Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats

Kesby, James P.; Cui, Xiaoying; O’Loan, Joss; McGrath, John; Burne, Thomas H. J.; Eyles, Darryl W.

doi:10.1007/s00213-009-1717-y

Cited by 111 publications

(116 citation statements)

References 68 publications

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“…were hyper-explorative on the hole-board test [40]. Adult DVD deficient rats are more active than controls in novel environments [47,48], show an increased psychomimetic-induced hyperlocomotion and an enhanced startle response after MK-801 injection [49,50]. This suggests that the absence of vitamin D may lead to alterations in similar neural circuits in both the developing and adult brain.…”

Section: Hot Plate Testmentioning

confidence: 99%

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Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

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119

110

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Epidemiological evidence suggests that low levels of vitamin D may predispose people to develop depression and cognitive impairment. While rodent studies have demonstrated that prenatal vitamin D deficiency is associated with altered brain development, there is a lack of research examining adult vitamin D (AVD) deficiency.The aim of this study was to examine the impact of AVD deficiency on behaviour and brain function in the mouse. Ten-week old male C57BL/6J and BALB/c mice were fed a control or vitamin D deficient diet for 10 weeks prior to, and during behavioural testing. We assessed a broad range of behavioural domains, excitatory and inhibitory neurotransmission in brain tissue, and, in separate groups of mice, locomotor response to D-amphetamine and MK-801. Overall, AVD deficiency resulted in hyperlocomotion in a novel open field and reduced GAD65/67 levels in brain tissue. AVD-deficient BALB/c mice had altered behaviour on the elevated plus maze, altered responses to heat, sound and shock, and decreased levels of glutamate and glutamine, and increased levels of GABA and glycine. By contrast C57BL/6 mice had a more subtle phenotype with no further behavioural changes but significant elevations in serine, homovanillic acid and 5-hydroxyindoleacetic acid.Although the behavioural phenotype of AVD did not seem to model a specific disorder, the overall reduction in GAD65/67 levels associated with AVD deficiency may be relevant to a number of neuropsychiatric conditions. This is the first study to show an association between AVD deficiency and prominent changes in behaviour and brain neurochemistry in the mouse.3

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Section: Hot Plate Testmentioning

confidence: 99%

“…For example, two prominent features include deficits in PPI [51] and enhanced locomotor response to amphetamine [49]. These features are both based on alterations in dopamine metabolism, with the dopaminergic system being strongly implicated in the development of schizophrenia [52].…”

Section: Hot Plate Testmentioning

confidence: 99%

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

Self Cite

119

110

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“…The hyperlocomotion induced by amphetamine was observed in adult but not juvenile animals [19]. Furthermore, this amphetamine-induced hyperlocomotion was more pronounced in female Sprague Dawley rats at postnatal-day (PD) 70 when compared to males [19]. Although the MK-801 induced effect was apparent in males at this age [14,18], it was not observed at an equivalent level in females until PD 140 [17].…”

Section: Hyperlocomotionmentioning

confidence: 95%

“…Interestingly, the effects of both MK-801 and amphetamine can be dissociated according to age and sex of the animals. The hyperlocomotion induced by amphetamine was observed in adult but not juvenile animals [19]. Furthermore, this amphetamine-induced hyperlocomotion was more pronounced in female Sprague Dawley rats at postnatal-day (PD) 70 when compared to males [19].…”

Section: Hyperlocomotionmentioning

confidence: 98%

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The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem

Eyles

McGrath

2016

Current Opinion in Behavioral Sciences

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Vitamin D deficiency has been proposed as an environmental risk factor for several neurological disorders. To investigate the biological plausibility of this risk factor, vitamin D (DVD) deficiency rodent models have been used to examine the impact of DVD deficiency on neurobiology and behaviour. The majority of these studies have taken a developmental stance and examined the impact of vitamin D deficiency during gestation on the adult behaviour of the offspring. In the rat, the most constant behavioural phenotypes include hyperlocomotion in response to novelty, psychostimulant sensitively, impulsivity, and augmented motivation. However, in the mouse increased exploratory behaviour and

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Neonatal Vitamin D Status and Risk of Schizophrenia

McGrath¹,

Eyles²,

Pedersen³

et al. 2010

Arch Gen Psychiatry

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313

124

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Both low and high concentrations of neonatal vitamin D are associated with increased risk of schizophrenia, and it is feasible that this exposure could contribute to a sizeable proportion of cases in Denmark. In light of the substantial public health implications of this finding, there is an urgent need to further explore the effect of vitamin D status on brain development and later mental health.

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Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats

Abstract: Taken together, this suggests an alteration in the development of the dopamine system and on dopamine-mediated behaviors in female DVD-deficient rats, and this may be relevant to the underlying neurobiology of schizophrenia.

Cited by 111 publications

References 68 publications

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

The impact of vitamin D deficiency on behaviour and brain function in rodents

Neonatal Vitamin D Status and Risk of Schizophrenia

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