Developmental programming of adult haematopoiesis system

Balistreri, Carmela Rita; Garagnani, Paolo; Madonna, Rosalinda; Vaiserman, Alexander; Melino, Gerry

doi:10.1016/j.arr.2019.100918

Cited by 22 publications

(20 citation statements)

References 215 publications

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“…In addition, the concomitant deregulation of Notch-1 pathways, previously observed in BAV cases 15 , might also justify the reduced numbers of circulating T and B subsets and EPC 14,15 . These two pathways are, indeed, known to play a crucial role in physiological haematopoiesis 29,30 , the physiological release and functionality of progenitors, such as EPC 8,30,31 , as well as in embryological organogenesis and valvulogenesis 1,16,23,30,32 .…”

Section: Discussionmentioning

confidence: 99%

Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

Balistreri

Marullo

Madonna

et al. 2019

Sci Rep

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Bicuspid aortic valve (BAV) disease is recognized to be a syndrome with a complex and multifaceted pathophysiology. Its progression is modulated by diverse evolutionary conserved pathways, such as Notch-1 pathway. Emerging evidence is also highlighting the key role of TLR4 signaling pathway in the aortic valve pathologies and their related complications, such as sporadic ascending aorta aneurysms (AAA). Consistent with these observations, we aimed to evaluate the role of TLR4 pathway in both BAV disease and its common complication, such as AAA. To this aim, 70 subjects with BAV (M/F 50/20; mean age: 58.8 ± 14.8 years) and 70 subjects with tricuspid aortic valve (TAV) (M/F 35/35; mean age: 69.1 ± 12.8 years), with and without AAA were enrolled. Plasma assessment, tissue and gene expression evaluations were performed. Consistent with data obtained in the previous study on immune clonotypic T and B altered responses, we found reduced levels of systemic TNF-α, IL-1, IL-6, IL-17 cytokines in BAV cases, either in the presence or absence of AAA, than TAV cases (p < 0.0001 by ANOVA test). Interestingly, we also detected reduced levels of s-TLR4 in BAV cases with or without AAA in comparison to the two groups of TAV subjects (p < 0.0001 by ANOVA test). These results may suggest a deregulation in the activity or in the expression of TLR4 signaling pathway in all BAV cases. Portrait of these data is, indeed, the significantly decreased gene expression of inflammatory cytokines and TLR4, in both normal and aneurysmatic tissue samples, from BAV with AAA than TAV with AAA. In conclusion, our study demonstrates that subjects with BAV display a significant deregulation of TLR4 signaling pathway paralleled by a deregulation of Notch-1 pathway, as previously showed. This data suggests that the crosstalk between the Notch-1 and TLR4 signaling pathways may play a crucial role in both physiological embryological development, and homeostasis and functionality of aortic valve in adult life.

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Section: Discussionmentioning

confidence: 99%

Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

Balistreri

Marullo

Madonna

et al. 2019

Sci Rep

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“…Although the traditional threshold segmentation method is very convenient and simple to implement, the inevitable speckle noise and complex texture in ultrasound images make it difficult to obtain satisfactory results. Mean Shift algorithm aims to segment images into regions with semantic meaning, and has been widely used in the field of medical image processing [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Idiopathic Premature Ovarian Failure by Color Doppler Ultrasound under the Intelligent Segmentation Algorithm

Qing

2022

Computational and Mathematical Methods in Medicine

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The aim of this study was to explore the application value of transvaginal color Doppler ultrasound based on the improved mean shift algorithm in the diagnosis of idiopathic premature ovarian failure (POF). In this study, 80 patients with idiopathic POF were selected and included in the experimental group, and 40 volunteers who underwent health examinations during the same period were selected and included in the control group, who underwent transvaginal Doppler ultrasound examination. At the same time, an improved mean shift algorithm was proposed based on artificial intelligence technology and applied to ultrasound image processing. In addition, the ovarian artery parameters of patients were compared in two groups, including peak systolic flow rate (PSV), diastolic flow rate (EDV), resistance index (RI), and pulsatile index (PI). The results showed that the relative difference degree (RDD) of the segmentation results of the algorithm in this study was significantly lower than that of Snake, Live_wire, and the traditional mean shift algorithm, while the relative overlap degree (ROD) and Dice coefficient were opposite, and the differences were significant (P<0.05). The mediolateral diameter of control group was 2.87±0.31cm, and the anteroposterior diameter was 1.86±0.28 cm; while those were 2.11±0.36 cm and 1.13±0.34 cm, respectively, in the experimental group, showing significant differences between the groups (P<0.05). Of the 80 patients in the experimental group, 132 cases with ovarian arteries were found; among 40 patients in the experimental group, 76 cases were found with ovarian arteries, and the hemodynamic detection rate of the experimental group was significantly lower than that of the control group (P<0.05). The ovarian artery parameters PI, RI, and S/D of the experimental group were significantly higher than those of the control group, and the differences were statistically significant (P<0.05). The results showed that the segmentation results of the improved algorithm in this study were more superior to the segmentation results of other algorithms. The regional information loss of the segmentation results was not serious, and the resolution was higher and the definition was higher. The transvaginal color Doppler ultrasound based on the artificial intelligence segmentation algorithm can clearly show the functional status and hemodynamics of the patient’s ovaries. The ovarian artery parameters PI and RI can be used as specific indicators for evaluating the POF.

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“…Consequently, patient-specific iPSCs could provide a source of unlimited disease-relevant cells in a personalized manner, including cardiomyocytes, which have been previously inaccessible. However, to use iPSCs, their genome instability, epigenetic memory associated with the reprogramming process [28,44], and their maintenance represent important limitations to their effective application. Indeed, these factors exemplify the very issues in achieving the integrity of iPSC cellular derivatives and creating accurate models of diseases [43].…”

Section: Multi-omics Approaches 3d and 4d Systems And Innovativementioning

confidence: 99%

On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches

Scola

Giarratana

Torre

et al. 2019

IJMS

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The need to facilitate the complex management of cardiometabolic diseases (CMD) has led to the detection of many biomarkers, however, there are no clear explanations of their role in the prevention, diagnosis or prognosis of these diseases. Molecules associated with disease pathways represent valid disease surrogates and well-fitted CMD biomarkers. To address this challenge, data from multi-omics types (genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, and nutrigenomics), from human and animal models, have become available. However, individual omics types only provide data on a small part of molecules involved in the complex CMD mechanisms, whereas, here, we propose that their integration leads to multidimensional data. Such data provide a better understanding of molecules related to CMD mechanisms and, consequently, increase the possibility of identifying well-fitted biomarkers. In addition, the application of gender medicine also helps to identify accurate biomarkers according to gender, facilitating a differential CMD management. Accordingly, the impact of gender differences in CMD pathophysiology has been widely demonstrated, where gender is referred to the complex interrelation and integration of sex (as a biological and functional marker of the human body) and psychological and cultural behavior (due to ethnical, social, and religious background). In this review, all these aspects are described and discussed, as well as potential limitations and future directions in this incipient field.

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Developmental programming of adult haematopoiesis system

Cited by 22 publications

References 215 publications

Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

Diagnosis of Idiopathic Premature Ovarian Failure by Color Doppler Ultrasound under the Intelligent Segmentation Algorithm

On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches

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