Developmental trajectory of transmission speed in the human brain

Blooijs, Dorien van; Boom, Max van den; Aar, Jaap F. van der; Huiskamp, Geertjan; Castegnaro, Giulio; Demuru, Matteo; Zweiphenning, Willemiek; Eijsden, Pieter van; Miller, Kai J.; Leijten, Frans S.S.; Hermes, Dora

doi:10.1038/s41593-023-01272-0

Cited by 21 publications

(22 citation statements)

References 52 publications

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“…We know that aging brings changes in memory, word access, and cognitive alterations as well as changes on MRI, including cell loss, decreasing gray matter, loss of inhibitory connections, faster processing (Barrio‐Hernandez et al, 2023; van Blooijs et al, 2023) and new neuronal connections (pathways) (Cohen, 2005). In addition, there are changes in organelle function (Vardalaki et al, 2022) (such as in ribosome, mitochondria, lysosome, etc.)…”

Section: Proposed Physiologic Stages Erikson's Psychologic Stages Ill...mentioning

confidence: 99%

The importance of age‐specific gene expression

Hall

2023

American J of Med Genetics Pt A

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Section: Proposed Physiologic Stages Erikson's Psychologic Stages Ill...mentioning

confidence: 99%

The importance of age‐specific gene expression

Hall

2023

American J of Med Genetics Pt A

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“…9−12 For instance, ion-selective membranes at the anterior surface of dendrites are an essential medium in the transmission of nerve signals (Figure 1a). Research has demonstrated that the response time to a single-pulse stimulus in the average adult is approximately 25−30 ms. 13 The ultrafast signaling is strongly associated with unique ion selectivity and the nanofluidic channel structure of the membrane. With the above view- points, verifying the sensing capabilities of a hydrogel for K + ions in conjunction with the sensor device, the possible superior performance could lay a foundation for comprehending current crucial issues prevailing in this field.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In nature, hydrogels exist in various forms across different organisms, catering to the requirements of diverse functions based on ion transport of charge control. − For instance, ion-selective membranes at the anterior surface of dendrites are an essential medium in the transmission of nerve signals (Figure a). Research has demonstrated that the response time to a single-pulse stimulus in the average adult is approximately 25–30 ms . The ultrafast signaling is strongly associated with unique ion selectivity and the nanofluidic channel structure of the membrane.…”

Section: Introductionmentioning

confidence: 99%

Engineering Interconnected Nanofluidic Channel in a Hydrogel Supernetwork toward K⁺ Ion Accelerating Transport and Efficient Sensing

Zhu,

Sun,

Cui

et al. 2024

ACS Appl. Mater. Interfaces

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Ion transportation via the mixed mechanisms of hydrogels underpins ultrafast biological signal transmission in nature, and its application to the rapid and sensitive sensing detection of human specific ions is of great interest for the field of medical science. However, current research efforts are still unable to achieve transmission results that are comparable to those of bioelectric signals. Herein, 3D interconnected nanochannels based on poly(pyrrole-co-dopamine)/poly(vinyl alcohol) (P(Py-co-DA)/PVA) supernetwork conductive hydrogels are designed and fabricated as stimuli-responsive structures for K + ions. Distinct from conventional configurations, which exhibit rapid electron transfer and permeability to biosubstrates, interconnected nanofluidic nanochannels collaborated with the P(Py-co-DA) conductive polymer in the supernetwork conductive hydrogel significantly improve conductivity (88.3 mS/ cm), ion transport time (0.1 s), and ion sensitivity (74.6 mV/dec). The faster ion response time is attributed to the synergism of excellent conductivity originating from the P(Py-co-DA) polymer and the electronic effect in the interconnected nanofluidic channels. Furthermore, the supernetwork conductive hydrogel demonstrates K + ion selectivity relative to other cations in biofluids such as Na + , Mg 2+ , and Ca 2+ . The DFT calculation indicates that the small solvation energy and low chemical transfer resistance are the main reasons for the excellent K + ion selectivity. Finite element analysis (FEA) simulations further support these experimental results. Consequently, the P(Py-co-DA)/PVA supernetwork conductive hydrogels enriched with the 3D interconnected nanofluidic channels developed in this work possess excellent sensing of K + ions. This strategy provides great insight into efficient ion sensing in traditional biomedical sensing that has not been explored by previous researchers.

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“…12–14 For example, a recent study that combined CCEPs with tractography observed considerable age-related changes in the transmission speed of cortico-cortical signals. 15…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] For example, a recent study that combined CCEPs with tractography observed considerable age-related changes in the transmission speed of cortico-cortical signals. 15 Emerging evidence suggests that the temporal dynamics of CCEPs may also provide novel insights into the patterns of information flow between and within brain networks. 16,17 At present, these spatiotemporal dynamics of CCEP propagation cortically and subcortically are incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Macroscale traveling waves evoked by single-pulse stimulation of the human brain

Campbell

Davis

Anderson

et al. 2023

Preprint

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Emerging evidence suggests that the temporal dynamics of cortico-cortical evoked potentials (CCEPs) may be used to characterize the patterns of information flow between and within brain networks. At present, however, the spatiotemporal dynamics of CCEP propagation cortically and subcortically are incompletely understood. We hypothesized that CCEPs propagate as an evoked traveling wave emanating from the site of stimulation. To elicit CCEPs, we applied single-pulse stimulation to stereoelectroencephalography (SEEG) electrodes implanted in 21 adult patients with intractable epilepsy. For each robust CCEP, we measured the timing of the maximal descent in evoked local field potentials and broadband high-gamma power (70-150 Hz) envelopes relative to the distance between the recording and stimulation contacts using three different metrics (i.e., Euclidean distance, path length, geodesic distance), representing direct, subcortical, and transcortical propagation, respectively. Many evoked responses to single-pulse electrical stimulation appear to propagate as traveling waves (~17-30%), even in the sparsely sampled, three-dimensional SEEG space. These results provide new insights into the spatiotemporal dynamics of CCEP propagation.

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Developmental trajectory of transmission speed in the human brain

Cited by 21 publications

References 52 publications

The importance of age‐specific gene expression

The importance of age‐specific gene expression

Engineering Interconnected Nanofluidic Channel in a Hydrogel Supernetwork toward K⁺ Ion Accelerating Transport and Efficient Sensing

Macroscale traveling waves evoked by single-pulse stimulation of the human brain

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Developmental trajectory of transmission speed in the human brain

Cited by 21 publications

References 52 publications

The importance of age‐specific gene expression

The importance of age‐specific gene expression

Engineering Interconnected Nanofluidic Channel in a Hydrogel Supernetwork toward K+ Ion Accelerating Transport and Efficient Sensing

Macroscale traveling waves evoked by single-pulse stimulation of the human brain

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Product

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Engineering Interconnected Nanofluidic Channel in a Hydrogel Supernetwork toward K⁺ Ion Accelerating Transport and Efficient Sensing