Developments in Synthesis of the Anti-inflammatory Drug, Celecoxib: A Review

Kumar, Vinod; Kaur, Kiranjeet; Gupta, Girish Kumar; Gupta, A. K.; Kumar, Sunil

doi:10.2174/1872213x11307020004

Cited by 45 publications

(23 citation statements)

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“…Celecoxib is a selective COX-2 inhibitor that is rapidly absorbed, possesses good oral bioavailability, and has a short mean plasma half-life. The analgesic effect of celecoxib has been demonstrated in 16 both orthopedic and obstetric surgery [26][27][28][29]. Our findings indicate that all patients tolerated 4 days of celecoxib, and as a result, celecoxib provided stable pain relief following LG without any severe adverse effects in the liver, kidney, gastrointestinal tract, or hemocytes.…”

Section: Discussionmentioning

confidence: 50%

A comparison between fentanyl plus celecoxib therapy and epidural anesthesia for postoperative pain management following laparoscopic gastrectomy

et al. 2015

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Purpose To clarify the efficacy of postoperative pain management following laparoscopic gastrectomy (LG), we retrospectively compared pain assessments in patients who received fentanyl plus celecoxib with those who received epidural anesthesia. Results No significant difference in the severity of postoperative pain on postoperative day (POD) 0 or 1 was observed between the two groups. In contrast, pain was significantly lower in Group-FC than Group-E on POD 2, 3, 4, and 7. The total use of rescue pain medications during the first 7 days following LG did not differ between the two groups. Methods ConclusionPain management using 24 hours of intravenous fentanyl and 4 days of oral celecoxib is comparable to epidural anesthesia following LG.

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Section: Discussionmentioning

confidence: 50%

A comparison between fentanyl plus celecoxib therapy and epidural anesthesia for postoperative pain management following laparoscopic gastrectomy

et al. 2015

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“…Calcd. for C 14 C-NMR (100 MHz, DMSO-d 6 ): δ = 162.8 (C, C-7), 151.8 (C, C-3'), 141.4 (CH, C-6'), 140.7 (C, C-4), 139.0 (C, C-1''), tetramethylsilane (TMS) (δ=0) in CDCl 3 or DMSO-d 6 , and were reported on δ scale (ppm). Coupling constants (J) were given in Hz.…”

Section: Methodsmentioning

confidence: 99%

“…Pyrazole derivatives exhibited a broad spectrum of useful properties such as antitumor [11], antitubercular [12], antioxidant [13], anti-inflammatory [14,15], antibacterial [16], anti-obesity [17] and antidepressant [18] activities. Similarly, 1,3,4-oxadiazoles have been reported to exhibit various biological [19,20] and pharmacological activities [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Kumar¹,

Kumar²,

Beniwal³

et al. 2016

Med chem (Los Angeles)

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Some 2,5-disubstituted-1,3,4-oxadiazole derivatives have been synthesized conveniently via oxidative cyclization of various synthesized aroylhydrazones by (diacetoxyiodo)benzene in dichloromethane under mild reaction conditions. In addition, the effect of electron-withdrawing/releasing groups on the formation of oxadiazole nucleus has also been studied. Compounds were obtained in good yields and their structures have been established on the basis of their FT-IR, 1 H, 13 C NMR and mass spectral data. Herein, a total of 42 compounds (hydrazones as well as oxadiazoles) were synthesized and investigated for their DNA photocleavage potential using plasmid DNA. It has been observed that aroylhydrazones showed good DNA photocleavage activity in comparison to their corresponding oxadiazoles.

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“…Pyrazole and its derivatives are well known for their excellent biological properties [1][2][3][4]. In view of the importance of pyrazole nucleus, recently several synthetic routes have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Greener synthesis and DNA photocleavage activity of 1, 5-Diaryl-3-trifluoromethylpyrazole derivatives

Gupta

Kumar

Saini

2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

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1,5-Diaryl-3-trifluoromethypyrazole derivatives have acquired much attention in the past few years due to their good biological potential. In the present communication, some 1,5-diaryl-3-trifluoromethylpyrazoles were synthesized by one-pot solid phase reaction. The DNA photocleavage study of the synthesized compounds was performed using agarose gel electrophoresis method. To have better insight of how our ligands interacted with the DNA, molecular docking simulations through Autodock Vina were also performed. All the compounds have shown good binding with the DNA. It has been found that pyrazoles containing phenyl rings at both positions (1 and 5) possessing electron releasing as well as electron withdrawing groups enhance the DNA photocleavage potential. As the synthesized derivatives shown the promising DNA photocleavage activity, so they may serve the basis of some bioactive heterocycles in the future.

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Developments in Synthesis of the Anti-inflammatory Drug, Celecoxib: A Review

Cited by 45 publications

References 0 publications

A comparison between fentanyl plus celecoxib therapy and epidural anesthesia for postoperative pain management following laparoscopic gastrectomy

A comparison between fentanyl plus celecoxib therapy and epidural anesthesia for postoperative pain management following laparoscopic gastrectomy

Synthesis of Some Aroylhydrazones and 2,5-Disubstituted-1,3,4- Oxadiazoles as DNA Photocleaving Agents

Greener synthesis and DNA photocleavage activity of 1, 5-Diaryl-3-trifluoromethylpyrazole derivatives

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