Developmental programming and ageing of male reproductive function

Zambrano, Elena; Nathanielsz, Peter W.; Rodríguez-González, Guadalupe L.

doi:10.1111/eci.13637

Cited by 12 publications

(14 citation statements)

References 99 publications

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“…According to the developmental origins of health and disease hypothesis, offspring of obese mothers are at greater risk of developing obesity, diabetes, and cardiovascular disorders in adult life [ 5 ]. Several mechanisms have been proposed that link perinatal challenges with the development of diseases later in life, such as altered placental function, changes in the endocrine milieu, and epigenetic modifications [ 6 , 7 ]. However, oxidative stress, defined as an imbalance of pro-oxidants and antioxidants, is a key mechanism by which maternal obesity drives developmental programming, as the developing fetus is particularly vulnerable to oxidative stress due to its inadequate antioxidant defense mechanisms [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

et al. 2022

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Maternal obesity (MO) causes maternal and fetal oxidative stress (OS) and metabolic dysfunction. We investigated whether supplementing obese mothers with resveratrol improves maternal metabolic alterations and reduces OS in the placenta and maternal and fetal liver. From weaning through pregnancy female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating until 19 days’ gestation (dG), half the rats received 20 mg resveratrol/kg/d orally (Cres and MOres). At 19dG, maternal body weight, retroperitoneal fat adipocyte size, metabolic parameters, and OS biomarkers in the placenta and liver were determined. MO mothers showed higher body weight, triglycerides and leptin serum concentrations, insulin resistance (IR), decreased small and increased large adipocytes, liver fat accumulation, and hepatic upregulation of genes related to IR and inflammatory processes. Placenta, maternal and fetal liver OS biomarkers were augmented in MO. MOres mothers showed more small and fewer large adipocytes, lower triglycerides serum concentrations, IR and liver fat accumulation, downregulation of genes related to IR and inflammatory processes, and lowered OS in mothers, placentas, and female fetal liver. Maternal resveratrol supplementation in obese rats improves maternal metabolism and reduces placental and liver OS of mothers and fetuses in a sex-dependent manner.

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Section: Introductionmentioning

confidence: 99%

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

et al. 2022

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“…Epigenetic changes (Yatsenko and Turek, 2018;Zambrano et al, 2021) Inappropriate redox balance (Beattie et al, 2015;Weir and Robaire, 2007) Decreased UPR-related proteins (Cavalcante et al, 2020;Zhao et al, 2019) Apoptosis (Akbari et al, 2022;Zhao et al, 2019) decline in oocyte quality and quantity is multifactorial and is poorly understood. One of the most central determinants of oocyte quality is chromosome segregation during meiosis.…”

Section: The Molecular Mechanisms Underlying Age-associatedmentioning

confidence: 99%

“…Paternal aging leads to lowered genetic quality of sperm production and is characterized by increases in DNA damage and fragmentation, mutations, and aneuploidies (Yatsenko and Turek, 2018). Moreover, various epigenetic changes, including aberrant DNA methylation, are another major factor that contributes to lowered sperm quality (Yatsenko and Turek, 2018;Zambrano et al, 2021). The antioxidant enzymatic activities of GPX1, GPX4, and SOD in aged sperm are diminished, resulting in redox imbalance (Weir and Robaire, 2007).…”

Section: Aging Of the Male Reproductive Systemmentioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

174

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Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

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“…The paper by Zambrano et al 8 , 'Developmental Programming and Aging of Male Reproductive Function', approaches the issue of ageing-developmental programming interactions in male reproduction from a wide perspective on many components of the male reproductive system. The focus is on key factors involved in reproductive ageing such as decreased hormone production, DNA fragmentation, oxidative stress, telomere shortening, epigenetics, maternal lifestyle and nutrition.…”

Section: General Review Of Contents By Peter Nathanielszmentioning

confidence: 99%