Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum

Zhou, Mingfu; Tian, Xiao; Suszkiw, Janusz B.

doi:10.1016/s0006-8993(00)02265-4

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Cell Type-specific Responses1

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2004

2022

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Cited by 4 publications

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“…Neurotrophic factors are also potential targets of lead neurotoxicity because intracerebroventricular application of NGF protected rat pups exposed to lead through the dam's drinking water (0.2% lead acetate) from lead-induced loss of septal cholinergic neurons. However, these tissues did not accumulate lead (Zhou et al 2000). A recent study reported that the NGF's effect on rats postnatally exposed to lead was mediated by alterations in NGF receptor p75 and trkA.…”

Section: Cell Type-specific Responsesmentioning

confidence: 95%