Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary

Kotwica, Joanna; Larson, Maureen K.; Bębas, Piotr; Giebułtowicz, Jadwiga M.

doi:10.1016/j.jinsphys.2009.01.017

Cited by 14 publications

(15 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, they undergo differentiation and adjust their size and function to differentiating gametes. We have previously shown that PER is expressed in D. melanogaster follicle cells surrounding oocytes, however, PER expression is nonrhythmic under either LD or DD (Beaver et al, 2003) and is developmentally regulated (Kotwica et al, 2009b). Thus, cyst cells in S. littoralis appear to represent an intermediate situation between non-rhythmic and circadian state, such that PER show nuclear oscillations in LD, but is constant in DD.…”

Section: Discussionmentioning

confidence: 96%

Diurnal rhythm in expression and release of yolk protein in the testis of Spodoptera littoralis (Lepidoptera: Noctuidae)

Kotwica

Joachimiak

Polańska

et al. 2011

Insect Biochemistry and Molecular Biology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Diurnal rhythm in expression and release of yolk protein in the testis of Spodoptera littoralis (Lepidoptera: Noctuidae)

Kotwica

Joachimiak

Polańska

et al. 2011

Insect Biochemistry and Molecular Biology

Self Cite

View full text Add to dashboard Cite

“…The same brightness parameters and other image settings were used for comparison of young and old tissues. For whole mounts, dissected abdominal organs were fixed and processed as described (Kotwica et al, 2009) and stained with anti-PER followed by Alexa 488 (Invitrogen, xx) secondary antibodies.…”

Section: Methodsmentioning

confidence: 99%

Effects of Aging on the Molecular Circadian Oscillations inDrosophila

Rakshit

Krishnan

Guzik

et al. 2012

Chronobiology International

Self Cite

View full text Add to dashboard Cite

Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the core transcriptional clock, or weakening of the clock-output pathways, or both. The authors monitored age-related changes in behavioral and molecular rhythms in Drosophila melanogaster. Aging was associated with disrupted rest/activity patterns and lengthening of the free-running period of the circadian locomotor activity rhythm. The expression of core clock genes was measured in heads and bodies of young, middle-aged, and old flies. Transcriptional oscillations of four clock genes, period, timeless, Par domain protein 1ε, and vrille, were significantly reduced in heads, but not in bodies, of aging flies. It was determined that reduced transcription of these genes was not caused by the deficient expression of their activators, encoded by Clock and cycle genes. Interestingly, transcriptional activation by CLOCK-CYCLE complexes was impaired despite reduced levels of the PERIOD repressor protein in old flies. These data suggest that aging alters the properties of the core transcriptional clock in flies such that both the positive and the negative limbs of the clock are attenuated.

show abstract

“…Clock gene expression has been observed in the ovaries of the silkworm (Bombyx mori; [33]), prawn (Macrobrachium rosenbergii; [34]) and the fruit fly (Drosophila melanogaster; [35–39]). Although circadian rhythms and/or functional consequences of clock gene expression have not been described in the silkworm or prawn, these parameters have been described in the fruit fly.…”

Section: The Circadian Clock In the Ovary: Form And Functionmentioning

confidence: 99%

“…Although circadian rhythms and/or functional consequences of clock gene expression have not been described in the silkworm or prawn, these parameters have been described in the fruit fly. In Drosophila ovaries, clock genes ( period and timeless ) are present but not rhythmically expressed [38, 39]. Mutant flies lacking functional period (per 01 ) or timeless (tim 0 1 ) gene expression produce fewer mature oocytes and progeny after mating with a wild-type male [38].…”

Section: The Circadian Clock In the Ovary: Form And Functionmentioning

confidence: 99%

Circadian clocks in the ovary

Sellix

Menaker

2010

Trends in Endocrinology & Metabolism

View full text Add to dashboard Cite

Clock gene expression has been observed in tissues of the hypothalamic-pituitary-gonadal (HPG) axis. While the contribution of hypothalamic oscillators to the timing of reproductive biology is well known, the role of peripheral oscillators like those in the ovary is less clear. Circadian clocks in the ovary may play a role in the timing of ovulation. Disruption of the clock in ovarian cells or desynchrony between ovarian clocks and circadian oscillators elsewhere in the body may contribute to the onset and progression of various reproductive pathologies. Here we review evidence for clock function in the ovary across multiple species and offer a novel perspective on the role of this clock in normal ovarian physiology and in diseases that negatively impact fertility.

show abstract

Developmental profiles of PERIOD and DOUBLETIME in Drosophila melanogaster ovary

Cited by 14 publications

References 51 publications

Diurnal rhythm in expression and release of yolk protein in the testis of Spodoptera littoralis (Lepidoptera: Noctuidae)

Diurnal rhythm in expression and release of yolk protein in the testis of Spodoptera littoralis (Lepidoptera: Noctuidae)

Effects of Aging on the Molecular Circadian Oscillations inDrosophila

Circadian clocks in the ovary

Contact Info

Product

Resources

About