Developmentally regulated expression of three slow isoforms of myosin heavy chain: Diversity among the first fibers to form in avian muscle

Page, Stella O.; Miller, Jeffrey B.; DiMario, Joseph X.; Hager, Eric; Moser, Arthur H.; Stockdale, Frank E.

doi:10.1016/0012-1606(92)90053-j

Cited by 52 publications

(47 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During primary myogenesis, embryonic or primary myoblasts differentiate to form primary muscle fibers in the absence of functional innervation. A subset of these muscle fibers expresses the slow MyHC2 gene as they first form, independently of innervation (Page et al, 1992). A subset of myotubes in vitro formed from embryonic myoblasts recapitulates this in vivo pattern of expression without innervation (Miller and Stockdale, 1986).…”

Section: Introductionmentioning

confidence: 90%

“…In avian species, the pectoralis major muscle consists of muscle fibers expressing exclusively fast myosin heavy chain (MyHC) genes. The medial adductor muscle consists of fibers all of which express genes encoding both fast MyHCs and slow MyHC2 (Page et al, 1992). Expression of the slow MyHC2 gene characterizes the definitive slow muscle fiber phenotype (Kennedy et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

Jordan

Jiang

et al. 2004

Journal of Cell Science

View full text Add to dashboard Cite

Skeletal muscle fiber type is regulated by innervation-induced cell signaling including calcium release mechanisms that lead to transcriptional activation of fiber type-specific genes. Avian fast pectoralis major (PM) and slow medial adductor (MA) muscles differentially control expression of the slow myosin heavy chain 2 (slow MyHC2) gene. We report here that slow MyHC2 gene expression in fast PM muscle fibers is repressed by endogenous activity of the ryanodine receptor 1 (RyR1). Inhibition of RyR1 with ryanodine led to expression of the slow MyHC2 gene in innervated PM muscle fibers in vitro. Administration of ryanodine to innervated PM muscle fibers also decreased protein kinase C (PKC) activity, the reduction of which is necessary for slow MyHC2 gene expression in both PM and MA muscle fibers. Furthermore, RyR1 inhibition increased slow MyHC2 promoter activity in innervated PM muscle fibers and enhanced transcriptional activities of nuclear factor of activated T cells (NFAT) and myocyte enhancer factor 2 (MEF2), as well as their interactions with their respective binding sites of the slow MyHC2 promoter. These results indicate that RyR1 activity in innervated fast PM muscle fibers contributes to the cell type-specific repression of slow muscle specific genes.

show abstract

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

Jordan

Jiang

et al. 2004

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…Thus, the medial muscle that we have designated 'fast' to fit with zebrafish nomenclature, may actually have a slow contractile rate. In amniotes, all early fibres express some slow MyHC gene, regardless of their later fate (Page et al, 1992). In zebrafish, the medial myotome differentiates into EB165-reactive fast muscle (Blagden et al, 1997).…”

Section: Muscle Fibre Types In Xenopus Developmentmentioning

confidence: 99%

Hedgehog regulation of superficial slow muscle fibres inXenopusand the evolution of tetrapod trunk myogenesis

et al. 2004

View full text Add to dashboard Cite

In tetrapod phylogeny, the dramatic modifications of the trunk have received less attention than the more obvious evolution of limbs. In somites,several waves of muscle precursors are induced by signals from nearby tissues. In both amniotes and fish, the earliest myogenesis requires secreted signals from the ventral midline carried by Hedgehog (Hh) proteins. To determine if this similarity represents evolutionary homology, we have examined myogenesis in Xenopus laevis, the major species from which insight into vertebrate mesoderm patterning has been derived. Xenopus embryos form two distinct kinds of muscle cells analogous to the superficial slow and medial fast muscle fibres of zebrafish. As in zebrafish, Hh signalling is required for XMyf5 expression and generation of a first wave of early superficial slow muscle fibres in tail somites. Thus, Hh-dependent adaxial myogenesis is the likely ancestral condition of teleosts, amphibia and amniotes. Our evidence suggests that midline-derived cells migrate to the lateral somite surface and generate superficial slow muscle. This cell re-orientation contributes to the apparent rotation of Xenopussomites. Xenopus myogenesis in the trunk differs from that in the tail. In the trunk, the first wave of superficial slow fibres is missing,suggesting that significant adaptation of the ancestral myogenic programme occurred during tetrapod trunk evolution. Although notochord is required for early medial XMyf5 expression, Hh signalling fails to drive these cells to slow myogenesis. Later, both trunk and tail somites develop a second wave of Hh-independent slow fibres. These fibres probably derive from an outer cell layer expressing the myogenic determination genes XMyf5, XMyoD and Pax3 in a pattern reminiscent of amniote dermomyotome. Thus, Xenopus somites have characteristics in common with both fish and amniotes that shed light on the evolution of somite differentiation. We propose a model for the evolutionary adaptation of myogenesis in the transition from fish to tetrapod trunk.

show abstract

“…Nearly all avian muscle fibers express a fast myosin heavy chain (MyHC) gene(s). Phenotypic variation in fiber types is largely defined by expression of slow MyHC genes, particularly the slow MyHC2 gene, in some of the muscle fibers (Page et al, 1992). Examples of muscles with these distinct phenotypes include the exclusively fast fiber pectoralis major (PM) and the medial adductor (MA), which uniformly contains fibers that express both fast MyHC genes and the slow MyHC2 gene.…”

Section: Introductionmentioning

confidence: 99%

Regulation of skeletal muscle fiber type and slow myosin heavy chain 2 gene expression by inositol trisphosphate receptor 1

Jordan

Jiang

et al. 2005

Journal of Cell Science

View full text Add to dashboard Cite

Innervation-dependent signaling cascades that control activation of downstream transcription factors regulate expression of skeletal muscle fiber type-specific genes. Many of the innervation-regulated signaling cascades in skeletal muscle are dependent on intracellular calcium and the mechanisms by which calcium is released from the sarcoplasmic reticulum (SR). We report that the inositol trisphosphate receptor 1 (IP3R1), responsible for calcium release from the SR as a slow wave, was more abundant in fast contracting compared to slow contracting avian muscle fibers. Furthermore, inhibition of IP3R1 activity by 2-aminoethoxydiphenylborate (2-APB) and xestospongin D induced a fiber type transition and expression of the slow myosin heavy chain 2 (slow MyHC2) gene in innervated fast muscle fibers. Activation of the slow MyHC2 promoter by IP3R1 inhibition was accompanied by a reduction in protein kinase C activity. In addition, inhibition of IP3R1 activity resulted in a reduction of nuclear factor of activated T cells (NFAT)-dependent transcription and nuclear localization, indicating that IP3R1 activity regulated NFAT transcription factor activity in skeletal muscle fibers. Myocyte enhancer factor 2 (MEF2)-dependent transcriptional activity was increased by innervation, but unaffected by IP3R1 activity. The results indicate that IP3R1 activity regulates muscle fiber type-specific gene expression in innervated muscle fibers.

show abstract

Developmentally regulated expression of three slow isoforms of myosin heavy chain: Diversity among the first fibers to form in avian muscle

Cited by 52 publications

References 36 publications

Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

Hedgehog regulation of superficial slow muscle fibres inXenopusand the evolution of tetrapod trunk myogenesis

Regulation of skeletal muscle fiber type and slow myosin heavy chain 2 gene expression by inositol trisphosphate receptor 1

Contact Info

Product

Resources

About