Developmental regression: assessment and investigation

Holland, Jonathon; Brown, Richard

doi:10.1016/j.paed.2017.01.013

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Over the last two decades, several reviews have described the phenomenon of regression with a main focus on the prevalence, onset, and types of skills that are lost (e.g., Barger et al, 2013;Holland & Brown, 2017;Matson & Kozlowski, 2010;Rogers, 2004;Stefanatos, 2008;Williams et al, 2015). Concerning the etiology of regression, there has been a sizeable number of studies on the relationship with epilepsy which were recently reviewed by Barger, Campbell and Simmons (2017).…”

Section: Introductionmentioning

confidence: 99%

Regression in autism spectrum disorder: A critical overview of retrospective findings and recommendations for future research

Boterberg

Charman

Marschik

et al. 2019

Neuroscience & Biobehavioral Reviews

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Section: Introductionmentioning

confidence: 99%

Regression in autism spectrum disorder: A critical overview of retrospective findings and recommendations for future research

Boterberg

Charman

Marschik

et al. 2019

Neuroscience & Biobehavioral Reviews

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Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis was broad and included central nervous system infection and inflammatory conditions, structural brain lesion, neurodegenerative disease, and neuromuscular disorder (Table 1). 5,6 The most pressing possibility for this patient was a structural brain lesion because progressive subacute muscle weakness may be seen in children with an expanding brain tumor. A central nervous system infection was another major concern, but the lack of fever, meningeal signs, and cerebrospinal findings argued against it.…”

Section: Discussionmentioning

confidence: 99%

A 15-Month-Old With Developmental Regression and Hypotonia

Chan

Jun-Ihn

Shrestha

et al. 2022

Clin Pediatr (Phila)

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A 15-month-old previously healthy girl child presented to the clinic for developmental regression and hypotonia. One month prior to presentation, she had 1 day of vomiting, which resolved, but subsequently developed worsening fatigue and eventually regression in developmental milestones. Although she talked and walked before, she stopped sitting and walking independently, requiring caregiver assistance. She also stopped eating on her own. On review of systems, she did not have any fever, abdominal pain, bloating, diarrhea, or constipation. She also did not have any preceding injury, toxic exposures, recent travel, or pertinent medical or family history. She ate a balanced diet with no restrictions.On physical examination, she was thin and pale. She was slumped over her caregiver's lap with her mouth open, suggesting poor overall tone. She made minimal sounds and movements. While able to follow a few commands, she was reluctant to engage with the examiner. Notably, she had intact deep tendon reflexes. Review of the growth chart revealed poor growth over the previous 4 months (Figure 1). Given her appearance and neurodevelopmental regression, she was urgently referred to the hospital for expedited workup.A neurologic evaluation was prioritized given the acute regression. Magnetic resonance imaging of the brain and spine was normal. Cerebrospinal fluid studies were negative for any infectious or inflammatory etiologies. Other infectious blood and stool studies were negative. Labs were notable for an elevated stool calprotectin (374 µg/g, ref.<286 µg/g), elevated stool alpha-1antitrypsin (1.13 mg/g, ref. <0.5 mg/g), and low serum albumin (1.8 g/dL, ref. >4.0 g/dL), suggesting proteinlosing enteropathy. Other tests were significant for deficiencies in copper, zinc, vitamin B6, vitamin B9, vitamin E, and vitamin D; but normal levels of vitamin B12 and other essential minerals, including sodium, potassium, calcium, and phosphorous. Thyroid-stimulating hormone was normal. Urine organic acids, plasma amino acids, lactate, pyruvate, and ammonia as well as trio exome sequencing were performed to rule out metabolic and genetic causes, such as leukoencephalopathies and encephalopathies, from inborn errors of metabolism that would result in hyperammonemia and lactic acidemia-all studies were negative. Finally, celiac disease antibody testing, esophagogastroduodenoscopy, and colonoscopy were pursued.

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“…Обратимая регрессия является постепенным длительным процессом, и не относится к единовременной потере определенных функций организма -например, в результате черепно-мозговой травмы [25].…”

Section: Guidelines For the Practitioner в помощь практикующему врачуunclassified

Reversible regression in early childhood

Makarov¹,

Краснощеков²

2021

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

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Summary. The article (didactic material) addresses the following aspects of the study of reversible regression in early childhood: question history, systematics, regression symptoms, including in childhood autism. The authors analyze the available data, express the opinion that the possibilities of reversible regression therapy in children have not been studied, there are no accurate data on the pathogenesis of these disorders, indicate the need to assess the dynamics of the condition, taking into account the age and sex factors of the child.The authors conclude that reversible regression is a pathological condition developing against a background of relatively favorable child development, in which there is a prolonged decay of previously acquired skills followed by partial or complete recovery. Unlike dementia, which is an irreversible process, regression has the stage of restoring lost functions. In studying the issue, clinical-dynamic analysis of variants of reversible regression of early childhood, an understanding of gender and age differences in the symptoms of the disorder, and prognosis criteria.

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Developmental regression: assessment and investigation

Cited by 7 publications

References 5 publications

Regression in autism spectrum disorder: A critical overview of retrospective findings and recommendations for future research

Regression in autism spectrum disorder: A critical overview of retrospective findings and recommendations for future research

A 15-Month-Old With Developmental Regression and Hypotonia

Reversible regression in early childhood

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