Developments towards synthesis of N-heterocycles from amidinesviaC–N/C–C bond formation

Abstract

This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis on the mechanisms of these reactions via C–N/C–C bond formation.

Synthesis of Sulfamate‐Fused 2‐Aminopyrroles via an Isocyanide‐Based Three Component [1+2+2] Annulation

“…This reaction proceeds smoothly without any activation or modification of substances under neutral and metal-free conditions. The reactionc oulda lso be convenientlyp erformed on ag ram scale.Nitrogen-containing heterocyclesa re the mostr emarkable scaffoldss ince they are prevalent in variousn atural compounds, [1] pharmaceuticals, [2] agrochemicals [3] as well as synthetic bioactivem olecules. [4] Amongt he vast array of heterocycle compounds, fused pyrroles and polysubstituted pyrroles are particularly fascinating motifs and exhibit broad bioactivities.…”

Atmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes

“…[11] An alternative strategy focuseso nt he generation of thiyl radicals and subsequent anti-Markovnikov addition onto an alkene (thiol-ene reaction). [12][13][14] This latter strategy is highly effective and has seen widespread application.I ndeed, the efficiency of this process renders it suitable as a" click" reaction and thus the thiol-ene reaction has seen applications in fields ranging from materials science to glycoscience and protein labelling. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] There are aw ide variety of reported approaches for the formationo ft hiyl radicals, however the most frequently utilized are:( i) Hydrogen atom abstraction (HAA) from at hiol and;( ii) homolytic cleavage of weak SÀXb onds (X = halide, S, Se, etc.).…”

A comparison of the catalytic efficiency of copper-based bimetallic nanoparticles in the click reactions

“…Triazoles, as a type of significantly useful N -heterocycles, 1–5 have been widely applied in fluorescent materials, drug discovery, chemosensing, biochemistry, dendrimers, agricultural products, materials science, corrosion-retarding agents, dyes, and polymer chemistry, 6–8 due to the physically and chemically inertness against reduction, oxidation and hydrolysis under basic or acidic conditions. 9 Plenty of methods have been developed for the synthesis of 1,2,3-triazoles.…”