Developmental Resting State Functional Connectivity for Clinicians

Hulvershorn, Leslie A.; Cullen, Kathryn R.; Francis, Michael; Westlund, Melinda K.

doi:10.1007/s40473-014-0020-3

Cited by 15 publications

(9 citation statements)

References 85 publications

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“…The precuneus is active when individuals view familiar information, potentially to help direct resources to the proper internal representations (maintained via hippocampal-prefrontal interactions) (Cavanna and Trimble 2006). The precuneus has also been identified as an important node in modulating default mode and attentional networks (Fransson and Marrelec 2008) and has been shown to have altered activation in default mode network (DMN) studies of schizophrenia (Hulvershorn et al 2014). Altered function in the precuneus could be related to deficient EM functioning in various ways, including an impaired ability to make accurate assessments of familiarity.…”

Section: Discussionmentioning

confidence: 99%

Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Francis

Hummer

Vohs

et al. 2015

Brain Imaging and Behavior

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Studies have demonstrated that episodic memory (EM) is often preferentially disrupted in schizophrenia. The neural substrates that mediate EM impairment in this illness are not fully understood. Several functional magnetic resonance imaging (fMRI) studies have employed EM probe tasks to elucidate the neural underpinnings of impairment, though results have been inconsistent. The majority of EM imaging studies have been conducted in chronic forms of schizophrenia with relatively few studies in early phase patients. Early phase schizophrenia studies are important because they may provide information regarding when EM deficits occur and address potential confounds more frequently observed in chronic populations. In this study, we assessed brain activation during the performance of visual scene encoding and recognition fMRI tasks in patients with earlyphase psychosis (n=35) and age, sex, and race matched healthy control subjects (n = 20). Patients demonstrated significantly lower activation than controls in the right hippocampus and left fusiform gyrus during scene encoding and lower activation in the posterior cingulate, precuneus, and left middle temporal cortex during recognition of target scenes. Symptom levels were not related to the imaging findings, though better cognitive performance in patients was associated with greater right hippocampal activation during encoding. These results provide evidence of altered function in neuroanatomical circuitry subserving EM early in the course of psychotic illness, which may have implications for pathophysiological models of this illness.

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Section: Discussionmentioning

confidence: 99%

Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Francis

Hummer

Vohs

et al. 2015

Brain Imaging and Behavior

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“…32 We selected a whole-brain seed-to-voxel analysis approach to test a priori hypotheses involving specific neural networks, and to facilitate comparisons with the extant resting-state fMRI literature on adolescent MDD. 14,15,33,34 We generated whole-brain seed-to-voxel correlation maps by extracting the residual Blood Oxygenation Level Dependent (BOLD) signal time course from a priori regions of interest, including the amygdala (limbic network), anterior insula (salience network), and dorsolateral prefrontal cortex (executive control network) ( Figure 1). Seed regions were 5 mm in diameter and created based on peak coordinates from the literature.…”

Section: Seed-based Functional Connectivity Analysesmentioning

confidence: 99%

Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder

Fischer

Camacho

et al. 2018

JAMA Psychiatry

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“…The connections between brain regions measured by RSFC may be a function of direct communication via structural connections, association with a third region, and/or long-term patterns of coordinated activity engaged during certain behaviors or psychological processes. Functional connectivity can be positive or negative, reflecting the direction of correlation in regional activity patterns ( Hulvershorn et al, 2014 ). The type of connectivity patterns observed indicates the nature of the functional relationship between these regions.…”

Section: Introductionmentioning

confidence: 99%

Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks

Weissman

Schriber

Fassbender

et al. 2015

Developmental Cognitive Neuroscience

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Background Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Method Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. Results The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. Discussion The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.

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Developmental Resting State Functional Connectivity for Clinicians

Cited by 15 publications

References 85 publications

Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder

Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks

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