Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

Mu, Xueyan; LeBlanc, Gerald A.

doi:10.1016/s0016-6480(02)00518-x

Cited by 62 publications

(39 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors have demonstrated that exposure D. magna to 1.15 and 2.30 mg L À1 testosterone significantly reduced the fecundity, had no effect on parental survival but delayed moulting and significantly increased developmental abnormalities in offspring. Developmental abnormalities induced by anti-ecdysteroids, including testosterone, can be associated with suppressed ecdysone levels in embryos and these abnormalities (carapace, antennae to severely developmentally arrested individuals) can be protect by co-exposure to 20-hydroxyecdysone (Mu and LeBlanc, 2002). However, in our study no morphological abnormalities among the offspring or delays in moulting were observed.…”

Section: Article In Presscontrasting

confidence: 72%

“…Some studies indicate that testosterone, which is structurally similar to estrogen, elicits embryo toxicity to daphnids by interfering with ecdysteroid activity (Mu and LeBlanc, 2002). The authors have demonstrated that exposure D. magna to 1.15 and 2.30 mg L À1 testosterone significantly reduced the fecundity, had no effect on parental survival but delayed moulting and significantly increased developmental abnormalities in offspring.…”

Section: Article In Pressmentioning

confidence: 99%

See 1 more Smart Citation

Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna

Barbosa

Nogueira

Soares

2008

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

a b s t r a c tSteroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedione was assessed for the freshwater cladoceran Daphnia magna. Acute toxicity tests showed that 6.20 mg L À1 of testosterone, the highest concentration tested, did not have effect on the daphnids, whereas 4-hydroxyandrostenedione had an EC 50 of 4.26 mg L À1 . Chronic toxicity tests were carried out using survival, body length, fecundity, and fertility as endpoints. Long-term testosterone exposure reduced D. magna fecundity and fertility at concentrations ranging from 0.31 to 2.48 mg L À1 . The significant decrease in fecundity was associated with an increase in aborted eggs. Long-term 4-hydroxyandrostenedione exposure at 0.84 mg L À1 increased the mortality of the neonates. The chronic toxicity effects were observed at concentrations higher than the measured environmental concentrations of these compounds. Nevertheless, the reproductive impairment of the daphnids is likely to occur at environmental levels as an ultimate response to long-term exposure.

show abstract

Section: Article In Presscontrasting

confidence: 72%

Section: Article In Pressmentioning

confidence: 99%

Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna

Barbosa

Nogueira

Soares

2008

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

show abstract

“…In Daphnia magna, the effects of testosterone was counteracted by increasing concentrations of 20-hydroxyecdysone, which led to the proposal that vertebrate-type steroids can act as ecdysone antagonists (Mu and LeBlanc 2002). This assumption is however not supported by data obtained with another copepod species and with a cellular bioassay used for the screening of ecdysone agonists and antagonists (Dinan et al 2001b;Hutchinson 2002;Pounds et al 2002).…”

Section: Arthropodsmentioning

confidence: 99%

Steroids in aquatic invertebrates

2007

View full text Add to dashboard Cite

Steroid molecules are present in all invertebrates, and some of them have established hormonal roles: this is the case for ecdysteroids in arthropods and, to a lesser extent, for vertebrate-type steroids in molluscs. Steroids are not only hormones, they may also fulfill many other functions in chemical communication, chemical defense or even digestive physiology. The increasing occurrence of endocrine disruption problems caused by environmental pollutants, which interfere in particular with reproductive physiology of vertebrates but also of invertebrates has made necessary to better understand the endocrine physiology of the latter and the role of steroids in these processes. So many attempts are being made to better understand the endocrine roles of steroids in arthropods and molluscs, and to establish whether they also fulfill similar functions in other invertebrate phyla. At the moment, both the precise identification of these steroids, the determination of their origin (endogenous versus exogenous) and of their mechanism of action are under active investigation. This research takes profit of the development of genome sequencing programs on many invertebrate species, which allow the identification of receptors and/or biosynthetic enzymes, when related to their vertebrate counterparts, but the story is not so simple, as will be exemplified by estrogen receptors of molluscs.

show abstract

“…A 12-week reproduction study with L. stagnalis (great pond snail) demonstrated decreased reproduction at 1 m g/L (Czech et al 2001 ) , and sex development was highly affected at concentrations <0.1 m g/L in a longer study (12 month) performed with M. cornuarietis (ramshorn snail) (Schulte-Oehlmann et al 2004 ) . Twenty-one-day exposure to testosterone has also been observed to reduce the numbers of female D. magna produced (Mu and LeBlanc 2002 ) . Goldfi sh ( C. carassius ) and killifi sh ( O. latipes ) appeared to have greater sensitivity than snails when examining reproduction and sex ratio after 80-and 42-day methyltestosterone exposure, respectively (Fujioka 2002 ;Zerulla et al 2002 ) .…”

Section: Androgensmentioning

confidence: 99%

Human Pharmaceuticals in the Aquatic Environment: A Review of Recent Toxicological Studies and Considerations for Toxicity Testing

Brausch

Connors

Brooks

et al. 2012

Reviews of Environmental Contamination and Toxicology

133

119

View full text Add to dashboard Cite

Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

Cited by 62 publications

References 14 publications

Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna

Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna

Steroids in aquatic invertebrates

Human Pharmaceuticals in the Aquatic Environment: A Review of Recent Toxicological Studies and Considerations for Toxicity Testing

Contact Info

Product

Resources

About