Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation

Andersen, D.; Tannenberg, A. E. G.; Burke, Christopher; Dodd, Peter R.

doi:10.1016/0165-3806(95)00101-i

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…NMDA receptor binding was determined using a method previously described by Andersen et al (1995) using [ 3 H]-MK801 as the selective radioligand. The incubation mixture for the determination of total binding consisted of 300 ml membrane suspension to which 50 ml [ 3 H]-MK801 was added.…”

Section: Assay Methodologiesmentioning

confidence: 99%

Stress?restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

et al. 2003

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Section: Assay Methodologiesmentioning

confidence: 99%

Stress?restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

et al. 2003

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“…If we restrict our attention just to studies of fetal and adult human and monkey cerebral cortex, a number of classical neurotransmitters (GABA, glutamate, monoamines), neuropeptides, and transmitterrelated enzymes or other signalling molecules have been described. In humans, subplate neurons express GABA (Schiffmann et al 1988;Yan et al 1992;Masood et al 1993;Zecevic & Milosevic, 1997), vesicular GABA transporter, a potassium ⁄ chloride co-transporter (KCC2) (Bayatti et al 2008), various glutamate receptors (Lee & Choi, 1992;Andersen et al 1995;Ritter et al 2001;Talos et al 2006), AChE (Kostovic & Rakic, 1980;Kostović et al 1981;Kostović, 1984), and nicotinic acetylcholine receptors (Schrö der et al 2001). In the monkey, subplate neurons also express GABA (Huntley et al 1988;Meinecke & Rakic, 1992;Tomioka & Rockland, 2007) and GABA-A receptors (Huntley et al 1990;Meinecke & Rakic, 1992).…”

Section: Neurochemical Diversitymentioning

confidence: 99%

Populations of subplate and interstitial neurons in fetal and adult human telencephalon

et al. 2010

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In the adult human telencephalon, subcortical (gyral) white matter contains a special population of interstitial neurons considered to be surviving descendants of fetal subplate neurons [Kostovic & Rakic (1980) Cytology and the time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. J Neurocytol 9, 219]. We designate this population of cells as superficial (gyral) interstitial neurons and describe their morphology and distribution in the postnatal and adult human cerebrum. Human fetal subplate neurons cannot be regarded as interstitial, because the subplate zone is an essential part of the fetal cortex, the major site of synaptogenesis and the 'waiting' compartment for growing cortical afferents, and contains both projection neurons and interneurons with distinct input-output connectivity. However, although the subplate zone is a transient fetal structure, many subplate neurons survive postnatally as superficial (gyral) interstitial neurons. The fetal white matter is represented by the intermediate zone and well-defined deep periventricular tracts of growing axons, such as the corpus callosum, anterior commissure, internal and external capsule, and the fountainhead of the corona radiata. These tracts gradually occupy the territory of transient fetal subventricular and ventricular zones.The human fetal white matter also contains distinct populations of deep fetal interstitial neurons, which, by virtue of their location, morphology, molecular phenotypes and advanced level of dendritic maturation, remain distinct from subplate neurons and neurons in adjacent structures (e.g. basal ganglia, basal forebrain). We describe the morphological, histochemical (nicotinamide-adenine dinucleotide phosphate-diaphorase) and immunocytochemical (neuron-specific nuclear protein, microtubuleassociated protein-2, calbindin, calretinin, neuropeptide Y) features of both deep fetal interstitial neurons and deep (periventricular) interstitial neurons in the postnatal and adult deep cerebral white matter (i.e. corpus callosum, anterior commissure, internal and external capsule and the corona radiata ⁄ centrum semiovale). Although these deep interstitial neurons are poorly developed or absent in the brains of rodents, they represent a prominent feature of the significantly enlarged white matter of human and non-human primate brains.

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“…Moreover, it will be of interest to determine whether the case-to-case variation in spermine responses arises from differing individual combinations of spermine-responsive glutamate-NMDA receptor subunits. Our study of [3H]MK-801 binding sites in human infants showed marked regional variations in glutamate activation profiles, as well as in the developmental changes in such curves (Andersen et al 1995).…”

Section: Discussionmentioning

confidence: 57%

The Modulatory Effect of Spermine on the Glutamate‐NMDA Receptor is Regionally Variable in Normal Human Adult Cerebral Cortex

Mortensen

Matsumoto

Niwa

et al. 1999

Pharmacology & Toxicology

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Abstruct:The MK-801, glutamate and polyamine binding sites on the N-methy1-D-aspartate class of glutamate receptors labelled with [3H]MK-801 were characterized in four cortical areas (sensorimotor, superior temporal, mid-frontal and occipital) from seven human adult control cases. Age, post-mortern delay, tissue storage time and sex had no significant effects on any of the parameters measured. Dissociation constants (K, values) for MK-801 showed similar mean values in the four cortical areas. whereas receptor densities (B,,, values) showed significant differences between sensorimotor or occipital and superior temporal or mid-frontal cortex. There were marked regional differences in the profiles of the spermine-and glutamate-increniented enhancement of specific [3H]MK-801 binding. The ECSo for the glutamate enhancement was significantly higher in the occipital than in the mid-frontal and sensorimotor cortex. whereas maximal glutamate- The N-methybaspartate (NMDA) class of ionotropic glutamate receptors plays a central role in excitatory neurotransmission in the central nervous system (Monaghan et a/. 1989). Glutamate-NMDA receptors are found on many synapses, and are important in synaptic plasticity, epilepsy, neuronal death and antinociception (Choi 1988;Bliss & Collingridge 1993; Luger et d. 1995). The receptor channel complex is composed of five different subunits permutated from the eight N R I splice variants and four NR2 subunit isoform proteins (Durand et al. 1993;Zukin & Bennett 1995;Blahos & Wenthold 1996). In vitro expression studies have shown that receptor complexes of differing subunit composition possess distinct pharmacological and physiological properties (Katsuwada et al. 1992; Monyer et ul. 1992;Wafford et al. 1993;Laube et al. 1998), which may derive from the conformational responsiveness of the receptor or the configuration of ligand sites. The receptor complex contains a number of distinct recognition sites for a range of ligands (Williams et al. 199 I), which if stimulated in combination can result in complex pharmacological responses. This complexity of structure and pharmacology makes it likely that glutamate-NMDA receptors would show variability between individuals. The goal of these studies was to characterize the pharmacology of glutamate-NMDA receptor sites for MKAuthor for correspondence: Peter R. Dodd. Department of Biochemistry, University of Queensland, Brisbane 4072, Australia (fax +61 73 365 4699. e-mail peterD@biosci.uq.edu.au). 80 1 (Dizocilpine), glutamate and spermhe in four cortical areas from normal human cases. Materials and MethodsCuse niuteriul. Brain tissue was collected at autopsy. A full postrizorterii examination was carried out on each case by an anatomical pathologist and the cause of death determined. Informed written consent was obtained from the next of kin for each of the autopsies, which were performed at Brisbane hospitals. Ethical clearance was obtained from each hospital ethics committee, and is current at Royal Brisbane Hospital under Protocol 1992122. All...

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Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation

Cited by 15 publications

References 16 publications

Stress?restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

Stress?restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

Populations of subplate and interstitial neurons in fetal and adult human telencephalon

The Modulatory Effect of Spermine on the Glutamate‐NMDA Receptor is Regionally Variable in Normal Human Adult Cerebral Cortex

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