Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan

Miller, Bradley; Blair, Jo; Horikawa, Reiko; Linglart, Agnès; Yuen, Kevin

doi:10.2147/dddt.s315172

Cited by 4 publications

(1 citation statement)

References 48 publications

(159 reference statements)

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“…Pituitary hormone replacement therapy is usually performed by administration of the corresponding peripheral gland hormone (thyroxine, hydrocortisone), as there are no orally available drugs for ACTH or TSH [ 47 , 48 ]. Sex steroids are replaced by depot injections, orally, or transdermally while GH replacement therapy requires daily (or soon weekly) subcutaneous injections [ 47 , 49 ] (Fig. 1 ).…”

Section: Approach To Hospitalized Patients With Hypopituitarismmentioning

confidence: 99%

Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management

Ebrahimi,

Andereggen,

Christ

2024

Rev Endocr Metab Disord

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Hypopituitarism is a highly heterogeneous multisystem disorder that can have a major impact on long-term morbidity and mortality, but even more so during acute medical conditions requiring hospitalization. Recent studies suggest a significant in-hospital burden with prolonged length of stay, increased rate of intensive care unit (ICU) admission, and initiation of mechanical ventilation − all of which may lead to an increased risk of in-hospital mortality. On the one hand, patients with hypopituitarism are often burdened by metabolic complications, including obesity, hypertension, dyslipidemia, and hyperglycemia, which alone, or in combination, are known to significantly alter relevant physiological mechanisms, including metabolism, innate and adaptive immune responses, coagulation, and wound healing, thereby contributing to adverse in-hospital outcomes. On the other hand, depending on the extent and the number of pituitary hormone deficiencies, early recognition of hormone deficiencies and appropriate management and replacement strategy within a well-organized multidisciplinary team are even stronger determinants of short-term outcomes during acute hospitalization in this vulnerable patient population. This review aims to provide an up-to-date summary of recent advances in pathophysiologic understanding, clinical implications, and recommendations for optimized multidisciplinary management of hospitalized patients with hypopituitarism.

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