Device-associated infection rates, bacterial resistance, length of stay, and mortality in Kuwait: International Nosocomial Infection Consortium findings

Al-Mousa, Haifaa H.; Omar, Abeer; Rosenthal, Víctor D.; Salama, Mona F.; Aly, Nasser Yehia A.; Noweir, Mohammad El-Dossoky; Rebello, Flavie Maria; Narciso, Dennis Malungcot; Sayed, Amani Fouad; Kurian, Anu; George, Sneha Mary; Mohamed, Amna Mostafa; Ramapurath, Ruby Jose; Varghese, Suga Thomas

doi:10.1016/j.ajic.2015.10.031

Cited by 53 publications

(36 citation statements)

References 16 publications

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“…The indicated treatment for CoNS BSI included intravenous antibacterial therapy for at least 5 days after the date of the blood culture (or until death) [1, 4]. We defined all concurrent infectious foci, including NEC, ventilator associated pneumonia (VAP), central line-associated bloodstream infection (CLABSI), and meningitis according to the U.S. Centers for Disease Control and Prevention’s (CDC’s) National Healthcare Safety Network (NHSN) definitions [8, 18–20]. Only cases with NEC ≥ stage IIA in modified Bell’s criteria (definite NEC) were enrolled, and clinically defined VAP cases were considered [8].…”

Section: Methodsmentioning

confidence: 99%

Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Tsai

Lai

et al. 2017

BMC Infect Dis

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BackgroundNeonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated with a focus of infection. This distinction is not well characterized.MethodsAll patients with neonatal late-onset sepsis (LOS) between January 2006 and December 2013 were enrolled. LOS was categorized as a BSI with a concurrent focus of infection if LOS occurred before or within 24 h after the diagnosis of a specific infectious entity, and as “primary bacteremia” if no concurrent focus of infection was identified. Data concerning demographics, hospital course, microbiology, and outcomes were compared via univariate and multivariate analyses.ResultsOf 948 episodes of neonatal LOS, 781 (82.4%) were primary bacteremia, whereas 167 (17.6%) were associated with a known focus of infection, including meningitis (n = 51, 5.4%), ventilator-associated pneumonia (VAP) (n = 36, 3.8%), catheter-related bloodstream infections (n = 57, 6.0%), and necrotizing enterocolitis (NEC) (n = 21, 2.2%). The majority of NEC-associated BSIs were caused by gram-negative bacilli (85.7%). Group B streptococcus accounted for nearly one-third of all meningitis cases (29.4%). Although sepsis-attributable mortality was comparable between primary bacteremia and neonatal BSIs with a focus of infection, neonatal BSIs with meningitis, VAP, and NEC had significantly higher rates of infectious complications. The independent risk factors of sepsis-attributable mortality were infectious complications (Odds ratio [OR] 6.98; 95% confidence interval [CI] 3.64–13.39, P < 0.001); history of one or more than one previous episode(s) of BSI (OR 2.40 and 7.40; 95% CI 1.21–4.74 and 3.70–14.78, P = 0.012 and <0.001, respectively); and underlying secondary pulmonary hypertension in neonates (OR 4.77; 95% CI 1.91–11.96, P = 0.001).ConclusionsA considerable proportion of neonatal LOS can be associated with known infectious foci in the NICU. The microbiologic etiology of neonatal LOS with a concurrent focus of infection is significantly different from that of primary bacteremia. Neonatal BSIs with concurrent meningitis, VAP, or NEC are significantly more likely to have infectious complications. This association independently leads to sepsis-attributable mortality.

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Section: Methodsmentioning

confidence: 99%

Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Tsai

Lai

et al. 2017

BMC Infect Dis

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“…Infection or sepsis remains as a challenge in hospitalization, and severe infection and septic shock are also major causes of hospital mortality [1]. Despite extensive research and development in the understanding and treatment of infection and sepsis, the incidence of these conditions is still increasing [2].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil CD64 Index as a superior biomarker for early diagnosis of infection in febrile patients in the hematology department

Xiong

Wang

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…It was stated by the International Nosocomial Infection Control Consortium that the pooled rate of central line-associated blood stream infections in the intensive care units in Latin America, Asia, Africa, and Europe were 4.9 per 1,000 central line days, nearly fivefold higher than the rate reported from comparable US intensive care units. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days), as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days) 1–3. HCAIs are also associated with increased length of hospital stay,4,5 and the emergence of multidrug-resistant bacteria 6…”

Section: Introductionmentioning

confidence: 99%

Knowledge, awareness, and attitude regarding infection prevention and control among medical students: a call for educational intervention

Ibrahim

Elshafie

2016

AMEP

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BackgroundMedical students can be exposed to serious health care-associated infections, if they are not following infection prevention and control (IPC) measures. There is limited information regarding the knowledge, awareness, and practices of medical students regarding IPC and the educational approaches used to teach them these practices.AimTo evaluate the knowledge, awareness, and attitude of medical students toward IPC guidelines, and the learning approaches to help improve their knowledge.MethodsA cross-sectional, interview-based survey included 73 medical students from Weill Cornell Medical College, Qatar. Students completed a questionnaire concerning awareness, knowledge, and attitude regarding IPC practices. Students’ knowledge was assessed by their correct answers to the survey questions.FindingsA total of 48.44% of the respondents were aware of standard isolation precautions, 61.90% were satisfied with their training in IPC, 66.13% were exposed to hand hygiene training, while 85.48% had sufficient knowledge about hand hygiene and practiced it on a routine basis, but only 33.87% knew the duration of the hand hygiene procedure.ConclusionKnowledge, attitude, and awareness of IPC measures among Weill Cornell Medical Students in Qatar were found to be inadequate. Multifaceted training programs may have to target newly graduated medical practitioners or the training has to be included in the graduate medical curriculum to enable them to adopt and adhere to IPC guidelines.

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Device-associated infection rates, bacterial resistance, length of stay, and mortality in Kuwait: International Nosocomial Infection Consortium findings

Cited by 53 publications

References 16 publications

Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

Neutrophil CD64 Index as a superior biomarker for early diagnosis of infection in febrile patients in the hematology department

Knowledge, awareness, and attitude regarding infection prevention and control among medical students: a call for educational intervention

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