Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy

Abstract

SummaryIn the second of two papers, we describe developments in the field of clinical allergy as documented by Clinical and Experimental Allergy in 2015. Epidemiology, clinical allergy, asthma and rhinitis are all covered.In this second of two reviews, we discuss the new findings in the field of allergy in 2015 focusing on clinical aspects. These highlight the contribution published in Clinical and Experimental Allergy. We focus on epidemiology, clinical allergy, asthma and rhinitis. Epidemiology GeneralThe research field of allergy-related diseases is complex since we often lack firm data on exposure, and outcome is not easy to estimate as diagnosis is often more subjective compared to other disease areas. Additionally we lack high-quality registries. Such registries are based on a doctor's willingness to enter patient data. Such registers give us a good description of entered patients although we do not know what data are excluded. However, the situation is improving with i-technology. In some EU countries, there are now inpatient, outpatient and national registers including registers for twins. However, a lot of information for epidemiological research in the field of allergy related diseases is still based on questionnaire data, where the quality of the collected information is not always known.

Protease‐activated receptor‐2 suppresses interleukin (IL)‐10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis

“…The prevalence of allergic disease, such as allergic rhinitis (AR), allergic asthma, and allergic dermatitis, is rapidly rising in the past decades . The mechanism of allergy is not fully understood yet . The main pathological feature of allergy is the T helper (Th) 2 polarization, including the increase in Th2 cells, and the Th2 cells overproduce Th2 cytokines .…”

“…Allergy is the hypersensitivity of the immune system to allergens, which usually are harmless to healthy people. The prevalence of allergic disease, such as allergic rhinitis (AR), allergic asthma, and allergic dermatitis, is rapidly rising in the past decades . The mechanism of allergy is not fully understood yet .…”

“…1,2 The mechanism of allergy is not fully understood yet. 2 The main pathological feature of allergy is the T helper (Th) 2 polarization, including the increase in Th2 cells, and the Th2 cells overproduce Th2 cytokines. 3 Another pathological feature of allergy is the compromise of immunotolerance.…”

Welcome to Clinical and Experimental Allergy in 2017

“…So it looks like multiple factors alter the impact of dog exposure in early life on the development of allergic diseases. This might explain why different studies have not provided a consistent answer to the question of whether dog exposure impacts on the development of allergy .

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