Device-based Therapy for Mitral Regurgitation and Ventricular Reshaping

Update on Percutaneous Treatment for HFrEF: A Great Armamentarium for a Poor Ventricular Function

“…At 6-month follow-up, significant reductions in MR degree and LV volumes with concomitant improvements in LVEF and clinical status were observed [ 93 ]. As suggested in a case report, since the beneficial effects are progressive over a short-term follow-up, its effectiveness, which initially depends on a mechanism that involves physically altering the size or shape of the ventricle, may be secondarily enhanced by inducing biological responses that result in progressive reverse modeling [ 94 ]. The AccuCinch System is currently under evaluation in the Randomized Clinical Evaluation of the AccuCinch Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (CORCINCH-HF) (NCT04331769) pivotal trial, which is a prospective, randomized, open-label, multicenter, international, clinical safety and efficacy investigation designed to enroll 400 symptomatic patients with LVEF 20–40% and LV end-diastolic diameter 55 mm.…”