huang

et al. 2024

npj Sci Food

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Diabetes mellitus affected more than 500 million of people globally, with an annual mortality of 1.5 million directly attributable to diabetic complications. Oxidative stress, in particularly in post-prandial state, plays a vital role in the pathogenesis of the diabetic complications. However, oxidative status marker is generally poorly characterized and their mechanisms of action are not well understood. In this work, we proposed a new framework for deep characterization of oxidative stress in erythrocytes (and in urine) using home-built micro-scale NMR system. The dynamic of post-prandial oxidative status (against a wide variety of nutritional load) in individual was assessed based on the proposed oxidative status of the red blood cells, with respect to the traditional risk-factors such as urinary isoprostane, reveals new insights into our understanding of diabetes. This new method can be potentially important in drafting guidelines for sub-stratification of diabetes mellitus for clinical care and management.

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