Developments in taxol production through endophytic fungal biotechnology: a review

Naik, B. Shankar

doi:10.1007/s13596-018-0352-8

Cited by 45 publications

(22 citation statements)

References 84 publications

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“…This compound was produced by several endophytic fungi in the genera Alternaria, Aspergillus, Beauveria, Cladosporium, Chaetomella, Fusarium, Guignadia, Monochaetia, Nodulisporium, Pestlotia, Pestalotiopsis, Pithomyces, Penicillium, Phomopsis, Phyllostica, Sporormia, Taxomyces, Trichoderma, Trichothecium, Tubercularia, and Xylaria [61][62][63][64][65][66][67][68][69]. More than sixty endophytic fungal strains have been identified as paclitaxel producers [70,71]. Generally, paclitaxel has been used as an anticancer drug against breast cancer, non-small cell lung cancer, ovarian cancer, and prostate cancer [72,73].…”

Section: Hiv-1 Protease Inhibitors Isolated From Fungimentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.

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Section: Hiv-1 Protease Inhibitors Isolated From Fungimentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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“…The matured oocytes were selected and incubated in ND96 containing: 96 mM NaCl, 1 mM MgCl 2 , 2 mM KCl, 1.8 mM CaCl 2 , and 20 mM HEPES at pH 5.6 with 1% penicillin and streptomycin (Sigma). Two electrode voltage clamp experiments were carried out after 48 h for each of the RNA-injected oocytes (Naik, 2019). The oocyte was put in a perfusion chamber (Warner Instrument, Holliston, MA, USA) and flowed with ND96 medium at 1 mL/min.…”

Section: Methodsmentioning

confidence: 99%

Identification of Lysine Histidine Transporter 2 as an 1-Aminocyclopropane Carboxylic Acid Transporter in Arabidopsis thaliana by Transgenic Complementation Approach

et al. 2019

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1-Aminocyclopropane-1-carboxylic acid (ACC), a biosynthetic precursor of ethylene, has long been proposed to act as a mobile messenger in higher plants. However, little is known about the transport system of ACC. Recently, our genetic characterization of an ACC-resistant mutant with normal ethylene sensitivity revealed that lysine histidine transporter 1 (LHT1) functions as a transporter of ACC. As amino acid transporters might have broad substrate specificity, we hypothesized that other amino acid transporters including LHT1 paralogs might have the ACC-transporter activity. Here, we took a gain-of-function approach by transgenic complementation of lht1 mutant with a selected set of amino acid transporters. When we introduced transgene into the lht1 mutant, the transgenic expression of LHT2, but not of LHT3 or amino acid permease 5 (AAP5), restored the ACC resistance phenotype of the lht1 mutant. The result provides genetic evidence that some, if not all, amino acid transporters in Arabidopsis can function as ACC transporters. In support, when expressed in Xenopus laevis oocytes, both LHT1 and LHT2 exhibited ACC-transporting activity, inducing inward current upon addition of ACC. Interestingly, the transgenic expression of LHT2, but not of LHT3 or AAP5, could also suppress the early senescence phenotypes of the lht1 mutant. Taking together, we propose that plants have evolved a multitude of ACC transporters based on amino acid transporters, which would contribute to the differential distribution of ACC under various spatiotemporal contexts.

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“…Thus researchers aim at taxol production by means of several modern techniques including chemical synthesis, semi-synthesis method and plant tissue culture method. Nevertheless, these methods have both advantages and disadvantages (Ismaiel et al 2017; Shankar Naik 2019). Kusari et al (2012) reported that there has been tremendous interest in locating alternative sources of paclitaxel, including fungal endophytes (Kusari et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In general, microbial fermentation has demonstrated that isolation and identification of taxol-producing fungi is a good strategy in the production of taxol (Ismaiel et al 2017). Thus, developing a cost-effective paclitaxel fermentation process by microorganisms has become a sustainable solution (Shankar Naik 2019; Somjaipeng et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the cancer cells are arrested in the late G or M phase, mitosis of the cancer cells is inhibited, proliferation of the cancer cells is impeded, and the cells gradually shrink and eventually die. However, there are very few reports on other biological activities of paclitaxel such as inhibition of HIV-1 viral replication activity and regulation of immunity (Shankar Naik 2019; Wang et al 2015). Wang et al (2015) compared activities of taxol produced by endophytic fungi Nodulisporium sylviforme HDFS4-26 with that of taxol extracted from yew bark in inhibiting growth and inducing apoptosis of cancer cells (Wang et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique

et al. 2019

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In this study, a single component paclitaxel was obtained from fermentation broth by molecular imprinting technique, and its antiviral, antitumor and immunomodulatory activities were studied. The results showed that paclitaxel had a good inhibitory activity on human breast cancer MCF-7 cells and showed a concentration- dependent relationship with an IC50 of about 15 μg/mL in the sulforhodamine B assay. At the same time, paclitaxel exerted a weak inhibitory activity on cervical cancer Hela cells. In addition, paclitaxel not only inhibited the invasion of HIV-1 pseudovirus into cells, but also exhibited inhibitory activity to a certain extent after viral invasion of the cells. At a paclitaxel concentration of 20 μg/mL, the inhibition of HIV-1 pseudovirus reached about 66%. The inhibition of HIV-1 protease activity was concentration-dependent. At a concentration of 20 μg/mL, the inhibitory effect of paclitaxel on HIV-1 protease was similar to that of the positive control pepstatin A, being 15.8%. The HIV-1 integrase inhibiting activity of paclitaxel was relatively weak. Paclitaxel significantly up-regulated the expression of interleukin-6.

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Developments in taxol production through endophytic fungal biotechnology: a review

Cited by 45 publications

References 84 publications

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

Identification of Lysine Histidine Transporter 2 as an 1-Aminocyclopropane Carboxylic Acid Transporter in Arabidopsis thaliana by Transgenic Complementation Approach

Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique

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