Developmental Venous Anomalies are More Common in Patients with Multiple Sclerosis and Clinically Isolated Syndrome

Kruczek, Patrick; Bellenberg, Barbara; Lutz, Theodor; Schneider, Ruth; Ahlborn, Christian; Gold, Ralf; Köster, O.; Lukas, Carsten

doi:10.1007/s00062-019-00869-y

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Moreover, there is agreement with another study with a smaller MS group, where DVAs were more likely (not statistically significant) to be detected in CIS. Remarkably in this study is the much higher number of DVA in the MS group (26.9 vs. 8.8% in our study) ( 17 ). Similarly, high numbers are found in another study by Halicioglu et al with about 105 subjects in both groups and with a probability on DVA of 29.5% in MS and 13.3% in the control group (vascular headache without MS like lesions) ( 15 ).…”

Section: Discussionsupporting

confidence: 43%

“…Interestingly, studies in MS patients have described a relatively variable frequency of DVA. Some publications have reported rates of 7.6–14.3% ( 14 , 16 ), whereas other studies indicated even higher frequencies of 26.9% and 29.5% ( 15 , 17 ). Another recent study showed that the presence of DVA did not significantly differ between the MS and control groups ( 18 ).…”

Section: Introductionmentioning

confidence: 96%

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Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

et al. 2022

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ObjectivesThere is evidence of involvement of the venous system in multiple sclerosis (MS). If this bears also an association with the frequency and extent of developmental venous anomalies (DVA) still has to be determined. We therefore investigated this in patients with different phenotypes of MS and in comparison, to a control population.MethodsWe analyzed the contrast-enhanced T1-weighted MR scans of 431 patients (clinically isolated syndrome—CIS, n = 108; MS, n = 323) and of 162 control individuals for the presence of a DVA. We also measured the size of the DVA and draining vein and compared the DVA frequency between MS phenotypes.ResultsA DVA was found in 38 (8.8 %) of patients with CIS or MS and in 11 (6.8%) controls (p = 0.4). DVA frequency was highest in CIS (14.8%) and lowest in progressive MS (4.0%). The mean cranio-caudal and axial extension of the DVA was significantly lower in MS patients than controls (p < 0.05).ConclusionsThe frequency of DVA in MS patients is comparable to that in controls. Whether DVA size and appearance may change over time will have to be investigated in a longitudinal manner and with larger sample size.

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Section: Discussionsupporting

confidence: 43%

Section: Introductionmentioning

confidence: 96%

Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

et al. 2022

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“…A very recent study showed nearly 30% of MS patients showed DVAs compared to a control group of headache patients with only 14% of cases (119). More recently using post-contrast T1 weighted imaging and FLAIR, Kruczek et al confirmed that DVAs are more common in CIS and earlyonset MS groups compared to controls, however, prevalence of DVA was not related to other imaging markers, or conversion from CIS to clinically definite MS (120). They found roughly 29% of lesions were DVAs and 21/25 cases had at least one DVA.…”

Section: Developmental Venous Anomalies (Dvas)mentioning

confidence: 99%

“…They found roughly 29% of lesions were DVAs and 21/25 cases had at least one DVA. Nevertheless, the authors note the lack of sensitivity of the sequences they used and recommended the use of other sequences such as SWI (120).…”

Section: Developmental Venous Anomalies (Dvas)mentioning

confidence: 99%

An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis

Haacke

Sethi

et al. 2021

Front. Neurol.

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The etiology of multiple sclerosis (MS) is currently understood to be autoimmune. However, there is a long history and growing evidence for disrupted vasculature and flow within the disease pathology. A broad review of the literature related to vascular effects in MS revealed a suggestive role for abnormal flow in the medullary vein system. Evidence for venous involvement in multiple sclerosis dates back to the early pathological work by Charcot and Bourneville, in the mid-nineteenth century. Pioneering work by Adams in the 1980s demonstrated vasculitis within the walls of veins and venules proximal to active MS lesions. And more recently, magnetic resonance imaging (MRI) has been used to show manifestations of the central vein as a precursor to the development of new MS lesions, and high-resolution MRI using Ferumoxytol has been used to reveal the microvasculature that has previously only been demonstrated in cadaver brains. Both approaches may shed new light into the structural changes occurring in MS lesions. The material covered in this review shows that multiple pathophysiological events may occur sequentially, in parallel, or in a vicious circle which include: endothelial damage, venous collagenosis and fibrin deposition, loss of vessel compliance, venous hypertension, perfusion reduction followed by ischemia, medullary vein dilation and local vascular remodeling. We come to the conclusion that a potential source of MS lesions is due to locally disrupted flow which in turn leads to remodeling of the medullary veins followed by endothelial damage with the subsequent escape of glial cells, cytokines, etc. These ultimately lead to the cascade of inflammatory and demyelinating events which ensue in the course of the disease.

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Tumefactive Demyelinating Lesion Around a Developmental Venous Anomaly

et al. 2023

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Developmental Venous Anomalies are More Common in Patients with Multiple Sclerosis and Clinically Isolated Syndrome

Cited by 4 publications

References 32 publications

Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis

Tumefactive Demyelinating Lesion Around a Developmental Venous Anomaly

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