Developmental roles of histone H3 variants and their chaperones

Filipescu, Dan; Szenker, Emmanuelle; Almouzni, Geneviève

doi:10.1016/j.tig.2013.06.002

Cited by 111 publications

(119 citation statements)

References 89 publications

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“…Meanwhile, H3.3 is also distributed in other regions such as cis-regulatory elements Goldberg et al, 2010;Mito et al, 2007), and plays an important part in the regulation of gene expression . However, the chaperon that is responsible for deposition of H3.3 at these regions remains to be identified (Filipescu et al, 2013;Goldberg et al, 2010;Szenker et al, 2011). Taken together, these results suggest that H3.3 is deposited across the genome by dedicated chaperone pathways with respect to chromatin contexts ( Figure 1B).…”

Section: The Properties Of H33 Compared With Its Canonical Counterpartsmentioning

confidence: 86%

“…Canonical H3 are H3.1 and H3.2, which differ at only one amino acid residue, with Cys96 in H3.1 and Ser96 in H3.2 (Szenker et al, 2011). Apart from the canonical H3, multiple variants of H3 have now been identified: the replacement variant H3.3, the centromere-specific variant CENP-A, the testis-specific variant H3t and H3.5, and the primate-specific variants H3.X and H3.Y (Filipescu et al, 2013). H3.3 differs from H3.1 by five amino acids substitutions (S31A, A87S, I89V, G90M, and S96C) ( Figure 1A).…”

Section: Introductionmentioning

confidence: 99%

“…H3.3 Ser31 is located at N-terminal tail and can be phosphorylated (Hake et al, 2005). The residues Ala87, Ile89 and Gly90 are located in the 2 helix of the histone-fold domain, and are important for H3.3 deposition at specific loci in the genome by different histone chaperones (Filipescu et al, 2013). In this review we will focus on the recent progress in our understanding of the biological functions of histone H3.3, as well as its role during development and tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Histone Variant H3.3: A versatile H3 variant in health and in disease

Xiong

Wen

2016

Sci. China Life Sci.

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Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA. H3.3, an ancient and conserved H3 variant, differs from its canonical H3 counterpart by only five amino acids, yet it plays essential and specific roles in gene transcription, DNA repair and in maintaining genome integrity. Here, we review the most recent insights into the functions of histone H3.3, and the involvement of its mutant forms in human diseases.histone variants, H3.3, histone chaperones, development, tumorigenesis

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Section: The Properties Of H33 Compared With Its Canonical Counterpartsmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histone Variant H3.3: A versatile H3 variant in health and in disease

Xiong

Wen

2016

Sci. China Life Sci.

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“…The upregulated expression level of polehole-like protein in mature ovary of P. trituberculatus indicated its involvement in the ovarian development of the swimming crab. Histone h3 of Drosophila was reported to be necessary for fertility (Sakai et al, 2009), suggesting an important role in gametogenesis (Filipescu et al, 2013). Up-regulated expression level of histone h3 in the mature ovary may be beneficial to the developmental of the ovary.…”

Section: Identification Of Ovarian Development-related Estsmentioning

confidence: 99%

Screening of genes related to ovarian development in the swimming crab, Portunus trituberculatus, by suppression subtractive hybridization

Song

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The swimming crab, Portunus trituberculatus, is an important marine animal and is widely cultured in China. In the present study, suppression subtractive hybridization was applied to identify the differentially expressed genes in the ovaries of mature and immature P. trituberculatus. One hundred and seventy six expressed sequence tag (ESTs) were identified, of which 100 were down-regulated, and 76 up-regulated. BLAST analysis identified 51 unigenes, of which 27 were down-regulated, and 24 up-regulated. Quantitative real-time reverse transcriptase polymerase chain reaction results indicated that the SSH technique is valuable in screening genes related to ovarian development. Genes identified in this study encoded proteins corresponding to a wide range of functions and included immune response protein, transcription initiation factor, metabolic proteins, chromosome, histone h3, ovarian development-related protein, and vitellogenin. In addition, 64 metabolic pathways were annotated in differentially expressed ESTs by using the Kyoto Encyclopedia of Genes and Genomes pathway. Four annotated pathways (oxidative phosphorylation, carbon metabolism, fatty acid degradation, and protein digestion and absorption) appeared to be involved in ovarian development. In ontology analysis, 5.83% of the cellular process genes in reverse subtraction cDNA library are involved in reproduction, and 5.88% involved in developmental process. In up-regulated genes, myosin II-expressed polehole-like protein; histone h3; ovigerous-hair stripping substance; peritrophin 48; and ovarian development-related protein appeared to be involved in ovarian development. Identification of differentially expressed genes in the mature and immature ovary of the swimming crab provides new insights for further studies on the mechanism underlying ovarian development in this species.

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“…13 In mammals, the histone variant H3.3 is encoded by two different genes (h3f3a and h3f3b) whose translation results in an identical protein product (H3.3A and H3.3B) that differs from the canonical H3 isoforms by only 4 or 5 amino acids. [25][26][27] Maternal H3.3 is incorporated into the decondensing sperm nucleus and is required for formation of the male pronucleus during fertilization, [28][29][30][31] and is critical for the development and genomic integrity of pre-implantation embryos during early embryogenesis. 32 In addition, deposition of this replacement histone offers the potential to alter chromatin landscapes without the need for enzymatic removal of histone modifications.…”

Section: Introductionmentioning

confidence: 99%

H3.3 replacement facilitates epigenetic reprogramming of donor nuclei in somatic cell nuclear transfer embryos

Wen

Banaszynski

Rosenwaks

et al. 2014

Nucleus

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T ransfer of a somatic nucleus into an enucleated oocyte is the most efficient approach for somatic cell reprogramming. While this process is known to involve extensive chromatin remodeling of the donor nucleus, the maternal factors responsible and the underlying chromatin-based mechanisms remain largely unknown. Here we discuss our recent findings demonstrating that the histone variant H3.3 plays an essential role in reprogramming and is required for reactivation of key pluripotency genes in somatic cell nuclear transfer (SCNT) embryos. Maternal-derived H3.3 replaces H3 in the donor nucleus shortly after oocyte activation, with the amount of replacement directly related to the differentiation status of the donor nucleus in SCNT embryos. We provide additional evidence to suggest that de novo synthesized H3.3 replaces histone H3 carrying repressive modifications in the donor nuclei of SCNT embryos, and hypothesize that replacement may occur at specific loci that must be reprogrammed for gene reactivation.

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Developmental roles of histone H3 variants and their chaperones

Cited by 111 publications

References 89 publications

Histone Variant H3.3: A versatile H3 variant in health and in disease

Histone Variant H3.3: A versatile H3 variant in health and in disease

Screening of genes related to ovarian development in the swimming crab, Portunus trituberculatus, by suppression subtractive hybridization

H3.3 replacement facilitates epigenetic reprogramming of donor nuclei in somatic cell nuclear transfer embryos

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