Developmental trajectories during adolescence in males and females: A cross-species understanding of underlying brain changes

Brenhouse, Heather C.; Andersen, Susan

doi:10.1016/j.neubiorev.2011.04.013

Cited by 308 publications

(270 citation statements)

References 263 publications

(339 reference statements)

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“…Adolescence is a period in which the brain undergoes dramatic transitions and re-organization (Brenhouse and Andersen, 2011). For example, adolescents tend to overexpress various neuroreceptors (eg, dopaminergic, adrenergic, serotonergic) followed by pruning to adult levels (an inverted U-shape curve of development).…”

Section: Discussionmentioning

confidence: 99%

Olanzapine Sensitization and Clozapine Tolerance: From Adolescence to Adulthood in the Conditioned Avoidance Response Model

Qiao

2012

Neuropsychopharmacol

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Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague-Dawley rats (approximate postnatal days (BP) 43-47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 mg/kg, sc) daily for 5 consecutive days in the CAR model. They were then tested for the expression of OLZ sensitization or CLZ tolerance either in adolescence (BP 50) or after they matured into adults (BP 76 and 92) in a challenge test during which all rats were injected with either a lower dose of OLZ (0.5 mg/kg) or CLZ (5.0 mg/kg). When tested in adolescence, rats previously treated with OLZ showed a stronger inhibition of CAR than those previously treated with vehicle (ie, sensitization). In contrast, rats previously treated with CLZ showed a weaker inhibition of CAR than those previously treated with vehicle (ie, tolerance). When tested in adulthood, the OLZ sensitization was still detectable at both time points (BP 76 and 92), whereas the CLZ tolerance was only detectable on BP 76, and only manifested in the intertrial crossing. Performance in the prepulse inhibition and fear-induced 22 kHz ultrasonic vocalizations in adulthood were not altered by adolescence drug treatment. Collectively, these findings suggest that atypical antipsychotic treatment during adolescence can induce a long-term specific alteration in antipsychotic effect that persists into adulthood despite the brain maturation. As antipsychotic drugs are being increasingly used in children and adolescents in the past two decades, findings from this study are important for understanding the impacts of adolescent antipsychotic treatment on the brain and behavioral developments. This work also has implications for clinical practice involving adolescence antipsychotic treatments in terms of drug choice, drug dose, and schedule.

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Section: Discussionmentioning

confidence: 99%

Olanzapine Sensitization and Clozapine Tolerance: From Adolescence to Adulthood in the Conditioned Avoidance Response Model

Qiao

2012

Neuropsychopharmacol

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“…Other developmental processes, such as synaptogenesis, synaptic refinement, myelination, and neurogenesis also start in fetal life, but continue after birth, in some cases well into adult life. These cellular events set the foundation for higher-order processes of brain development (Brenhouse and Andersen, 2011a;Casey et al, 2008;Crone and Dahl, 2012;Giedd and Rapoport, 2010;Tau and Peterson, 2010). Here we provide a brief overview of the key postnatal maturational events driving brain development.…”

Section: Box 2 Brain Developmentmentioning

confidence: 99%

“…The process involves the differentiation of proliferating glia-like cells into neuroblasts and ultimately neurons through developmental milestones that resemble those occurred during embryonic neurogenesis (Ming and Song, 2011). Of note, these processes of neuronal development take place according to regional patterns (heterochronicity), which are typically seen earlier in females than males (Brenhouse and Andersen, 2011a). Synaptogenesis, synaptic refinement, and myelination all occur in a stereotypical posterior-to-anterior direction, first seen in the sensory and motor cortical areas, then in association cortical areas and the corpus callosum, and eventually in the frontal lobe (Levitt, 2003;Tau and Peterson, 2010).…”

Section: Box 2 Brain Developmentmentioning

confidence: 99%

Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Danese

Lewis

2016

Neuropsychopharmacol

293

191

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The brain and the immune system are not fully formed at birth, but rather continue to mature in response to the postnatal environment. The two-way interaction between the brain and the immune system makes it possible for childhood psychosocial stressors to affect immune system development, which in turn can affect brain development and its long-term functioning. Drawing from experimental animal models and observational human studies, we propose that the psychoneuroimmunology of early-life stress can offer an innovative framework to understand and treat psychopathology linked to childhood trauma. Earlylife stress predicts later inflammation, and there are striking analogies between the neurobiological correlates of early-life stress and of inflammation. Furthermore, there are overlapping trans-diagnostic patterns of association of childhood trauma and inflammation with clinical outcomes. These findings suggest new strategies to remediate the effect of childhood trauma before the onset of clinical symptoms, such as anti-inflammatory interventions and potentiation of adaptive immunity. Similar strategies might be used to ameliorate the unfavorable treatment response described in psychiatric patients with a history of childhood trauma.

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“…The stressors were administered during the light phase on 7 days across the period spanning postnatal days 28e42, a transitional period culminating in puberty onset and associated with diverse behavioral and brain maturational processes, notably in the prefrontal cortex (Brenhouse and Andersen, 2011;Korenbrot et al, 1977;Spear, 2000). The protocol started with an exposure to an open field on P28 (5 min), after which subjects experienced repeated stress exposures (25 min) as described next, to an elevated platform or predator odor, either exclusively (P34, P36, P42) or one after another (P28e30, P40) in a pre-determined variable order.…”

Section: Peripubertal Stressmentioning

confidence: 99%

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

Poirier

Imamura

Zanoletti

et al. 2014

Journal of Psychiatric Research

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a b s t r a c tAdolescence is increasingly recognized as a critical period for the development of the social system, through the maturation of social competences and of their underlying neural circuitries. The present study sought to test the utility of resveratrol, a dietary phenol recently reported to have mood lifting properties, in modulating social interaction that is deficient following early life adversity. The main aims were to 1) pharmacologically restore normative social investigation levels dampened by peripubertal stress in rats and 2) identify neural pathways engaged by this pharmacological approach. Following peripubertal (P28e42) stress consisting of unpredictable exposures to fearful experiences, at adulthood the subjects' propensity for social exploration was examined in the three-chamber apparatus, comparing time invested in social or non-social investigation. Administered intraperitoneally 30 min before testing, resveratrol (20 mg/kg) normalized the peripubertal stress-induced social investigation deficit seen in the vehicle group, selectively altering juvenile but not object exploration. Examination of prefrontal cortex subregion protein samples following acute resveratrol treatment in a separate cohort revealed that while monoamine oxidase A (MAOA) enzymatic activity remained unaltered, nuclear AKT activation was selectively increased in the infralimbic cortex, but not in the prelimbic or anterior cingulate cortex. In contrast, androgen receptor nuclear localization was increased in the prelimbic cortex, but not in the infralimbic or anterior cingulate cortex. This demonstration that social contact deficits are reversed by resveratrol administration emphasizes a prosocial role for this dietary phenol, and evokes the possibility of developing new treatments for social dysfunctions.

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Developmental trajectories during adolescence in males and females: A cross-species understanding of underlying brain changes

Cited by 308 publications

References 263 publications

Olanzapine Sensitization and Clozapine Tolerance: From Adolescence to Adulthood in the Conditioned Avoidance Response Model

Olanzapine Sensitization and Clozapine Tolerance: From Adolescence to Adulthood in the Conditioned Avoidance Response Model

Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

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