Developmental toxicity of arsenic: a drift from the classical dose–response relationship

Bjørklund, Geir; Tippairote, Torsak; Rahaman, Md. Shiblur; Aaseth, Jan

doi:10.1007/s00204-019-02628-x

Cited by 23 publications

(8 citation statements)

References 78 publications

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“…Our study has confirmed the prolongation of QT interval as a major complication of As exposure 40–42 . Blocking potassium channels by As increases the risk of excessive repolarization delay in phase 3 of the cardiac action potential, causing changes in ventricular action potential duration (APD) 43 . Increased APD is reflected by prolongation of the QT interval, displaying ventricular depolarization and repolarization 44 .…”

Section: Discussionsupporting

confidence: 71%

Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats

et al. 2023

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Chronic arsenic (As) exposure, mainly as a result of drinking contaminated water, is associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and autophagy have been suggested as the molecular etiology of As cardiotoxicity. Melatonin (Mel) is a powerful antioxidant. Mel improves diabetic cardiomyopathy, cardiac remodeling, and heart failure. Following pre-treatment with Mel (10, 20, or 30 mg/kg/day i.p.), rats were orally gavaged with As (15 mg/kg/day) for 28 days. Electrocardiographic findings showed that Mel decreased the As-mediated QT interval prolongation. The effects of As on cardiac levels of glutathione (GSH) and malondialdehyde (MDA) were reversed by Mel pretreatment. Mel also modulated the Sirt1 and Nrf2 expressions promoted by As. Mel down-regulated autophagy markers such as Beclin-1 expression and the LC3-II/I ratio. Moreover, the cardiac expression of cleaved-caspase-3 and Bax/Bcl-2 ratio was decreased by Mel pretreatment. Reduced expression of miR-34a and miR-144 by As were reversed by Mel. The histopathological changes of cardiac injury

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Section: Discussionsupporting

confidence: 71%

Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats

et al. 2023

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“…Depending on exposure levels and circumstances, various health consequences are observed, such as skin rashes and pulmonary and cardiovascular diseases. Children and infants exposed to arsenic frequently develop neuro-developmental and -behavioral disorders [43,44].…”

Section: Table 3 Toxic Hazardsmentioning

confidence: 99%

Reducing disease and death from Artisanal and Small-Scale Mining (ASM) - the urgent need for responsible mining in the context of growing global demand for minerals and metals for climate change mitigation

et al. 2022

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Artisanal and small-scale mining (ASM) takes place under extreme conditions with a lack of occupational health and safety. As the demand for metals is increasing due in part to their extensive use in ‘green technologies’ for climate change mitigation, the negative environmental and occupational consequences of mining practices are disproportionately felt in low- and middle-income countries. The Collegium Ramazzini statement on ASM presents updated information on its neglected health hazards that include multiple toxic hazards, most notably mercury, lead, cyanide, arsenic, cadmium, and cobalt, as well as physical hazards, most notably airborne dust and noise, and the high risk of infectious diseases. These hazards affect both miners and mining communities as working and living spaces are rarely separated. The impact on children and women is often severe, including hazardous exposures during the child-bearing age and pregnancies, and the risk of child labor. We suggest strategies for the mitigation of these hazards and classify those according to primordial, primary, secondary, and tertiary prevention. Further, we identify knowledge gaps and issue recommendations for international, national, and local governments, metal purchasers, and employers are given. With this statement, the Collegium Ramazzini calls for the extension of efforts to minimize all hazards that confront ASM miners and their families.

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“… 3 iAs and its metabolites can cross the placenta, 25 and fetal exposure has been associated with lower birth weight 26 and adverse neurodevelopmental effects. 27 , 28 , 29 …”

Section: Arsenic Sources and Toxicitymentioning

confidence: 99%

Navigating a Two-Way Street: Metal Toxicity and the Human Gut Microbiome

Schmidt¹

2022

Environ Health Perspect

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Developmental toxicity of arsenic: a drift from the classical dose–response relationship

Cited by 23 publications

References 78 publications

Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats

Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats

Reducing disease and death from Artisanal and Small-Scale Mining (ASM) - the urgent need for responsible mining in the context of growing global demand for minerals and metals for climate change mitigation

Navigating a Two-Way Street: Metal Toxicity and the Human Gut Microbiome

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