2011
DOI: 10.1073/pnas.1112801108
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Developmental stalling and organ-autonomous regulation of morphogenesis

Abstract: Timing of organ development during embryogenesis is coordinated such that at birth, organ and fetal size and maturity are appropriately proportioned. The extent to which local developmental timers are integrated with each other and with the signaling interactions that regulate morphogenesis to achieve this end is not understood. Using the absolute requirement for a signaling pathway activity (bone morphogenetic protein, BMP) during a critical stage of tooth development, we show that suboptimal levels of BMP si… Show more

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Cited by 43 publications
(39 citation statements)
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“…These observations suggest that an early defect in Foxn1 expression can recover to allow for normal development to ensue. A similar example of a recovery of an early defect in tooth development due to deficient BMP signalling was recently reported, suggesting that this phenomenon of 'developmental stalling' might be a common feature of BMPregulated developmental processes (Miletich et al, 2011).…”
Section: Thymus Organogenesismentioning
confidence: 96%
“…These observations suggest that an early defect in Foxn1 expression can recover to allow for normal development to ensue. A similar example of a recovery of an early defect in tooth development due to deficient BMP signalling was recently reported, suggesting that this phenomenon of 'developmental stalling' might be a common feature of BMPregulated developmental processes (Miletich et al, 2011).…”
Section: Thymus Organogenesismentioning
confidence: 96%
“…Moreover, tissue-specific inactivation of Bmpr1a in epithelial tissues resulted in tooth developmental arrest at the bud stage (Andl et al, 2004;Liu et al, 2005). These data led to the conclusion that Bmp4 is a key Msx1-dependent signal for induction of PEK formation to drive tooth morphogenesis beyond the bud stage (Bei et al, 2000;Miletich et al, 2011;O'Connell et al, 2012;Zhao et al, 2000). However, direct genetic analysis of the requirement for Bmp4 in early tooth morphogenesis has not been documented.…”
Section: Introductionmentioning
confidence: 99%
“…−/− mutant embryos was suggested to be caused by a reduction of mesenchymal Bmp4 mRNA expression in the tooth mesenchyme at E13.5 as detected by in situ hybridization (Miletich et al, 2011 tooth germ explants supplemented with exogenous Bmp4 progressed to the stage of dentin formation whereas the Bmp4 transgene driven by the Msx1 promoter only rescued a low percentage of Msx1 −/− mutant molar tooth germs to early cap stage without further morphogenesis (Bei et al, 2000;Zhao et al, 2000). Thus, although our findings indicate that endogenous mesenchymal Bmp4 plays crucial roles in tooth development, this study reveals an important gap in the understanding of Msx1-mediated regulation of mesenchymal odontogenic activity.…”
Section: Research Articlementioning
confidence: 99%
“…barx1 is required for tooth and musculoskeletal attachment barx1 is required for proper oral tooth development in mice (Miletich et al, 2011), and barx1 is expressed in the pharyngeal dentition in cichlids and zebrafish (Fraser et al, 2009;Sperber and Dawid, 2008). Zebrafish pharyngeal tooth development progresses through initiation, morphogenesis, matrix deposition and attachment (Van der Heyden and Huysseune, 2000).…”
Section: Research Articlementioning
confidence: 99%