Developments in metallic biodegradable stents☆

Hermawan, Hendra; Dubé, D.; Mantovani, Diego

doi:10.1016/j.actbio.2009.10.006

Cited by 518 publications

(292 citation statements)

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“…[4][5][6][7][8][9][10] Iron is also an essential element for proper biological functions, mainly for the transfer of oxygen by blood. 13 The recommended daily value of Fe is about 10 mg. 6 Regarding the biocompatibility of iron-based alloys, there are a number of reported results, [14][15][16] but they are often controversial. In order to explain the discrepancies between biocompatibility tests, more in-vitro and in-vivo experiments are needed.…”

Section: Introductionmentioning

confidence: 99%

“…Appropriate alloying of Mg, Zn and Fe can positively modify their mechanical, corrosion and physical properties, which are important for potential medical applications. In the available literature many alloying elements are proposed for these purposes, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] but in this study Mg-RE (RE = rare earth metals, Gd, Nd, Y), Zn-Mg and Fe-Mn based alloys were selected, because all these alloying systems are generally considered as relatively safe and acceptable for a potential medical use. 3 …”

Section: Introductionmentioning

confidence: 99%

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Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals

Vojtěch¹,

Kubásek²,

Čapek³

2015

Mater. Tehnol.

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In this paper, selected magnesium, zinc and iron biodegradable alloys were studied as prospective biomaterials for temporary medical implants like stents and fixation devices for fractured bones. Mechanical properties of the alloys were characterized with hardness and tensile tests. In-vitro corrosion behavior was studied using immersion tests in a simulated physiological solution (SPS, 9 g/L NaCl) to roughly estimate the in-vivo biodegradation rates of implants. It was found that the Mg and Zn alloys were limited by a tensile strength of 370 MPa, while the tensile strength of the Fe alloys achieved 530 MPa. The main advantage of the Mg alloys is that their Young's modulus of elasticity is similar to that of the human bone. However, the corrosion tests revealed that the Mg-based alloys showed the highest corrosion rates in the SPS, ranging between 0.6 mm and 4.0 mm per year, which is above the tolerable degradation rates of implants. The corrosion rates of the Zn alloys were between 0.3 mm and 0.6 mm per year and the slowest corrosion rates of approximately 0.2 mm per year were observed for the Fe alloys.The results indicate that all three kinds of alloys meet the mechanical requirements for the load-bearing implants. From the corrosion-behavior point of view, the Zn-and Fe-based "slowly corroding" alloys appear as promising alternatives to the Mg-based alloys. Keywords: biodegradable metal, magnesium, zinc, iron, mechanical properties, corrosion lanek obravnava {tudij izbranih magnezijevih, cinkovih in`elezovih potencialnih biorazgradljivih zlitin kot obetajo~ih biomaterialov za za~asne medicinske vsadke, kot so opornice in pripomo~ki za utrjevanje zlomljenih kosti. Mehanske lastnosti zlitin so bile dolo~ene z merjenjem trdote in z nateznimi preizkusi. Korozijski preizkusi in vitro so bili izvr{eni s pomakanjem v simulirano fiziolo{ko raztopino (SPS, 9 g/L NaCl) za grobo oceno in vivo hitrosti biorazgradnje implantatov. Ugotovljeno je, da so zlitine Mg in Zn omejene z natezno trdnostjo 370 MPa, medtem ko je natezna trdnost Fe-zlitin dosegla 530 MPa. Glavna prednost Mg-zlitin je v podobnem Young-ovem modulu elasti~nosti, ki je podoben kot pri~love{ki kosti. Vendar pa so korozijski preizkusi pokazali pri zlitinah na osnovi Mg najve~je korozijske hitrosti v SPS, med 0,6 mm in 4,0 mm na leto, kar je nad dopustno hitrostjo degradacije implantata. Korozijske hitrosti Zn zlitin so bile med 0,3 mm in 0,6 mm na leto, najni`je hitrosti korozije, okrog 0,2 mm na leto, pa so bile opa`ene pri Fe-zlitinah. Rezultati so pokazali, da vse tri vrste zlitin ustrezajo mehanskim zahtevam za obremenjene implantate. S stali{~a korozijskega vedenja so zlitine na osnovi Zn in Fe "zlitine s po~asno korozijo" in se ka`ejo kot obetajo~e nadomestilo za zlitine na osnovi Mg.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals

Vojtěch¹,

Kubásek²,

Čapek³

2015

Mater. Tehnol.

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“…Especially in the case of biodegradable stent applications, the degradation rate of the Mg alloy stent may be lower than the required period of 6 months for vessel remodeling. 4 The surface characteristics, which mainly consist of surface topography, chemistry, and wettability, play a crucial role on how the implant material interacts with the surrounding media. These interactions also involve corrosion rate and mechanism as well as biological response of the tissue to the implant material.…”

Section: Introductionmentioning

confidence: 99%

Laser surface structuring of AZ31 Mg alloy for controlled wettability

et al. 2014

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Structured surfaces exhibit functional properties that can enhance the performance of a bioimplant in terms of biocompatibility, adhesion, or corrosion behavior. In order to tailor the surface property, chemical and physical methods can be used in a sequence of many steps. On the other hand, laser surface processing can provide a single step solution to achieve the designated surface function with the use of simpler equipment and high repeatability. This work provides the details on the surface structuring of AZ31, a biocompatible and biodegradable Mg alloy, by a single-step laser surface structuring based on remelting. The surfaces are characterized in terms of topography, chemistry, and physical integrity, as well as the effective change in the surface wetting behavior is demonstrated. The results imply a great potential in local or complete surface structuring of medical implants for functionalization by the flexible positioning of the laser beam.

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“…In addition, the mechanical properties of pure iron are modest and not particularly well suited for the use as stent material. To accelerate degradation and improve mechanical properties, Hermawan et al [4][5][6] alloyed iron with manganese. The manganese has been chosen because it is less noble than iron, it is known as an austenite-forming element, and from a biological point of view, the excess of manganese is not reported to be toxic in cardiovascular system [6].…”

Section: Introductionmentioning

confidence: 99%

“…prepared alloys containing from 20 to 35 wt.% manganese by blending, compaction and sintering from elemental Fe and Mn powders. After several rolling-resintering cycles, the samples possessed an austenite structure and exhibited mechanical properties comparable to those of 316L stainless steel [4,5]. The corrosion rates of samples in a modified Hank's solution were determined by the use of an immersion method.…”

Section: Introductionmentioning

confidence: 99%

Dimensional Changes, Microstructure, Microhardness Distributions And Corrosion Properties Of Iron And Iron-Manganese Sintered Materials

Kupková¹,

Hrubovčáková²,

Zeleňák³

et al. 2015

Archives of Metallurgy and Materials

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ZMIANY WYMIAROWE, MIKROSTRUKTURA, ROZKŁAD MIKROTWARDOŚCI I WŁASNOŚCI KOROZYJNE SPIEKANYCH MATERIAŁÓW ŻELAZO ORAZ ŻELAZO-MANGANIron samples and Fe-Mn alloys with Mn content of 25 wt.% and 30 wt.% were prepared by blending, compressing and sintering with the aim to study their dimensional changes, microstructure, microhardness distribution and primarily the electrochemical corrosion behaviour in a simulated body environment.The light microscopy (LM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and microhardness measurements revealed a microheterogeneous multiphase structure of sintered Fe-Mn samples. The potentiodynamic tests have demonstrated that the corrosion rates of such Fe-Mn alloys immersed in Hank's solution were higher than those for a pure iron, and also higher than the rates reported for homogeneous Fe-Mn alloys.Keywords: powder metallurgy, iron, manganese, corrosion behaviour, dimensional changes, microhardnessPróbki żelazne oraz stopy Fe-Mn, zawierające 25 i 30% mas. Mn, przeznaczone na biomateriały, zostały przygotowane na drodze mielenia, prasowania oraz spiekania w celu zbadania ich zmian wymiarowych, mikrostruktury, rozkładu mikrotwardości oraz odporności korozyjnej w skumulowanych w warunkach laboratoryjnych, panujących w ciele człowieka. Badania z wykorzystaniem mikroskopii optycznej i skaningowej, wraz z EDX oraz pomiary mikrotwardości ujawniły mikroniejednorodność wielofazowej struktury spiekanych stopów Fe-Mn. Testy potentiometryczne wykazały, że współczynniki korozji spieków Fe-Mn były wyższe niż spieków wykonanych z czystego żelaza oraz z jednorodnych stopów Fe-Mn.

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Developments in metallic biodegradable stents☆

Cited by 518 publications

References 40 publications

Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals

Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals

Laser surface structuring of AZ31 Mg alloy for controlled wettability

Dimensional Changes, Microstructure, Microhardness Distributions And Corrosion Properties Of Iron And Iron-Manganese Sintered Materials

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