Developments in Gastroesophageal Reflux Disease over the Last 40 Years
Nimish Vakil
Abstract:Background: The last 40 years have seen a remarkable change in our understanding of reflux disease. Summary: These changes encompass disease definition and impact, pathophysiology, diagnostic testing, regulatory oversight of clinical trials, pharmacotherapy, endoscopic, and surgical treatment. We have also seen a number of promising therapies fail. Key Messages: The future holds the promise of further advances. Adaptive artificial intelligence will take over diagnostics in manometry and pH impedance testing an… Show more
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