Developments in the assessment of glomerular filtration rate

Price, Christopher P.; Finney, Hazel

doi:10.1016/s0009-8981(00)00233-3

Cited by 118 publications

(58 citation statements)

References 44 publications

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“…In patients with CRF, trends of renal function over time are determined using one of several approximations of GFR based on serum creatinine (2)(3)(4). These approximations, however, perform adequately only in advanced disease (GFR Ͻ60 ml/min per 1.73 m 2 ) (4 -6).…”

mentioning

confidence: 99%

“…The current methods for detecting trends in renal function in this range involve direct measurements of GFR based on intravenous infusion of an exogenous marker (e.g., iothalamate, the reference method used in this study), and none is simple enough for use in clinical or epidemiologic studies (2,3). The procedures are time-consuming, costly, and susceptible to measurement error (2).…”

mentioning

confidence: 99%

“…The procedures are time-consuming, costly, and susceptible to measurement error (2). For routine clinical use, a simple measure that is based on an endogenous marker is needed-similar to serum creatinine but without its limitations (1)(2)(3).…”

mentioning

confidence: 99%

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Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration

Perkins

Nelson²,

Ostrander³

et al. 2005

Journal of the American Society of Nephrology

303

227

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Research on early renal function decline in diabetes is hampered by lack of simple tools for detecting trends (particularly systematic decreases) in renal function over time when GFR is normal or elevated. This study sought to assess how well serum cystatin C meets that need. Thirty participants with type 2 diabetes in the Diabetic Renal Disease Study met these three eligibility criteria: GFR >20 ml/min per 1.73 m 2 at baseline (based on cold iothalamate clearance), 4 yr of follow-up, and yearly measurements of iothalamate clearance and serum cystatin C. With the use of linear regression, each individual's trend in renal function over time, expressed as annual percentage change in iothalamate clearance, was determined. Serum cystatin C in mg/L was transformed to its reciprocal (100/cystatin C), and linear regression was used to determine each individual's trend over time, expressed as annual percentage change. In paired comparisons of 100/cystatin C with iothalamate clearance at each examination, the two measures were numerically similar. More important, the trends in 100/cystatin C and iothalamate clearance were strongly correlated (Spearman r ‫؍‬ 0.77). All 20 participants with negative trends in iothalamate clearance (declining renal function) also had negative trends for 100/cystatin C. Results were discordant for only three participants. In contrast, the trends for three commonly used creatinine-based estimates of GFR compared poorly with trends in iothalamate clearance (Spearman r < 0.35). Serial measures of serum cystatin C accurately detect trends in renal function in patients with normal or elevated GFR and provide means for studying early renal function decline in diabetes.

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confidence: 99%

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confidence: 99%

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Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration

Perkins

Nelson²,

Ostrander³

et al. 2005

Journal of the American Society of Nephrology

303

227

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“…Cystatin C is a 13-kDa protein whose plasma concentration reflects GFR. Its superiority over serum creatinine in terms of diagnostic sensitivity for reduced GFR is generally accepted (13)(14)(15)(16)(17)(18)(19)(20)(21), but concerns have been expressed that it may be affected by malignant progression (22)(23)(24)(25)(26). To our knowledge, neither cystatin C nor the MDRD formulas have been evaluated against a gold standard measure of GFR in patients with multiple myeloma.…”

mentioning

confidence: 99%

Diagnostic Accuracy of Cystatin C as a Marker of Kidney Disease in Patients with Multiple Myeloma: Calculated Glomerular Filtration Rate Formulas Are Equally Useful

Lamb¹,

Stowe²,

Simpson³

et al. 2004

Clinical Chemistry

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“…Despite several studies suggesting that CC estimation could be used for the routine assessment of renal function, 5 it remains under evaluation. There is concern that, like b 2 M, CC could be a¡ected by cell proliferation disorders.…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of cystatin C is not affected by cellular proliferation in patients with proliferative haematological disorders

et al. 2002

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Developments in the assessment of glomerular filtration rate

Cited by 118 publications

References 44 publications

Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration

Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration

Diagnostic Accuracy of Cystatin C as a Marker of Kidney Disease in Patients with Multiple Myeloma: Calculated Glomerular Filtration Rate Formulas Are Equally Useful

Serum concentration of cystatin C is not affected by cellular proliferation in patients with proliferative haematological disorders

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