Developmental toxicity assessment of arsenic acid in mice and rabbits

Nemec, M.D.; Holson, Joseph F.; Farr, CraigH; Hood, RonaldD

doi:10.1016/s0890-6238(98)00053-7

Cited by 51 publications

(33 citation statements)

References 23 publications

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“…Our data demonstrate that in vivo treatment with arsenite produces meiotic aberrations on in vivo-matured mouse oocytes, in some cases even with doses at the maternal noobserved-adverse-effect-level (8 mg/kg) [31]. Moreover, the effects of arsenite on meiosis clearly were dose-dependent and robust: even with arsenite at only the 16 mg/kg dose, 62.5% of oocytes evaluated showed evidence of meiotic abnormalities.…”

Section: Discussionmentioning

confidence: 62%

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In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse1

Navarro

Liu

Keefe

2004

Biology of Reproduction

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Inorganic arsenic, an environmental contaminant, produces a variety of stress responses in mammalian cells, including metabolic abnormalities accompanied by growth inhibition and carcinogenesis. Much of the toxicity of arsenic is known to stem from its uncoupling effects on mitochondria. Because previously we had shown that mitochondrial dysfunction can disrupt oocyte and embryo development, we investigated effects of arsenite on meiotic progression and early embryo development in mice. Six-week-old CD-1 mice were treated with 0 (solvent as control), 8 mg/kg (a dose previously established in mice as the maternal no-observed-adverse-effect level), and 16 mg/kg doses of sodium arsenite every 2 days for a total of seven i.p. injections ver a period of 14 days. The incidence of meiotic anomalies, characterized by spindle disruption and/or chromosomal misalignment, was significantly increased in arsenite-treated groups (25% after 8 mg/kg and 62.5% after 16 mg/kg), compared to normal metaphase II in control oocytes. Further, arsenite treatment significantly decreased cleavage rates of zygotes at 24 h, morula formation at 72 h, and development to blastocysts at 96 h in a dose-dependent manner. The total cell number in developed blastocysts did not differ significantly between the 8 mg/kg arsenite treatment and control groups, but was significantly reduced in the 16 mg/kg arsenite treatment group. Moreover, the percentage of apoptotic nuclei was significantly increased in blastocysts following 16 mg/kg arsenite treatment. These data suggest that arsenite causes meiotic aberrations, which may contribute to decreased cleavage and preimplantation development, as well as increased apoptosis.

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Section: Discussionmentioning

confidence: 62%

“…We studied arsenite rather than arsenate because of its higher toxicicity [30]. The dose of 8 mg/kg, the maternal no-observed-adverse-effect level (NOAEL), previously established in mice [31] was used in addition to vehicle controls.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse1

Navarro

Liu

Keefe

2004

Biology of Reproduction

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“…Increased liver weight, decreased liver glycogen, vacuolation of hepatocytes, increase heme oxygenase activity, impaired liver mitochondrial respiration and ultrastructural changes in hepatocytes, enlarged bile duct with dilation and inflammation Monkey, rat and mouse Brown et al (1997); Brown and Kitchin (1996); Byron et al (1967, p. 67);Fowler et al (1977); Fowler and Woods (1979); Heywood and Sortwell (1979); Holson et al (2000); Kroes et al (1974); Santra et al (2000) Hematological effects Decreased erythrocyte and leukocyte numbers, decreased ALAD activity and increased platelet aggregation Rat and guinea pig Kannan et al (2001, p. 2002200); Lee et al (2002); Fowler, 1977 (1978) Ocular Byron et al (1967);Fowler et al (1977); Holson et al (2000); Hood et al (1978); Hood and Harrison (1982); Nemec et al (1998); Rodríguez et al (2001); Stump et al (1999) …”

Section: Hepatic Effectsmentioning

confidence: 99%

A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

104

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“…One of the most common fetal malformations in iAs-exposed mice is exencephaly (Hood, 1972;Baxley et al, 1981;Nemec et al, 1998;Hill et al, 2008). Early in gestation, iAs was observed to selectively accumulate in the neuroepithelium (Lindgren et al, 1984) and As 3+ was found to be retained in brain tissue for longer periods of time compared to other valence forms (Vahter and Norin, 1980).…”

Section: Introductionmentioning

confidence: 99%

Locomotor activity and sensory – motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation

Gumilar

Lencinas

Bras

et al. 2015

Neurotoxicology and Teratology

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Please cite this article as: Fernanda Gumilar, Ileana Lencinas, Cristina Bras, Leda Giannuzzi, Alejandra Minetti, Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation, Neurotoxicology and Teratology (2015), doi: 10.1016/j.ntt.2015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTBoth FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.

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Developmental toxicity assessment of arsenic acid in mice and rabbits

Cited by 51 publications

References 23 publications

In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse1

In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse1

A review on exposure and effects of arsenic in passerine birds

Locomotor activity and sensory – motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation

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