Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies

Eisa-Beygi, Shahram; Ekker, Marc; Moon, Thomas W.; Macdonald, R. Loch; Wen, Xiao‐Yan

doi:10.1016/j.reprotox.2014.04.001

Cited by 18 publications

(13 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did observe abnormal cartilage morphology similar to previous reports of statin treatment (Signore et al, 2016). Altered scxa expression pattern was also observed for many of the chemical treatments, which could result from the chemicals targeting pathways associated with cell migration (Eisa-Beygi et al, 2014;Thorpe et al, 2004) and the cytoskeleton (Giger and David, 2017;Kardash et al, 2010;Xu et al, 2012). Interestingly, we found many of the expanded scxaexpressing cells within the periphery of the cartilage elements, corresponding to perichondrium, suggesting the expanded scxa cells arise from perichondrial cells.…”

Section: Discussionsupporting

confidence: 88%

The mevalonate pathway is a critical regulator of tendon cell specification

et al. 2020

View full text Add to dashboard Cite

Tendons and ligaments are crucial components of the musculoskeletal system, yet the pathways specifying these fates remain poorly defined. Through a screen of known bioactive chemicals in zebrafish, we identified a new pathway regulating tendon cell induction. We established that statin, through inhibition of the mevalonate pathway, causes an expansion of the tendon progenitor population. Co-expression and live imaging studies indicate that the expansion does not involve an increase in cell proliferation, but rather results from re-specification of cells from the neural crest-derived sox9a + /sox10 + skeletal lineage. The effect on tendon cell expansion is specific to the geranylgeranylation branch of the mevalonate pathway and is mediated by inhibition of Rac activity. This work establishes a novel role for the mevalonate pathway and Rac activity in regulating specification of the tendon lineage.

show abstract

Section: Discussionsupporting

confidence: 88%

The mevalonate pathway is a critical regulator of tendon cell specification

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Overall, the observed lower mRNA transcription levels of Vasa , FPS , PX1, PTGS2, EcR , and RXR genes in H 2 O 2 ‐treated C. rogercresseyi females may indicate negative effects in the reproduction of the exposed parasites. We did not detect, however, significant differences (Sidak multiple comparisons) in the expression levels of Phb2 (main effects of sex and H 2 O 2 treatment p < .05; interaction p < .05) and HMGR (main effects of sex p = .89, H 2 O 2 treatment p = .18; interaction p < .05), genes previously associated with gametogenesis (Mao, Wang, Lan, Zhou, & Yang, ; Mao, Wang, Zhou, & Yang, ; Sanz et al., ), and sterol/isoprenoid biosynthesis (Eisa‐Beygi, Ekker, Moon, Macdonald, & Wen, ; Friesen & Rodwell, ), respectively.…”

Section: List Of Primers Used For Rt‐qpcr Analysiscontrasting

confidence: 62%

Hydrogen peroxide treatment modulates the transcription of sex‐related genes in the sea lice Caligus rogercresseyi

Farlora

Valdebenito-Aguayo

Valenzuela-Muñoz

et al. 2017

Journal of Fish Diseases

View full text Add to dashboard Cite

“…Cholesterol plays an essential role in maintaining the structure of cell membranes; however, excessive cholesterol accumulation in cells induces cytotoxicity ( Tabas, 2002 ). The cholesterol homeostasis within the cell is regulated by endogenous synthesis mainly by a rate-limiting enzyme HMGCR ( Eisa-Beygi et al, 2014 ), receptor-mediated endocytosis by LDL-R on the cell surface and the efflux of cholesterol ( Tabas, 2002 ). During the efflux process of excessive cholesterol, ABCA1 initiates HDL formation ( Tang and Oram, 2009 ) as the primary gatekeeper in cellular cholesterol removal ( Oram and Lawn, 2001 ; Oram and Vaughan, 2006 ; Tang and Oram, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction

Liang

Zhang

et al. 2017

Front. Pharmacol.

View full text Add to dashboard Cite

The strong relationship between cigarette smoking and cardiovascular disease (CVD) has been well-documented, but the mechanisms by which smoking increases CVD risk appear to be multifactorial and incompletely understood. Mesenchymal stem cells (MSCs) are regarded as an important candidate for cell-based therapy in CVD. We hypothesized that MSCs derived from induced pluripotent stem cell (iPSC-MSCs) or bone marrow (BM-MSCs) might alleviate cigarette smoke (CS)-induced cardiac injury. This study aimed to investigate the effects of BM-MSCs or iPSC-MSCs on CS-induced changes in serum and cardiac lipid profiles, oxidative stress and inflammation as well as cardiac function in a rat model of passive smoking. Male Sprague-Dawley rats were randomly selected for exposure to either sham air (SA) as control or 4% CS for 1 h per day for 56 days. On day 29 and 43, human adult BM-MSCs, iPSC-MSCs or PBS were administered intravenously to CS-exposed rats. Results from echocardiography, serum and cardiac lipid profiles, cardiac antioxidant capacity, cardiac pro- and anti-inflammatory cytokines and cardiac morphological changes were evaluated at the end of treatment. iPSC-MSC-treated group showed a greater effect in the improvement of CS-induced cardiac dysfunction over BM-MSCs-treated group as shown by increased percentage left ventricular ejection fraction and percentage fractional shortening, in line with the greater reversal of cardiac lipid abnormality. In addition, iPSC-MSCs administration attenuated CS-induced elevation of cardiac pro-inflammatory cytokines as well as restoration of anti-inflammatory cytokines and anti-oxidative markers, leading to ameliorate cardiac morphological abnormalities. These data suggest that iPSC-MSCs on one hand may restore CS-induced cardiac lipid abnormality and on the other hand may attenuate cardiac oxidative stress and inflammation via inhibition of CS-induced NF-κB activation, leading to improvement of cardiac remodeling and dysfunction. Thus, iPSC-MSCs may be a promising candidate in cell-based therapy to prevent cardiac complications in smokers.

show abstract

Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies

Cited by 18 publications

References 88 publications

The mevalonate pathway is a critical regulator of tendon cell specification

The mevalonate pathway is a critical regulator of tendon cell specification

Hydrogen peroxide treatment modulates the transcription of sex‐related genes in the sea lice Caligus rogercresseyi

Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction

Contact Info

Product

Resources

About