Developmental toxicity and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug ketoprofen

Rangasamy, Basuvannan; Hemalatha, Devan; Shobana, Chellappan; Nataraj, Bojan; Ramesh, Mathan

doi:10.1016/j.chemosphere.2018.09.013

Cited by 71 publications

(29 citation statements)

References 89 publications

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“…In some cases, "modified structure of chorda" [69], "body shape" [69], "notochord anomalies", "tail anomalies", and "kinks (wavy, curled, bend)" were employed to describe spinal cord malformations without further distinction [83]. No further publications could be found, directly discussing the different curvatures observed in zebrafish embryos, although-according to the present study-spinal curvature is a group of endpoints quite frequently observed (Table 2); with the literature providing the further examples [55,[84][85][86][87][88][89][90].…”

Section: Sublethal Morphological Alterations In Zebrafish Embryos Witmentioning

confidence: 85%

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

et al. 2020

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Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for acute fish toxicity testing such as the OECD Acute Fish Toxicity Test (TG 203). To provide equivalent sensitivity to the acute fish test, the original FET test was designed to use only four morphological core endpoints: coagulation of the embryo, lack of somite formation, lack of heart beat, and non-detachment of the tail. These endpoints were selected due to (1) their association with mortality, directly or indirectly, (2) improve the practicality for screening by well-trained technical staff, and (3) the endpoints being relatively simple morphological alterations. Results With the growing need to understand the developmental toxicity of compounds found in the environment, the FET protocol has repeatedly been extended to a multitude of additional morphological endpoints that also allow the monitoring of teratogenicity. As the extensive use of the FET test has generated a multitude of observations in the scientific literature, a harmonisation of the terminology used for the description of the morphological effects seen after chemical exposure has become necessary. Conclusion For this end, the present communication provides an overview of both common and selected more specific morphological effects seen in zebrafish embryos after exposure to a wide variety of chemical substances together with suggestions for a harmonised nomenclature.

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Section: Sublethal Morphological Alterations In Zebrafish Embryos Witmentioning

confidence: 85%

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

et al. 2020

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“…32 When ROS content is so excessive that antioxidant defense system cannot eliminate, the antioxidant enzymes will be oxidatively modified, leading to decreased enzyme activity and function. 46,49 Interestingly, in the medium concentration groups, the SOD activity in combined group was higher than that in each single group, which suggested that combined exposure to 10 μg/L CBZ and 5 μg/L Cu induced additive effect on oxidative stress.…”

Section: Discussionmentioning

confidence: 93%

“…Likewise, some antibiotics can inhibit or promote the SOD activity of zebrafish depending on the dose. 46,47 For instance, the activities of SOD in adult zebrafish were promoted significantly in 0.1 and 0.5 mg/L maduramicin exposure group, while it was inhibited at 2.5 mg/L group. 48 The increase of SOD activity might be due to the protection mechanism that eliminates excess ROS to offset oxidative stress.…”

Section: Discussionmentioning

confidence: 95%

Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)

Jia

et al. 2020

Environmental Toxicology

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Various pollutants co‐exist in the aquatic environment such as carbamazepine (CBZ) and copper (Cu), which can cause complex effects on inhabiting organisms. The toxic impacts of the single substance have been studied extensively. However, the studies about their combined adverse impacts are not enough. In the present study, zebrafish were exposed to environmental relevant concentrations of CBZ (1, 10, and 100 μg/L), Cu (0.5, 5, and 10 μg/L) and the mixtures (1 μg/L CBZ + 0.5 μg/L Cu, 10 μg/L CBZ + 5 μg/L Cu, 100 μg/L CBZ + 10 μg/L Cu) for 45 days, the effects on nervous and antioxidant systems of zebrafish were investigated. The results demonstrated that, in comparison with single exposure group, the combined presence of CBZ and Cu exacerbated the effect of antioxidant system (the ability of inhibition of hydroxyl radicals (IHR), superoxide dismutase (SOD), catalase (CAT) and glutathione S‐transferase (GST)) but not nervous system (Acetylcholinesterase [AChE]). The qPCR results supported the changes of corresponding enzymes activities. Hepatic histopathological analysis verified the results of biomarkers. Our work illustrated that the toxicity of mixed pollutants is very complicated, which cannot simply be inferred from the toxicity of single pollutant, and calls for more co‐exposure experiments to better understanding of the co‐effects of pollutants on aquatic organisms.

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“…The muscle tissue was removed carefully and stored. The dissected muscle tissue was stored in formalin for histopathology analysis [30].…”

Section: Nanotoxicity Analysis Of Biosynthesized Silver Nanoparticlesmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles from Streptomyces Spp., Characterization and Evaluating of Its Efficacy against Phomopsis theae and Poria hypolateria in Tea Plants (Camellia sinensis)

Karthik¹,

Ponmurugan²,

Gnanamangai³

et al. 2020

Nano BioMed ENG

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Developmental toxicity and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug ketoprofen

Cited by 71 publications

References 89 publications

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)

Biosynthesis of Silver Nanoparticles from Streptomyces Spp., Characterization and Evaluating of Its Efficacy against Phomopsis theae and Poria hypolateria in Tea Plants (Camellia sinensis)

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