2011
DOI: 10.1016/j.psyneuen.2010.07.008
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Developmental validation of a point-of-care, salivary α-amylase biosensor

Abstract: The translation of salivary alpha-amylase (sAA) to the ambulatory assessment of stress hinges on the development of technologies capable of speedy and accurate reporting of sAA levels. Here, we describe the developmental validation and usability testing of a point-of-care, colorimetric, sAA biosensor. A disposable test strip allows for streamlined sample collection and a corresponding hand-held reader with integrated analytic capabilities permits rapid analysis and reporting of sAA levels. Bioanalytical valida… Show more

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Cited by 80 publications
(72 citation statements)
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“…In our study, we encountered more failures and inconsistencies as compared to those reported in the literature (15,18). These failures could have been in the methods used to collect the samples.…”
Section: Discussionmentioning
confidence: 64%
“…In our study, we encountered more failures and inconsistencies as compared to those reported in the literature (15,18). These failures could have been in the methods used to collect the samples.…”
Section: Discussionmentioning
confidence: 64%
“…Within the biosensor's linear range (10-230 U/ml), the accuracy (R 2 = .989), the precision established by inter-run measurements of saliva samples taken with the same device (the coefficient of variation < 9%), and measurement repeatability (range À3.1% to +3.1%) of this type of handheld monitor has been found to approach that of more elaborate laboratory-based automated clinical chemistry analysis tools (Olympus America Inc., Center Valley, PA, USA) (Shetty, Zigler, Robles, Elashoff, & Yamaguchi, 2011). Salivary a-amylase was measured from saliva samples collected under the tongue by inserting the reagent test strip directly into the subject's oral cavity.…”
Section: Apparatus and Taskmentioning
confidence: 93%
“…18,19,48,49 These methods use only single-point measurements (vs continuous monitoring) and usually require significant operator input, e.g., manual dipstick testing or downloading and manual processing of collected data on a separate computer.…”
Section: ■ Results and Discussionmentioning
confidence: 99%