Device for simultaneous positron emission tomography, laser speckle imaging and RGB reflectometry: Validation and application to cortical spreading depression and brain ischemia in rats

Gramer, Markus; Feuerstein, Delphine; Steimers, André; Takagaki, Masatoshi; Kumagai, Tetsuja; Sué, Michael; Vollmar, Stefan; Kohl‐Bareis, Matthias; Backes, Heiko; Graf, Rudolf

doi:10.1016/j.neuroimage.2014.03.027

Cited by 10 publications

(13 citation statements)

References 65 publications

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“…Corresponding changes in vessel diameter have been detected by intravital microscopy of pial arteries (16,46,54,59,359,419,420). Moreover, several surface reflectance and light transmission studies have detected reduced CBV preceding the hyperemia (FIGURE 5A; component I), or notched or jittery upstroke, in multiple species including rats and cats (98,163,227,299,303,305,306,359,407,442,444,474,479,481). Indeed, dramatic capillary red blood cell slowing, flow arrest, and even transient disappearance of red blood cells from capillary segments have all been observed (FIGURE 5B; component I), lasting as long as a minute during SD, without any evidence for focal or diffuse capillary narrowing or constriction, compression or collapse, or occlusion (59,479,480,490,491,532).…”

Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 86%

“…Direct pial artery diameter measurements showed a corresponding dilation (25-120%) in most studies, which appeared to be more prominent in smaller caliber arterioles than larger ones (16, 38, 46, 59, 64, 65, 314, 315, 407, 419 -422, 439, 460, 461, 512, 513). Multispectral reflectance, near-infrared spectroscopy, light transmission, and intravascular fluorescence imaging studies also showed hyperemia during SD in rats and cats (FIG-URE 5A; component II) (18,81,163,195,227,351,407,474,528). Hyperemia was further confirmed by magnetic resonance imaging (MRI), where CBV increased by ϳ30% for 1-2 min with a latency of 15-20 s after the apparent diffusion coefficient (ADC) changes during the depolarization (71).…”

Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 86%

“…Many studies with sufficient spatiotemporal resolution have also observed an initial hypoperfusion coincident with the DC shift (FIGURE 4; component I) (17,86,90,114,119,124,128,131,150,152,154,163,179,186,257,260,343,352,376,385,389,394,406,424,443,456,460,474,490,491). When present, this transient vasoconstrictive tone usually decreases CBF by 5-30% for 5-30 s, and can either precede the hyperemia leading to an early dip in CBF, or be superimposed on the rising slope giving the response a notched or jittery upstroke.…”

Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 98%

“…Increased cerebral metabolic rate of glucose (CMRGlu) is detectable as early as the DC shift onset, reaches a peak at repolarization, and returns to normal levels after about 15 min (150,258). Multiple consecutive SDs can indeed double or triple CMRGlu in broad areas of cortex (163,226,320,332,433). As a result, tissue glucose decreases by 30 -60% and lactate increases by more than twofold at or within a minute of peak depolarization (68,69,143,150,226,237,238,262,321,329,394,411,416).…”

Section: Metabolic Impact Of Spreading Depressionmentioning

confidence: 99%

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Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

Ayata

Lauritzen

2015

Physiological Reviews

458

600

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Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of functional or vascular divisions, and lasts up to a minute in otherwise normal tissue. As such, SD is a radically different breed of electrophysiological activity compared with everyday neural activity, such as action potentials and synaptic transmission. Seventy years after its discovery by Leão, the mechanisms of SD and its profound metabolic and hemodynamic effects are still debated. What we did learn of consequence, however, is that SD plays a central role in the pathophysiology of a number of diseases including migraine, ischemic stroke, intracranial hemorrhage, and traumatic brain injury. An intriguing overlap among them is that they are all neurovascular disorders. Therefore, the interplay between neurons and vascular elements is critical for our understanding of the impact of this homeostatic breakdown in patients. The challenges of translating experimental data into human pathophysiology notwithstanding, this review provides a detailed account of bidirectional interactions between brain parenchyma and the cerebral vasculature during SD and puts this in the context of neurovascular diseases.

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Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 86%

Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 86%

Section: B Prototypical Cerebral Hemodynamic Response To Sdmentioning

confidence: 98%

Section: Metabolic Impact Of Spreading Depressionmentioning

confidence: 99%

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Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

Ayata

Lauritzen

2015

Physiological Reviews

458

600

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“…37 Importantly, this would provide additional dynamic spatial-temporal information on oxygen metabolism and glucose consumption in order to get a better understanding of this complex interaction in the context of perfusion changes and monitor the result of surgical interventions aimed at flow restoration with even greater effectiveness.…”

Section: Limitations and Perspectivesmentioning

confidence: 99%

Infarct prediction by intraoperative laser speckle imaging in patients with malignant hemispheric stroke

Hecht

Müller

Sandow

et al. 2015

J Cereb Blood Flow Metab

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Currently, a reliable method for real-time prediction of ischemia in the human brain is not available. Here, we took a first step towards validating non-invasive intraoperative laser speckle imaging (iLSI) for prediction of infarction in 22 patients undergoing decompressive surgery for treatment of malignant hemispheric stroke. During surgery, cortical perfusion was visualized and recorded in real-time with iLSI. The true morphological infarct extension within the iLSI imaging field was superimposed onto the iLSI blood flow maps according to a postoperative MRI (16 h [95% CI: 13, 19] after surgery) with three-dimensional magnetization-prepared rapid gradient-echo and diffusion-weighted imaging reconstruction. Based on the frequency distribution of iLSI perfusion values within the infarcted and non-infarcted territories, probability curves and perfusion thresholds of normalized cerebral blood flow predictive of eventual infarction or non-infarction were calculated. Intraoperative LSI predicted and excluded cortical ischemia with 95% probability at normalized perfusion levels below 40% and above 110%, respectively, which represented 73% of the entire cortical surface area. Together, our results suggest that iLSI is valid for (pseudo-) quantitative assessment of blood flow in the human brain and may be used to identify tissue at risk for infarction at a given time-point in the course of ischemic stroke.

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Advances in Speckle Metrology

Joenathan

Sirohi

Bernal

2015

The Optics Encyclopedia

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The field of speckle metrology has seen a surge in development in the past 10 years owing to advancements in digital cameras and computing power. For instance, a variety of digital speckle correlation (DSC) processes can now be performed in almost real time and therefore speckle techniques has found applications in nondestructive testing (NDT), biology, and medicine. New techniques in terms of optical arrangements and in extracting phase data have been introduced for measuring out‐of‐plane and in‐plane motions in digital speckle interferometry (DSPI) and digital speckle shear interferometry (DSSPI). DSC, DSPI, and DSSPI have also been combined to extend the range of measurements. In addition, quantitative analysis in speckle interferometry has seen a plethora of new software developments for conducting real‐time, accurate, complicated, fast, and repeatable measurements with ease. In addition, different methods to process speckle fringes have made analysis equivalent to that of classical interferometry, yet can be applied to all types of real‐world specimen.

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Device for simultaneous positron emission tomography, laser speckle imaging and RGB reflectometry: Validation and application to cortical spreading depression and brain ischemia in rats

Cited by 10 publications

References 65 publications

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

Infarct prediction by intraoperative laser speckle imaging in patients with malignant hemispheric stroke

Advances in Speckle Metrology

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