Developmental Vascularization, Neurogenesis, Myelination, and Astrogliogenesis

Harry, G. Jean; Pont-Lezica, Lorena

doi:10.1007/978-1-4939-1429-6_8

Cited by 2 publications

(3 citation statements)

References 197 publications

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“…Microglia play regulatory and supportive roles for the other CNS cell types, including astrocytes, oligodendrocyte lineage cells, and neurons, and they also contribute to modulating physical brain structures, including blood vessels and the blood-brain barrier (BBB) (48,60). Specifically, microglia support astrocyte differentiation, maturation, and function, including astrocytic control of (synaptic) glutamate and astrocytic reactivity during pathology (28). Furthermore, microglia can facilitate oligodendrocyte progenitor cell differentiation and oligodendrocyte myelination, phagocytosis of myelin debris, and myelin refinement (28,48).…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, microglia support astrocyte differentiation, maturation, and function, including astrocytic control of (synaptic) glutamate and astrocytic reactivity during pathology (28). Furthermore, microglia can facilitate oligodendrocyte progenitor cell differentiation and oligodendrocyte myelination, phagocytosis of myelin debris, and myelin refinement (28,48). With regard to neurons, microglia also contribute to neurogenesis and alterations of neuron numbers and produce factors that modulate neuronal migration and survival (59).…”

Section: Introductionmentioning

confidence: 99%

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Microglial Transcriptional Signatures in the Central Nervous System: Toward A Future of Unraveling Their Function in Health and Disease

Vecchiarelli

Tremblay

2023

Annu. Rev. Genet.

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Microglia, the resident immune cells of the central nervous system (CNS), are primarily derived from the embryonic yolk sac and make their way to the CNS during early development. They play key physiological and immunological roles across the life span, throughout health, injury, and disease. Recent transcriptomic studies have identified gene transcript signatures expressed by microglia that may provide the foundation for unprecedented insights into their functions. Microglial gene expression signatures can help distinguish them from macrophage cell types to a reasonable degree of certainty, depending on the context. Microglial expression patterns further suggest a heterogeneous population comprised of many states that vary according to the spatiotemporal context. Microglial diversity is most pronounced during development, when extensive CNS remodeling takes place, and following disease or injury. A next step of importance for the field will be to identify the functional roles performed by these various microglial states, with the perspective of targeting them therapeutically. Expected final online publication date for the Annual Review of Genetics, Volume 57 is November 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microglial Transcriptional Signatures in the Central Nervous System: Toward A Future of Unraveling Their Function in Health and Disease

Vecchiarelli

Tremblay

2023

Annu. Rev. Genet.

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“…In the nervous system, microglia serve as the resident mononuclear phagocytes that respond to intrinsic and extrinsic factors, leading to changes in cell function and responsiveness (for review, Sominsky et al, 2018). In this function microglia play a critical role in multiple processes (Harry and Kraft, 2012;Thion and Garel, 2017) not only with injury but also during CNS development including, neurovascularation (Harry and Pont-Lezica, 2014), neural cell differentiation (Erblich et al, 2011), neural migration (Aarum et al, 2004), and synaptic pruning and sculpting (Schafer et al, 2012). Thus, alterations in the function of these cells can significantly contribute to neurotoxicity during development and across the life-span.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells

Bowen¹,

Childers²,

Perry³

et al. 2020

Chemosphere

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The predominant reliance on bromated flame retardants (BFRs) is diminishing with expanded use of alternative organophosphate flame retardants. However, exposure related issues for susceptible populations, the developing, infirmed, or aged, remain given environmental persistence and home environment detection. In this regard, reports of flame retardant (FR)-related effects on the innate immune system suggest process by which a spectrum of adverse health effects could manifest across the life-span. As representative of the nervous system innate immune system, the current study examined changes in microglia following exposure to representative FRs, pentabromophenol (PBP), tetrabromobisphenol A (2,2',6,6',-tetrabromo-4,4'-isopropylidine diphenol; TBBPA) and triphenyl phosphate (TPP). Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration was altered by PBP; ATP-linked respiration by PBP and TBBPA, and maximum respiration by all three FRs. Basal glycolytic rate was altered by PBP and TBBPA and compensatory glycolysis by all three. Phagocytosis was decreased for PBP and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to

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Developmental Vascularization, Neurogenesis, Myelination, and Astrogliogenesis

Cited by 2 publications

References 197 publications

Microglial Transcriptional Signatures in the Central Nervous System: Toward A Future of Unraveling Their Function in Health and Disease

Microglial Transcriptional Signatures in the Central Nervous System: Toward A Future of Unraveling Their Function in Health and Disease

Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells

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