Developmental venous anomalies in patients with multiple sclerosis: is that a coincidence or an ancillary finding?

Grazzini, Irene; Calchetti, Benedetta; Cuneo, Gian Luca

doi:10.1007/s10072-020-04840-5

Cited by 4 publications

(7 citation statements)

References 47 publications

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“…The increased cross-sectional area of the sagittal sinus in people with MS was reported in a study by Bateman et al [22]. Grazzini et al [23] observed that the developmental venous anomalies (DVAs) in patients with MS are higher than in healthy individuals. In the current study, it was observed that the compliance and distensibility of the IJV are higher in the healthy group.…”

Section: Discussionmentioning

confidence: 82%

“…An increased CSA of the sagittal sinus in people with MS was reported by Bateman et al [ 22 ]. Grazzini et al [ 23 ] observed that developmental venous anomalies in patients with MS were higher than in healthy individuals. In the current study, the compliance and distensibility of the IJV were higher in the healthy group, and significantly higher IJV pressure was observed in patients with MS compared to healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

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Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

et al. 2023

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Investigations on the hemodynamic changes of the venous system of patients with multiple sclerosis (MS) have contradictory results. In this study, the biomechanical parameters of the internal Jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals. Methods: B-mode and Doppler sequential ultrasound images of 64 IJV and CCA of women including 22 healthy individuals, 22 RRMS (Relapsing-Remitting Multiple Sclerosis) patients, and 20 PPMS (Primary-Progressive Multiple Sclerosis) patients were recorded and processed. Biomechanical parameters of the IJV and the CCA walls were extracted and calculated in three cardiac cycles. Results:The maximum and the minimum pressures (IJV) were 31% and 19% in RRMS patients and 39% and 24% in PPMS patients more than healthy subjects. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher compared to healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients were 70% and 75% and compliance were 40% and 59% lower compared to healthy subjects. The maximum intima-media thicknesses (CCA) were 38% and 24% and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients compared to healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients were17% and 31%, and radial elastic moduli were 47% and 9% higher compared with healthy individuals. Conclusion:It is concluded that there are significant differences between some physical and biomechanical parameters of CCA and IJV in MS patients and healthy individuals.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

et al. 2023

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“…The implementation of novel MRI techniques in recent years has led to an increased detection rate of DVA as an incidental finding in the normal population (2.6–13.3%) ( 12 , 13 , 15 ). In studies on MS patients, higher DVA rates of (7.6–14.3%) have been described ( 14 , 16 ). This raised the speculation that DVA might be found at an increased rate in MS in line with other data suggesting venous involvement in this disease ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, studies in MS patients have described a relatively variable frequency of DVA. Some publications have reported rates of 7.6–14.3% ( 14 , 16 ), whereas other studies indicated even higher frequencies of 26.9% and 29.5% ( 15 , 17 ). Another recent study showed that the presence of DVA did not significantly differ between the MS and control groups ( 18 ).…”

Section: Introductionmentioning

confidence: 97%

“…Accordingly, previous MRI studies indicated a relatively low incidence of DVA in the normal population of ~1–3% ( 9 – 11 ). The introduction of new MRI techniques in recent years, first at 1.5T and later at 3T, has led to an increased detection rate of DVA as an incidental finding in the normal population (2.6–13.3%) ( 12 – 16 ). Interestingly, studies in MS patients have described a relatively variable frequency of DVA.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

et al. 2022

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ObjectivesThere is evidence of involvement of the venous system in multiple sclerosis (MS). If this bears also an association with the frequency and extent of developmental venous anomalies (DVA) still has to be determined. We therefore investigated this in patients with different phenotypes of MS and in comparison, to a control population.MethodsWe analyzed the contrast-enhanced T1-weighted MR scans of 431 patients (clinically isolated syndrome—CIS, n = 108; MS, n = 323) and of 162 control individuals for the presence of a DVA. We also measured the size of the DVA and draining vein and compared the DVA frequency between MS phenotypes.ResultsA DVA was found in 38 (8.8 %) of patients with CIS or MS and in 11 (6.8%) controls (p = 0.4). DVA frequency was highest in CIS (14.8%) and lowest in progressive MS (4.0%). The mean cranio-caudal and axial extension of the DVA was significantly lower in MS patients than controls (p < 0.05).ConclusionsThe frequency of DVA in MS patients is comparable to that in controls. Whether DVA size and appearance may change over time will have to be investigated in a longitudinal manner and with larger sample size.

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Tumefactive Demyelinating Lesion Around a Developmental Venous Anomaly

et al. 2023

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Developmental venous anomalies in patients with multiple sclerosis: is that a coincidence or an ancillary finding?

Cited by 4 publications

References 47 publications

Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

Tumefactive Demyelinating Lesion Around a Developmental Venous Anomaly

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