Developmental toxicity evaluation of unleaded gasoline vapor in the rat

Roberts, Linda G.; White, Russell D.; Bui, Quang Q.; Daughtrey, Wayne C.; Koschier, Francis J.; Rodney, Sara; Schreiner, C A; Steup, David R.; Breglia, R.; Rhoden, R; Schroeder, Raymond E.; Newton, Paul E.

doi:10.1016/s0890-6238(01)00150-2

Cited by 17 publications

(6 citation statements)

References 7 publications

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“…These data extend results from published reproductive and developmental studies on inhaled vapors of gasoline (Roberts et al, 2001;McKee et al, 2000) and gasoline blended with 10% ethanol (E10, Gray et al, 2014) to include neurocognitive tests in offspring exposed in utero to fuel vapors containing substantial concentrations of ethanol. Few deficits were detected in tests of learning, memory and attention.…”

Section: Discussionsupporting

confidence: 77%

“…These studies exposed rats (male and female) to vapors of gasoline (McKee et al, 2000) or gasoline with 10% ethanol (Gray et al, 2014) for 6 h daily, 7 days a week prior to and during mating and found no effects on any reproductive indices including fertility, organ weights, pathology, gestational length and litter size. Additionally, no effects were found on fetal development indices, including body weight, growth, malformations, resorptions and viability in offspring exposed in utero 6 h daily to gasoline VC vapors during gestational days (GD) 6 to 19 (Roberts et al, 2001) or to gasoline and E10 VC vapors during GD 5 to 20 (Roberts et al, 2014) at concentrations up to 20,000 mg/m 3 . No neurodevelopmental evaluations were included in this series of studies.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to vapors of gasoline–ethanol blends causes few cognitive deficits in adult rats

Oshiro

Beasley

McDaniel

et al. 2015

Neurotoxicology and Teratology

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to vapors of gasoline–ethanol blends causes few cognitive deficits in adult rats

Oshiro

Beasley

McDaniel

et al. 2015

Neurotoxicology and Teratology

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“…It has been reported that incorporation of L48Q cTnC significantly increased contractility of cardiomyocytes from healthy and MI hearts without adversely affecting Ca2 + transient properties or relaxation. However, some studies have shown that unleaded gasoline vapors did not produce evidence of developmental toxicity [19].…”

Section: B Discussionmentioning

confidence: 99%

Diesel Oil Vapor Inhalation: Risk Factor for Heart Attack

2014

International Conference on Chemical, Environment &Amp; Biological Sciences (CEBS-2014) Sept. 17-18, 2014 Kuala Lumpur (Malaysi

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The studies show that breathing diesel oil vapor impose serious health damage on body systems.. The main aim of this study was to determine the effects of diesel oil vapor inhalation on serum levels of cardiac troponin in male rats. In our study male Wistar rats were randomly divided into control and groups exposed to diesel oil vapor for 1, 4 or 8h/day of 5 rats in each group. After 8 weeks, blood samples were obtained using cardiac puncture method. Following serum preparation, level of cardiac troponin was measured using immunoassay method. Data were statistically analyzed and compared between groups using ANOVA. The results indicated that serum level of cardiac troponin increased in rats exposed to diesel oil vapor for 4 and 8h/day compared to control rats (P<0.001 and P<0.05, respectively). Our findings show that exposure to diesel vapor for long period of time enhances serum cardiac troponin level which may indicate damage to heart.

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“…2,5,7,8 Several of these articles also reported hematological effects. 2,5,7,8 None of the naphthas 3,4,6,7 or blended gasoline 12,13 has been reported to affect reproductive or developmental parameters when tested at exposure levels that approximated half of the lower explosive limits. Taken together, the effects of the various naphtha streams seem reasonably similar to each other and to blended gasoline.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Assessment of Heavy Straight Run Naphtha in a Repeated Dose/Reproductive Toxicity Screening Test

McKee

Steup

Schreiner³

et al. 2013

Int J Toxicol

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Gasoline blending stocks (naphthas) are comprised of normal, iso-and cycloparaffins and aromatic hydrocarbons with carbon numbers ranging from C4 to C12. Heavy straight run naphtha (HSRN, CAS number 64741-41-9) was selected for toxicity screening because substances of this type contain relatively high levels (28%) of cycloparaffins by comparison to other naphtha streams and the data complement toxicity information on other gasoline blending streams. Rats were exposed by inhalation to wholly vaporized material at levels of approximately 100, 500, or 3000 parts per million (ppm) daily to screen the potential for systemic toxicity, neurotoxicity, reproductive toxicity, and developmental effects to postnatal day 4. All animals survived the treatment period. Principal effects of repeated exposure included increased liver weights in males and females, increased kidney weights in males, and histological changes in the thyroid, secondary to liver enzyme induction. These changes were not considered to be toxicologically meaningful and are not relevant to humans. There were no treatment-related effects in functional observation tests or motor activity; no significant reductions in fertility or changes in other reproductive parameters; and no evidence of developmental toxicity in offspring. The overall no observed adverse effect concentration was 3000 ppm (approximately 13 600 mg/m 3 ). In conclusion the HSRN effects on liver and kidney are consistent with the results of other studies of volatile fractions or other naphthas or formulated gasoline, and there were no HSRN effects on neurological developmental or reproductive parameters.

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Developmental toxicity evaluation of unleaded gasoline vapor in the rat

Cited by 17 publications

References 7 publications

Prenatal exposure to vapors of gasoline–ethanol blends causes few cognitive deficits in adult rats

Prenatal exposure to vapors of gasoline–ethanol blends causes few cognitive deficits in adult rats

Diesel Oil Vapor Inhalation: Risk Factor for Heart Attack

Toxicological Assessment of Heavy Straight Run Naphtha in a Repeated Dose/Reproductive Toxicity Screening Test

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